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Article: The effects of remaining axons on motoneuron survival and NOS expression following axotomy in the adult rat

TitleThe effects of remaining axons on motoneuron survival and NOS expression following axotomy in the adult rat
Authors
Issue Date1997
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/DNE
Citation
Developmental Neuroscience, 1997, v. 19 n. 3, p. 255-259 How to Cite?
AbstractIt is well known that target removal or distal axotomy in adult animals results in no detectable loss of motoneurons in the spinal cord. By performing axotomy in the seventh cervical (C7) spinal nerve at different distances from the spinal cord (0, 2, 4, 8 mm respectively), this study examines the effects of the remaining axons on motoneuron survival as well as NOS expression. Results of the present study show that axotomy in adult peripheral nerve can induce significant spinal motoneuron death if axotomy is performed close enough to the spinal cord. The closer the axotomy to the spinal cord, the higher the rate of motoneuron loss was observed. The most significant motoneuron loss was found in animals with axotomy at 0 mm to the cord, which was coincident with the highest percent of NOS-positive motoneurons. The rate of survival of motoneurons increases and the percent of NOS-positive motoneurons decreases when the distance of the axotomy to the cord increases from 0 to 4 mm. No significant motoneuron loss nor NOS-positive motoneurons were observed when axotomy was performed at 4 mm and distally. These results indicate that the survival of spinal motoneurons in adult rat following axotomy is largely dependent on the length of the remaining axons. The longer the remaining axon, the better for motoneuron survival. The minimal length of axon for motoneuron survival in adult rat seems to be at least 4 mm.
Persistent Identifierhttp://hdl.handle.net/10722/67349
ISSN
2015 Impact Factor: 2.898
2015 SCImago Journal Rankings: 1.484
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGu, Yen_HK
dc.contributor.authorSpasic, Zen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2010-09-06T05:54:20Z-
dc.date.available2010-09-06T05:54:20Z-
dc.date.issued1997en_HK
dc.identifier.citationDevelopmental Neuroscience, 1997, v. 19 n. 3, p. 255-259en_HK
dc.identifier.issn0378-5866en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67349-
dc.description.abstractIt is well known that target removal or distal axotomy in adult animals results in no detectable loss of motoneurons in the spinal cord. By performing axotomy in the seventh cervical (C7) spinal nerve at different distances from the spinal cord (0, 2, 4, 8 mm respectively), this study examines the effects of the remaining axons on motoneuron survival as well as NOS expression. Results of the present study show that axotomy in adult peripheral nerve can induce significant spinal motoneuron death if axotomy is performed close enough to the spinal cord. The closer the axotomy to the spinal cord, the higher the rate of motoneuron loss was observed. The most significant motoneuron loss was found in animals with axotomy at 0 mm to the cord, which was coincident with the highest percent of NOS-positive motoneurons. The rate of survival of motoneurons increases and the percent of NOS-positive motoneurons decreases when the distance of the axotomy to the cord increases from 0 to 4 mm. No significant motoneuron loss nor NOS-positive motoneurons were observed when axotomy was performed at 4 mm and distally. These results indicate that the survival of spinal motoneurons in adult rat following axotomy is largely dependent on the length of the remaining axons. The longer the remaining axon, the better for motoneuron survival. The minimal length of axon for motoneuron survival in adult rat seems to be at least 4 mm.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/DNEen_HK
dc.relation.ispartofDevelopmental Neuroscienceen_HK
dc.rightsDevelopmental Neuroscience. Copyright © S Karger AG.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAxons - physiologyen_HK
dc.subject.meshBrachial Plexus - injuries - physiologyen_HK
dc.subject.meshCell Survivalen_HK
dc.subject.meshDenervationen_HK
dc.subject.meshEnzyme Inductionen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMotor Neurons - enzymology - pathologyen_HK
dc.subject.meshNerve Regenerationen_HK
dc.subject.meshNerve Tissue Proteins - biosynthesis - geneticsen_HK
dc.subject.meshNitric Oxide Synthase - biosynthesis - geneticsen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSpinal Cord - pathologyen_HK
dc.subject.meshSpinal Nerve Roots - injuriesen_HK
dc.titleThe effects of remaining axons on motoneuron survival and NOS expression following axotomy in the adult raten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-5866&volume=19&spage=255&epage=259&date=1997&atitle=The+effects+of+remaining+axons+on+motoneuron+survival+and+NOS+expression+following+axotomy+in+the+adult+raten_HK
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9208209-
dc.identifier.scopuseid_2-s2.0-0030913939en_HK
dc.identifier.hkuros36689en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030913939&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue3en_HK
dc.identifier.spage255en_HK
dc.identifier.epage259en_HK
dc.identifier.isiWOS:A1997XE46100005-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridGu, Y=55226737100en_HK
dc.identifier.scopusauthoridSpasic, Z=6507149264en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK

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