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Article: Clinical value of ciliary assessment in bronchiectasis

TitleClinical value of ciliary assessment in bronchiectasis
Authors
KeywordsBronchiectasis
cilia
Microtubular defects
Pathogenesis
Transmission electronic microscopy
Issue Date2005
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
Citation
Lung, 2005, v. 183 n. 2, p. 73-86 How to Cite?
AbstractAlthough ciliary dysfunction and numerous ultrastructural defects have been described, and these could be etiologically important in the development of bronchiectasis, their correlation with relevant clinical parameters have not been systematically evaluated. We have prospectively evaluated the prevalence and clinical significance of ciliary beat frequency and ultrastructural defects of nasal respiratory mucosa obtained from 152 stable patients with idiopathic bronchiectasis (100F, 57.7±15.2 yrs) and 127 control subjects (58F, 56.0±24.2 yrs). Bronchiectasis patients had significantly slower ciliary beat frequency (p < 0.05), and a greater percent of patients had central and peripheral microtubular defects (OR 14.4, 95% CI 5.6-36.8), namely, extra peripheral microtubules, "9+1", "8+2", and compound cilia (p < 0.05), but not microtubular disarrangement, extra matrix or ciliary tail abnormalities (p > 0.05), than controls. Bronchiectasis patients also had a greater proportion of cilia with any ultrastructural microtubular defects, compound cilia, and ciliary tails than controls (p < 0.05). Ciliary beat frequency did not correlate with clinically relevant parameters (p > 0.05). However, the percent of cilia with central, but not peripheral, microtubular defects correlated with 24 h sputum volume (r = 0.40, p = 0.001, and r = -0.04, p = 0.70, respectively) and FEV1 (r = -0.24, p = 0.01, and r = 0.00, p =0.99 respectively). Our results strongly suggest a pathogenic role for central microtubular defects in the development of idiopathic bronchiectasis. © Springer Science+Business Media, Inc. 2005.
Persistent Identifierhttp://hdl.handle.net/10722/67344
ISSN
2014 Impact Factor: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, KWen_HK
dc.contributor.authorTipoe, Gen_HK
dc.contributor.authorSun, Jen_HK
dc.contributor.authorTan, KCen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorYan, Cen_HK
dc.contributor.authorKo, Cen_HK
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorHo, JCen_HK
dc.contributor.authorLam, WKen_HK
dc.date.accessioned2010-09-06T05:54:17Z-
dc.date.available2010-09-06T05:54:17Z-
dc.date.issued2005en_HK
dc.identifier.citationLung, 2005, v. 183 n. 2, p. 73-86en_HK
dc.identifier.issn0341-2040en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67344-
dc.description.abstractAlthough ciliary dysfunction and numerous ultrastructural defects have been described, and these could be etiologically important in the development of bronchiectasis, their correlation with relevant clinical parameters have not been systematically evaluated. We have prospectively evaluated the prevalence and clinical significance of ciliary beat frequency and ultrastructural defects of nasal respiratory mucosa obtained from 152 stable patients with idiopathic bronchiectasis (100F, 57.7±15.2 yrs) and 127 control subjects (58F, 56.0±24.2 yrs). Bronchiectasis patients had significantly slower ciliary beat frequency (p < 0.05), and a greater percent of patients had central and peripheral microtubular defects (OR 14.4, 95% CI 5.6-36.8), namely, extra peripheral microtubules, "9+1", "8+2", and compound cilia (p < 0.05), but not microtubular disarrangement, extra matrix or ciliary tail abnormalities (p > 0.05), than controls. Bronchiectasis patients also had a greater proportion of cilia with any ultrastructural microtubular defects, compound cilia, and ciliary tails than controls (p < 0.05). Ciliary beat frequency did not correlate with clinically relevant parameters (p > 0.05). However, the percent of cilia with central, but not peripheral, microtubular defects correlated with 24 h sputum volume (r = 0.40, p = 0.001, and r = -0.04, p = 0.70, respectively) and FEV1 (r = -0.24, p = 0.01, and r = 0.00, p =0.99 respectively). Our results strongly suggest a pathogenic role for central microtubular defects in the development of idiopathic bronchiectasis. © Springer Science+Business Media, Inc. 2005.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/en_HK
dc.relation.ispartofLungen_HK
dc.subjectBronchiectasisen_HK
dc.subjectciliaen_HK
dc.subjectMicrotubular defectsen_HK
dc.subjectPathogenesisen_HK
dc.subjectTransmission electronic microscopyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshBronchiectasis - pathologyen_HK
dc.subject.meshCilia - physiology - ultrastructureen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMicroscopy, Electron, Transmissionen_HK
dc.subject.meshMicrotubulesen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNasal Mucosa - cytology - ultrastructureen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshSpirometryen_HK
dc.titleClinical value of ciliary assessment in bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0341-2040&volume=183&issue=2&spage=73&epage=86&date=2005&atitle=Clinical+value+of+ciliary+assessment+in+bronchiectasisen_HK
dc.identifier.emailTipoe, G:tgeorge@hkucc.hku.hken_HK
dc.identifier.emailTan, KC:kcbtan@hku.hken_HK
dc.identifier.emailHo, JC:jhocm@hku.hken_HK
dc.identifier.authorityTipoe, G=rp00371en_HK
dc.identifier.authorityTan, KC=rp00402en_HK
dc.identifier.authorityHo, JC=rp00258en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00408-004-2520-5en_HK
dc.identifier.pmid16026012en_HK
dc.identifier.scopuseid_2-s2.0-23344454722en_HK
dc.identifier.hkuros98982en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-23344454722&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume183en_HK
dc.identifier.issue2en_HK
dc.identifier.spage73en_HK
dc.identifier.epage86en_HK
dc.identifier.isiWOS:000228726900001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTsang, KW=7201555024en_HK
dc.identifier.scopusauthoridTipoe, G=7003550610en_HK
dc.identifier.scopusauthoridSun, J=7410371598en_HK
dc.identifier.scopusauthoridTan, KC=8082703100en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK
dc.identifier.scopusauthoridYan, C=8728540500en_HK
dc.identifier.scopusauthoridKo, C=8728540600en_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridHo, JC=7402649981en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK

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