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Article: Sprouting of axon-like processes from axotomized retinal ganglion cells is influenced by the distance of axotomy from the cell body and the mode of transplantation of the peripheral nerve

TitleSprouting of axon-like processes from axotomized retinal ganglion cells is influenced by the distance of axotomy from the cell body and the mode of transplantation of the peripheral nerve
Authors
KeywordsAxon-like process
Axotomy
Intravitreal graft
Peripheral nerve graft
Retinal ganglion cell
Issue Date1993
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/09226028.php
Citation
Restorative Neurology And Neuroscience, 1993, v. 6 n. 1, p. 29-34 How to Cite?
AbstractIt is a well known fact that the proximity of an axonal lesion from the cell body influences the degree of neuronal survival; a lesion close to the cell body leads to more severe cell death and vice versa. On the other hand, experiments involving transplantation of a peripheral nerve (PN) to various central nervous system (CNS) regions to induce axonal regeneration have suggested that axonal regrowth is more vigorous when the grafting is performed closer to the cell body. It is not clear, however, whether it is the distance of the site of axotomy or the location of the trophic source (PN graft) or both from the cell body which dictates the vigorousness of axonal regrowth. Using either a model of transplantation of a PN to the retina or implantation of a short PN into the vitreous body of the eye of the adult hamster, we have demonstrated that sprouting of axon-like processes from retinal ganglion cells (RGCs) depends on the distance of axotomy from the cell body when the PN graft is maintained at a constant distance from the cell body. Moreover, it was found that the distance of axotomy at which sprouting of axon-like processes could be induced was different for the 2 paradigms: with the intravitreal PN model, sprouting was observed even after intracranial ON cut whereas it was absent in the PN grafting-to-retina paradigm. This suggests that extrinsic influence (in this case an intravitreal PN) can overcome to a certain extent the growth-suppressive effects due to a certain extent the growth-suppressive effects due to a long distance of axotomy.
Persistent Identifierhttp://hdl.handle.net/10722/67350
ISSN
2015 Impact Factor: 2.661
2015 SCImago Journal Rankings: 1.181

 

DC FieldValueLanguage
dc.contributor.authorCho, EYPen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2010-09-06T05:54:20Z-
dc.date.available2010-09-06T05:54:20Z-
dc.date.issued1993en_HK
dc.identifier.citationRestorative Neurology And Neuroscience, 1993, v. 6 n. 1, p. 29-34en_HK
dc.identifier.issn0922-6028en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67350-
dc.description.abstractIt is a well known fact that the proximity of an axonal lesion from the cell body influences the degree of neuronal survival; a lesion close to the cell body leads to more severe cell death and vice versa. On the other hand, experiments involving transplantation of a peripheral nerve (PN) to various central nervous system (CNS) regions to induce axonal regeneration have suggested that axonal regrowth is more vigorous when the grafting is performed closer to the cell body. It is not clear, however, whether it is the distance of the site of axotomy or the location of the trophic source (PN graft) or both from the cell body which dictates the vigorousness of axonal regrowth. Using either a model of transplantation of a PN to the retina or implantation of a short PN into the vitreous body of the eye of the adult hamster, we have demonstrated that sprouting of axon-like processes from retinal ganglion cells (RGCs) depends on the distance of axotomy from the cell body when the PN graft is maintained at a constant distance from the cell body. Moreover, it was found that the distance of axotomy at which sprouting of axon-like processes could be induced was different for the 2 paradigms: with the intravitreal PN model, sprouting was observed even after intracranial ON cut whereas it was absent in the PN grafting-to-retina paradigm. This suggests that extrinsic influence (in this case an intravitreal PN) can overcome to a certain extent the growth-suppressive effects due to a certain extent the growth-suppressive effects due to a long distance of axotomy.en_HK
dc.languageengen_HK
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/09226028.phpen_HK
dc.relation.ispartofRestorative Neurology and Neuroscienceen_HK
dc.rightsRestorative Neurology and Neuroscience. Copyright © IOS Press.en_HK
dc.subjectAxon-like processen_HK
dc.subjectAxotomyen_HK
dc.subjectIntravitreal graften_HK
dc.subjectPeripheral nerve graften_HK
dc.subjectRetinal ganglion cellen_HK
dc.titleSprouting of axon-like processes from axotomized retinal ganglion cells is influenced by the distance of axotomy from the cell body and the mode of transplantation of the peripheral nerveen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0922-6028&volume=6&spage=29&epage=34&date=1993&atitle=Sprouting+of+axon-like+processes+from+axotomized+retinal+ganglion+cells+is+influenced+by+the+distance+of+axotomy+from+the+cell+body+and+the+mode+of+transplantation+of+the+peripheral+nerveen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3233/RNN-1993-6103-
dc.identifier.pmid21551728-
dc.identifier.scopuseid_2-s2.0-0027772131en_HK
dc.identifier.hkuros7724en_HK
dc.identifier.volume6en_HK
dc.identifier.issue1en_HK
dc.identifier.spage29en_HK
dc.identifier.epage34en_HK
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridCho, EYP=7202649985en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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