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Article: Screening for ovarian cancer: The preliminary experience of a familial ovarian cancer center

TitleScreening for ovarian cancer: The preliminary experience of a familial ovarian cancer center
Authors
Issue Date1993
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 1993, v. 51 n. 1, p. 12-20 How to Cite?
AbstractWomen with a family history of ovarian cancer represent a high-risk group for the development of epithelial ovarian cancer. From July 1990 through December 1992, 386 women with a first-degree or multiple second-degree relatives with confirmed ovarian cancer were enrolled in a study to assess the utility of screening with transvaginal sonography, color flow doppler, and CA125. The mean age of the group was 41; 85% were premenopausal and 89/384 (23%) had 2 or more relatives with ovarian cancer. An initial ultrasound examination was abnormal in 89/384 (23%), 89% of whom were premenopausal. A persistent ovarian mass was detected in 15 patients and all were surgically proven to be benign. Mean CA125 levels were significantly higher and more variable in pre- vs postmenopausal women. CA125 was ≥35 U/ml in 42/386 (11%) (36-232 U/ml). All but one of these women were premenopausal and 50% subsequently normalized. Two patients who were surgically explored for a rising CA125 had normal ovaries. An additional 19 patients have undergone prophylactic oophorectomy with no consistent histopathologic abnormality identified. These data demonstrate the difficulty inherent in screening a predominantly premenopausal population and do not clearly establish the efficacy of these modalities in the early detection of ovarian cancer.
Persistent Identifierhttp://hdl.handle.net/10722/67360
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMuto, MGen_HK
dc.contributor.authorCramer, DWen_HK
dc.contributor.authorBrown, DLen_HK
dc.contributor.authorWelch, WRen_HK
dc.contributor.authorHarlow, BLen_HK
dc.contributor.authorXu, Hen_HK
dc.contributor.authorBrucks, JPen_HK
dc.contributor.authorTsao, SWen_HK
dc.contributor.authorBerkowitz, RSen_HK
dc.date.accessioned2010-09-06T05:54:26Z-
dc.date.available2010-09-06T05:54:26Z-
dc.date.issued1993en_HK
dc.identifier.citationGynecologic Oncology, 1993, v. 51 n. 1, p. 12-20en_HK
dc.identifier.issn0090-8258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67360-
dc.description.abstractWomen with a family history of ovarian cancer represent a high-risk group for the development of epithelial ovarian cancer. From July 1990 through December 1992, 386 women with a first-degree or multiple second-degree relatives with confirmed ovarian cancer were enrolled in a study to assess the utility of screening with transvaginal sonography, color flow doppler, and CA125. The mean age of the group was 41; 85% were premenopausal and 89/384 (23%) had 2 or more relatives with ovarian cancer. An initial ultrasound examination was abnormal in 89/384 (23%), 89% of whom were premenopausal. A persistent ovarian mass was detected in 15 patients and all were surgically proven to be benign. Mean CA125 levels were significantly higher and more variable in pre- vs postmenopausal women. CA125 was ≥35 U/ml in 42/386 (11%) (36-232 U/ml). All but one of these women were premenopausal and 50% subsequently normalized. Two patients who were surgically explored for a rising CA125 had normal ovaries. An additional 19 patients have undergone prophylactic oophorectomy with no consistent histopathologic abnormality identified. These data demonstrate the difficulty inherent in screening a predominantly premenopausal population and do not clearly establish the efficacy of these modalities in the early detection of ovarian cancer.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_HK
dc.relation.ispartofGynecologic Oncologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntigens, Tumor-Associated, Carbohydrate - blooden_HK
dc.subject.meshCarcinoma in Situ - diagnosis - genetics - prevention & controlen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMass Screening - economics - methodsen_HK
dc.subject.meshMenstrual Cycle - immunologyen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOvarian Neoplasms - diagnosis - genetics - prevention & controlen_HK
dc.subject.meshPredictive Value of Testsen_HK
dc.subject.meshUltrasonography - methodsen_HK
dc.subject.meshVaginaen_HK
dc.titleScreening for ovarian cancer: The preliminary experience of a familial ovarian cancer centeren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0090-8258&volume=51&spage=12&epage=20&date=1993&atitle=Screening+for+ovarian+cancer:+the+preliminary+experience+of+a+familial+ovarian+cancer+centeren_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1006/gyno.1993.1239en_HK
dc.identifier.pmid8244166-
dc.identifier.scopuseid_2-s2.0-0027507573en_HK
dc.identifier.hkuros7740en_HK
dc.identifier.volume51en_HK
dc.identifier.issue1en_HK
dc.identifier.spage12en_HK
dc.identifier.epage20en_HK
dc.identifier.isiWOS:A1993MH94200004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridMuto, MG=7102795179en_HK
dc.identifier.scopusauthoridCramer, DW=7202751360en_HK
dc.identifier.scopusauthoridBrown, DL=36040677100en_HK
dc.identifier.scopusauthoridWelch, WR=35265514400en_HK
dc.identifier.scopusauthoridHarlow, BL=7006382071en_HK
dc.identifier.scopusauthoridXu, H=7407450579en_HK
dc.identifier.scopusauthoridBrucks, JP=7801469848en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK
dc.identifier.scopusauthoridBerkowitz, RS=7201352221en_HK

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