Article: Clinical value of ciliary assessment in bronchiectasis

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleClinical value of ciliary assessment in bronchiectasis
AuthorsTsang, KW1
Tipoe, G1
Sun, J1
Tan, KC1
Leung, R1
Yan, C1
Ko, C1
Ooi, GC1
Ho, JC1
Lam, WK1
KeywordsBronchiectasis
cilia
Microtubular defects
Pathogenesis
Transmission electronic microscopy
Issue Date2005
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
CitationLung, 2005, v. 183 n. 2, p. 73-86 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00408-004-2520-5
AbstractAlthough ciliary dysfunction and numerous ultrastructural defects have been described, and these could be etiologically important in the development of bronchiectasis, their correlation with relevant clinical parameters have not been systematically evaluated. We have prospectively evaluated the prevalence and clinical significance of ciliary beat frequency and ultrastructural defects of nasal respiratory mucosa obtained from 152 stable patients with idiopathic bronchiectasis (100F, 57.7±15.2 yrs) and 127 control subjects (58F, 56.0±24.2 yrs). Bronchiectasis patients had significantly slower ciliary beat frequency (p < 0.05), and a greater percent of patients had central and peripheral microtubular defects (OR 14.4, 95% CI 5.6-36.8), namely, extra peripheral microtubules, "9+1", "8+2", and compound cilia (p < 0.05), but not microtubular disarrangement, extra matrix or ciliary tail abnormalities (p > 0.05), than controls. Bronchiectasis patients also had a greater proportion of cilia with any ultrastructural microtubular defects, compound cilia, and ciliary tails than controls (p < 0.05). Ciliary beat frequency did not correlate with clinically relevant parameters (p > 0.05). However, the percent of cilia with central, but not peripheral, microtubular defects correlated with 24 h sputum volume (r = 0.40, p = 0.001, and r = -0.04, p = 0.70, respectively) and FEV1 (r = -0.24, p = 0.01, and r = 0.00, p =0.99 respectively). Our results strongly suggest a pathogenic role for central microtubular defects in the development of idiopathic bronchiectasis. © Springer Science+Business Media, Inc. 2005.
ISSN0341-2040
2011 Impact Factor: 1.899
2011 SCImago Journal Rankings: 0.168
DOIhttp://dx.doi.org/10.1007/s00408-004-2520-5
ISI Accession Number IDWOS:000228726900001
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTsang, KW
dc.contributor.authorTipoe, G
dc.contributor.authorSun, J
dc.contributor.authorTan, KC
dc.contributor.authorLeung, R
dc.contributor.authorYan, C
dc.contributor.authorKo, C
dc.contributor.authorOoi, GC
dc.contributor.authorHo, JC
dc.contributor.authorLam, WK
dc.date.accessioned2010-09-06T05:54:17Z
dc.date.available2010-09-06T05:54:17Z
dc.date.issued2005
dc.description.abstractAlthough ciliary dysfunction and numerous ultrastructural defects have been described, and these could be etiologically important in the development of bronchiectasis, their correlation with relevant clinical parameters have not been systematically evaluated. We have prospectively evaluated the prevalence and clinical significance of ciliary beat frequency and ultrastructural defects of nasal respiratory mucosa obtained from 152 stable patients with idiopathic bronchiectasis (100F, 57.7±15.2 yrs) and 127 control subjects (58F, 56.0±24.2 yrs). Bronchiectasis patients had significantly slower ciliary beat frequency (p < 0.05), and a greater percent of patients had central and peripheral microtubular defects (OR 14.4, 95% CI 5.6-36.8), namely, extra peripheral microtubules, "9+1", "8+2", and compound cilia (p < 0.05), but not microtubular disarrangement, extra matrix or ciliary tail abnormalities (p > 0.05), than controls. Bronchiectasis patients also had a greater proportion of cilia with any ultrastructural microtubular defects, compound cilia, and ciliary tails than controls (p < 0.05). Ciliary beat frequency did not correlate with clinically relevant parameters (p > 0.05). However, the percent of cilia with central, but not peripheral, microtubular defects correlated with 24 h sputum volume (r = 0.40, p = 0.001, and r = -0.04, p = 0.70, respectively) and FEV1 (r = -0.24, p = 0.01, and r = 0.00, p =0.99 respectively). Our results strongly suggest a pathogenic role for central microtubular defects in the development of idiopathic bronchiectasis. © Springer Science+Business Media, Inc. 2005.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLung, 2005, v. 183 n. 2, p. 73-86 [How to Cite?]
DOI: http://dx.doi.org/10.1007/s00408-004-2520-5
dc.identifier.doihttp://dx.doi.org/10.1007/s00408-004-2520-5
dc.identifier.epage86
dc.identifier.hkuros98982
dc.identifier.isiWOS:000228726900001
dc.identifier.issn0341-2040
2011 Impact Factor: 1.899
2011 SCImago Journal Rankings: 0.168
dc.identifier.issue2
dc.identifier.openurl
dc.identifier.pmid16026012
dc.identifier.scopuseid_2-s2.0-23344454722
dc.identifier.spage73
dc.identifier.urihttp://hdl.handle.net/10722/67344
dc.identifier.volume183
dc.languageeng
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
dc.publisher.placeUnited States
dc.relation.ispartofLung
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshBronchiectasis - pathology
dc.subject.meshCilia - physiology - ultrastructure
dc.subject.meshHumans
dc.subject.meshMicroscopy, Electron, Transmission
dc.subject.meshMicrotubules
dc.subject.meshMiddle Aged
dc.subject.meshNasal Mucosa - cytology - ultrastructure
dc.subject.meshProspective Studies
dc.subject.meshSpirometry
dc.subjectBronchiectasis
dc.subjectcilia
dc.subjectMicrotubular defects
dc.subjectPathogenesis
dc.subjectTransmission electronic microscopy
dc.titleClinical value of ciliary assessment in bronchiectasis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong