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Article: Survival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion

TitleSurvival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsion
Authors
Issue Date2000
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.com
Citation
Neuroreport, 2000, v. 11 n. 6, p. 1249-1252 How to Cite?
AbstractThe present study examines whether reimplantation of the ventral root could prevent motoneuron death after root avulsion. In the control animals about 65% or 39% of motoneurons survived at 3 or 6 weeks post-injury respectively. More than 60% of them expressed nitric oxide synthase (NOS). In contrast, in animals with ventral root reimplantation, nearly 90% or 80% of motoneurons survived at 3 or 6 weeks post-injury respectively. Expression of NOS due to root avulsion was significantly inhibited in these experimental animals. More interestingly, about 80% of the surviving motoneurons were found to regenerate their axons into the reimplanted ventral root, and all of these regenerating motoneurons were NOS negative. Results of the present study show that reimplantation of avulsed ventral root can greatly enhance motoneuron survival and the surviving motoneurons can regrow their axons into the original ventral root. (C) 2000 Lippincott Williams and Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/67357
ISSN
2015 Impact Factor: 1.343
2015 SCImago Journal Rankings: 0.783
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChai, Hen_HK
dc.contributor.authorWu, Wen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorYip, HKen_HK
dc.date.accessioned2010-09-06T05:54:24Z-
dc.date.available2010-09-06T05:54:24Z-
dc.date.issued2000en_HK
dc.identifier.citationNeuroreport, 2000, v. 11 n. 6, p. 1249-1252en_HK
dc.identifier.issn0959-4965en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67357-
dc.description.abstractThe present study examines whether reimplantation of the ventral root could prevent motoneuron death after root avulsion. In the control animals about 65% or 39% of motoneurons survived at 3 or 6 weeks post-injury respectively. More than 60% of them expressed nitric oxide synthase (NOS). In contrast, in animals with ventral root reimplantation, nearly 90% or 80% of motoneurons survived at 3 or 6 weeks post-injury respectively. Expression of NOS due to root avulsion was significantly inhibited in these experimental animals. More interestingly, about 80% of the surviving motoneurons were found to regenerate their axons into the reimplanted ventral root, and all of these regenerating motoneurons were NOS negative. Results of the present study show that reimplantation of avulsed ventral root can greatly enhance motoneuron survival and the surviving motoneurons can regrow their axons into the original ventral root. (C) 2000 Lippincott Williams and Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neuroreport.comen_HK
dc.relation.ispartofNeuroReporten_HK
dc.rightsNeuroReport. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - enzymologyen_HK
dc.subject.meshCell Nucleus - pathology - ultrastructureen_HK
dc.subject.meshCell Survival - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMicrosurgery - methodsen_HK
dc.subject.meshMotor Neurons - cytology - enzymology - pathologyen_HK
dc.subject.meshNerve Regeneration - physiologyen_HK
dc.subject.meshNitric Oxide Synthase - biosynthesisen_HK
dc.subject.meshNitric Oxide Synthase Type Ien_HK
dc.subject.meshRadiculopathy - surgeryen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshReplantationen_HK
dc.subject.meshSpinal Nerve Roots - cytology - enzymology - physiology - surgeryen_HK
dc.titleSurvival and regeneration of motoneurons in adult rats by reimplantation of ventral root following spinal root avulsionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0959-4965&volume=11&spage=1249&epage=1252&date=2000&atitle=Survival+and+regeneration+of+motoneurons+in+adult+rats+by+reimplantation+of+ventral+root+following+spinal+root+avulsionen_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailYip, HK:hkfyip@hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityYip, HK=rp00285en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10817601-
dc.identifier.scopuseid_2-s2.0-0034720258en_HK
dc.identifier.hkuros51527en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034720258&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1249en_HK
dc.identifier.epage1252en_HK
dc.identifier.isiWOS:000086931600022-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChai, H=35918658800en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridYip, HK=7101980864en_HK

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