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Article: Clinical value of ciliary assessment in bronchiectasis
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TitleClinical value of ciliary assessment in bronchiectasis
 
AuthorsTsang, KW1
Tipoe, G1
Sun, J1
Tan, KC1
Leung, R1
Yan, C1
Ko, C1
Ooi, GC1
Ho, JC1
Lam, WK1
 
KeywordsBronchiectasis
cilia
Microtubular defects
Pathogenesis
Transmission electronic microscopy
 
Issue Date2005
 
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
 
CitationLung, 2005, v. 183 n. 2, p. 73-86 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00408-004-2520-5
 
AbstractAlthough ciliary dysfunction and numerous ultrastructural defects have been described, and these could be etiologically important in the development of bronchiectasis, their correlation with relevant clinical parameters have not been systematically evaluated. We have prospectively evaluated the prevalence and clinical significance of ciliary beat frequency and ultrastructural defects of nasal respiratory mucosa obtained from 152 stable patients with idiopathic bronchiectasis (100F, 57.7±15.2 yrs) and 127 control subjects (58F, 56.0±24.2 yrs). Bronchiectasis patients had significantly slower ciliary beat frequency (p < 0.05), and a greater percent of patients had central and peripheral microtubular defects (OR 14.4, 95% CI 5.6-36.8), namely, extra peripheral microtubules, "9+1", "8+2", and compound cilia (p < 0.05), but not microtubular disarrangement, extra matrix or ciliary tail abnormalities (p > 0.05), than controls. Bronchiectasis patients also had a greater proportion of cilia with any ultrastructural microtubular defects, compound cilia, and ciliary tails than controls (p < 0.05). Ciliary beat frequency did not correlate with clinically relevant parameters (p > 0.05). However, the percent of cilia with central, but not peripheral, microtubular defects correlated with 24 h sputum volume (r = 0.40, p = 0.001, and r = -0.04, p = 0.70, respectively) and FEV1 (r = -0.24, p = 0.01, and r = 0.00, p =0.99 respectively). Our results strongly suggest a pathogenic role for central microtubular defects in the development of idiopathic bronchiectasis. © Springer Science+Business Media, Inc. 2005.
 
ISSN0341-2040
2012 Impact Factor: 2.062
2012 SCImago Journal Rankings: 0.867
 
DOIhttp://dx.doi.org/10.1007/s00408-004-2520-5
 
ISI Accession Number IDWOS:000228726900001
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTsang, KW
 
dc.contributor.authorTipoe, G
 
dc.contributor.authorSun, J
 
dc.contributor.authorTan, KC
 
dc.contributor.authorLeung, R
 
dc.contributor.authorYan, C
 
dc.contributor.authorKo, C
 
dc.contributor.authorOoi, GC
 
dc.contributor.authorHo, JC
 
dc.contributor.authorLam, WK
 
dc.date.accessioned2010-09-06T05:54:17Z
 
dc.date.available2010-09-06T05:54:17Z
 
dc.date.issued2005
 
dc.description.abstractAlthough ciliary dysfunction and numerous ultrastructural defects have been described, and these could be etiologically important in the development of bronchiectasis, their correlation with relevant clinical parameters have not been systematically evaluated. We have prospectively evaluated the prevalence and clinical significance of ciliary beat frequency and ultrastructural defects of nasal respiratory mucosa obtained from 152 stable patients with idiopathic bronchiectasis (100F, 57.7±15.2 yrs) and 127 control subjects (58F, 56.0±24.2 yrs). Bronchiectasis patients had significantly slower ciliary beat frequency (p < 0.05), and a greater percent of patients had central and peripheral microtubular defects (OR 14.4, 95% CI 5.6-36.8), namely, extra peripheral microtubules, "9+1", "8+2", and compound cilia (p < 0.05), but not microtubular disarrangement, extra matrix or ciliary tail abnormalities (p > 0.05), than controls. Bronchiectasis patients also had a greater proportion of cilia with any ultrastructural microtubular defects, compound cilia, and ciliary tails than controls (p < 0.05). Ciliary beat frequency did not correlate with clinically relevant parameters (p > 0.05). However, the percent of cilia with central, but not peripheral, microtubular defects correlated with 24 h sputum volume (r = 0.40, p = 0.001, and r = -0.04, p = 0.70, respectively) and FEV1 (r = -0.24, p = 0.01, and r = 0.00, p =0.99 respectively). Our results strongly suggest a pathogenic role for central microtubular defects in the development of idiopathic bronchiectasis. © Springer Science+Business Media, Inc. 2005.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationLung, 2005, v. 183 n. 2, p. 73-86 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00408-004-2520-5
 
dc.identifier.doihttp://dx.doi.org/10.1007/s00408-004-2520-5
 
dc.identifier.epage86
 
dc.identifier.hkuros98982
 
dc.identifier.isiWOS:000228726900001
 
dc.identifier.issn0341-2040
2012 Impact Factor: 2.062
2012 SCImago Journal Rankings: 0.867
 
dc.identifier.issue2
 
dc.identifier.openurl
 
dc.identifier.pmid16026012
 
dc.identifier.scopuseid_2-s2.0-23344454722
 
dc.identifier.spage73
 
dc.identifier.urihttp://hdl.handle.net/10722/67344
 
dc.identifier.volume183
 
dc.languageeng
 
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofLung
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 and over
 
dc.subject.meshBronchiectasis - pathology
 
dc.subject.meshCilia - physiology - ultrastructure
 
dc.subject.meshHumans
 
dc.subject.meshMicroscopy, Electron, Transmission
 
dc.subject.meshMicrotubules
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNasal Mucosa - cytology - ultrastructure
 
dc.subject.meshProspective Studies
 
dc.subject.meshSpirometry
 
dc.subjectBronchiectasis
 
dc.subjectcilia
 
dc.subjectMicrotubular defects
 
dc.subjectPathogenesis
 
dc.subjectTransmission electronic microscopy
 
dc.titleClinical value of ciliary assessment in bronchiectasis
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong