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Article: Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration

TitleDietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration
Authors
Issue Date2001
PublisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org
Citation
Journal Of Pharmacology And Experimental Therapeutics, 2001, v. 299 n. 2, p. 638-644 How to Cite?
AbstractWe investigated the potential of dietary saturated fatty acids to reverse alcoholic liver injury despite continued administration of alcohol. Five groups (six rats/group) of male Wistar rats were studied. Rats in groups 1 and 2 were fed a fish oil-ethanol diet for 8 and 6 weeks, respectively. Rats in groups 3 and 4 were fed fish oil and ethanol for 6 weeks before being switched to isocaloric diets containing ethanol with palm oil (group 3) or medium-chain triglycerides (MCTs, group 4) for 2 weeks. Rats in group 5 were fed fish oil and dextrose for 8 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, nuclear factor-κB (NF-κB) activation, and mRNAs for cyclooxygenase-2 (Cox-2) and tumor necrosis factor-α (TNF-α). Endotoxin in plasma was determined. The most severe inflammation and fibrosis were detected in groups 1 and 2, as were the highest levels of endotoxin, lipid peroxidation, activation of NF-κB, and mRNAs for Cox-2 and TNF-α. After the rats were switched to palm oil or MCT, there was marked histological improvement with decreased levels of endotoxin and lipid peroxidation, absence of NF-κB activation, and reduced expression of TNF-α and Cox-2. A diet enriched in saturated fatty acids effectively reverses alcohol-induced necrosis, inflammation, and fibrosis despite continued alcohol consumption. The therapeutic effects of saturated fatty acids may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased activation of NF-κB and reduced levels of TNF-α and Cox-2.
Persistent Identifierhttp://hdl.handle.net/10722/67361
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.847
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNanji, AAen_HK
dc.contributor.authorJokelainen, Ken_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorRahemtulla, Aen_HK
dc.contributor.authorDannenberg, AJen_HK
dc.date.accessioned2010-09-06T05:54:26Z-
dc.date.available2010-09-06T05:54:26Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics, 2001, v. 299 n. 2, p. 638-644en_HK
dc.identifier.issn0022-3565en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67361-
dc.description.abstractWe investigated the potential of dietary saturated fatty acids to reverse alcoholic liver injury despite continued administration of alcohol. Five groups (six rats/group) of male Wistar rats were studied. Rats in groups 1 and 2 were fed a fish oil-ethanol diet for 8 and 6 weeks, respectively. Rats in groups 3 and 4 were fed fish oil and ethanol for 6 weeks before being switched to isocaloric diets containing ethanol with palm oil (group 3) or medium-chain triglycerides (MCTs, group 4) for 2 weeks. Rats in group 5 were fed fish oil and dextrose for 8 weeks. Liver samples were analyzed for histopathology, lipid peroxidation, nuclear factor-κB (NF-κB) activation, and mRNAs for cyclooxygenase-2 (Cox-2) and tumor necrosis factor-α (TNF-α). Endotoxin in plasma was determined. The most severe inflammation and fibrosis were detected in groups 1 and 2, as were the highest levels of endotoxin, lipid peroxidation, activation of NF-κB, and mRNAs for Cox-2 and TNF-α. After the rats were switched to palm oil or MCT, there was marked histological improvement with decreased levels of endotoxin and lipid peroxidation, absence of NF-κB activation, and reduced expression of TNF-α and Cox-2. A diet enriched in saturated fatty acids effectively reverses alcohol-induced necrosis, inflammation, and fibrosis despite continued alcohol consumption. The therapeutic effects of saturated fatty acids may be explained, at least in part, by reduced endotoxemia and lipid peroxidation, which in turn result in decreased activation of NF-κB and reduced levels of TNF-α and Cox-2.en_HK
dc.languageengen_HK
dc.publisherAmerican Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.orgen_HK
dc.relation.ispartofJournal of Pharmacology and Experimental Therapeuticsen_HK
dc.subject.meshAniline Hydroxylase - metabolismen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCentral Nervous System Depressants - blood - pharmacologyen_HK
dc.subject.meshCyclooxygenase 2en_HK
dc.subject.meshDieten_HK
dc.subject.meshDrug-Induced Liver Injury - diet therapy - pathologyen_HK
dc.subject.meshEndotoxins - blooden_HK
dc.subject.meshEthanol - blood - pharmacologyen_HK
dc.subject.meshFatty Acids - pharmacologyen_HK
dc.subject.meshI-kappa B Proteins - metabolismen_HK
dc.subject.meshIsoenzymes - biosynthesisen_HK
dc.subject.meshLipid Peroxidation - drug effectsen_HK
dc.subject.meshLiver - pathologyen_HK
dc.subject.meshLiver Cirrhosis, Alcoholic - diet therapy - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNF-kappa B - metabolismen_HK
dc.subject.meshNonheme Iron Proteins - metabolismen_HK
dc.subject.meshProstaglandin-Endoperoxide Synthases - biosynthesisen_HK
dc.subject.meshRNA, Messenger - biosynthesisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Wistaren_HK
dc.subject.meshThiobarbituric Acid Reactive Substances - metabolismen_HK
dc.subject.meshTumor Necrosis Factor-alpha - biosynthesisen_HK
dc.titleDietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administrationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3565&volume=299&issue=2&spage=638&epage=644&date=2001&atitle=Dietary+saturated+fatty+acids+reverse+inflammatory+and+fibrotic+changes+in+rat+liver+despite+continued+ethanol+administrationen_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid11602676-
dc.identifier.scopuseid_2-s2.0-0034757922en_HK
dc.identifier.hkuros67757en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034757922&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume299en_HK
dc.identifier.issue2en_HK
dc.identifier.spage638en_HK
dc.identifier.epage644en_HK
dc.identifier.isiWOS:000171764100029-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNanji, AA=35885060300en_HK
dc.identifier.scopusauthoridJokelainen, K=6603792075en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridRahemtulla, A=7003799325en_HK
dc.identifier.scopusauthoridDannenberg, AJ=7102256248en_HK

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