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Article: Comparative genomic hybridization: Comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China

TitleComparative genomic hybridization: Comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China
Authors
KeywordsChromosome aberration
Comparative genomic hybridization
Esophageal squamous cell carcinoma
Gastric cardia adenocarcinoma
Issue Date2006
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DES
Citation
Diseases Of The Esophagus, 2006, v. 19 n. 6, p. 459-467 How to Cite?
AbstractEsophageal squamous cell carcinoma (SCC) remains the leading cause of cancer related deaths in Linzhou (formerly Linxian), the highest incidence area for esophageal cancer (EC) in Henan, northern China. In China, gastric cardia adenocarcinoma (GCA) shares very similar geographic distribution with SCC, suggesting the possibility of similar risk factors involved in SCC and GCA carcinogenesis in these areas. However, the underlying genetic alterations for esophageal and gastric cardia carcinogenesis, especially for the molecular difference between SCC and GCA, are largely unknown. The present study was thus undertaken to determine the difference in chromosomal aberrations in SCC (n = 37) and GCA (n = 31) using the comparative genomic hybridization method (CGH). All the patients were from Linzhou, Henan, a high-risk geographic region for both SCC and GCA. CGH results showed that chromosomal aberrations with different degrees were identified both in SCC and GCA. In SCC, chromosomal profile of DNA copy number was characterized by most frequently detected gains at 8q (29/37, 78%), 3q (24/37, 65%) and 5p (19/37, 51%); and frequently detected losses at 3p (21/37, 57%), 8p and 9q (14/37, 38%). In GCA, the frequently detected gains were identified at 20q (13/31, 42%), 6q (12/31, 39%) and 8q (11/31, 35%); the DNA copy number losses in GCA occurred frequently at 17p (17/31, 55%), 19p (15/31, 48%) and 1p (14/31, 45%). Statistically, there were evident differences between SCC and GCA in DNA copy number gains at 8q, 3q, 5p and 20q (P< 0.05) and in losses at 3p, 8p, 5q, 17p and 18q (P < 0.05). Gains at 8q were frequently observed in both SCC and GCA. Gains at 3q and 8p were frequently observed in TNM stage III of both SCC and GCA. The present CGH results provide candidate regions that may contain specific related genes involved in SCC and GCA in the Linzhou population. Gains at 8q, 3q and 5p and losses at 3p, 8p and 9q were specifically implicated in SCC; gains at 20q, 6q and 8q and losses at 17p, 19p and 1p were specifically implicated in GCA; gains at 8q were implicated in both SCC and GCA. © 2006 The Authors Journal compilation © 2006 The International Society for Diseases of the Esophagus.
Persistent Identifierhttp://hdl.handle.net/10722/67337
ISSN
2015 Impact Factor: 2.146
2015 SCImago Journal Rankings: 0.760
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, LDen_HK
dc.contributor.authorQin, YRen_HK
dc.contributor.authorFan, ZMen_HK
dc.contributor.authorKwong, Den_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorTsao, GSWen_HK
dc.contributor.authorSham, Jen_HK
dc.contributor.authorLi, JLen_HK
dc.contributor.authorFeng, XSen_HK
dc.date.accessioned2010-09-06T05:54:12Z-
dc.date.available2010-09-06T05:54:12Z-
dc.date.issued2006en_HK
dc.identifier.citationDiseases Of The Esophagus, 2006, v. 19 n. 6, p. 459-467en_HK
dc.identifier.issn1120-8694en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67337-
dc.description.abstractEsophageal squamous cell carcinoma (SCC) remains the leading cause of cancer related deaths in Linzhou (formerly Linxian), the highest incidence area for esophageal cancer (EC) in Henan, northern China. In China, gastric cardia adenocarcinoma (GCA) shares very similar geographic distribution with SCC, suggesting the possibility of similar risk factors involved in SCC and GCA carcinogenesis in these areas. However, the underlying genetic alterations for esophageal and gastric cardia carcinogenesis, especially for the molecular difference between SCC and GCA, are largely unknown. The present study was thus undertaken to determine the difference in chromosomal aberrations in SCC (n = 37) and GCA (n = 31) using the comparative genomic hybridization method (CGH). All the patients were from Linzhou, Henan, a high-risk geographic region for both SCC and GCA. CGH results showed that chromosomal aberrations with different degrees were identified both in SCC and GCA. In SCC, chromosomal profile of DNA copy number was characterized by most frequently detected gains at 8q (29/37, 78%), 3q (24/37, 65%) and 5p (19/37, 51%); and frequently detected losses at 3p (21/37, 57%), 8p and 9q (14/37, 38%). In GCA, the frequently detected gains were identified at 20q (13/31, 42%), 6q (12/31, 39%) and 8q (11/31, 35%); the DNA copy number losses in GCA occurred frequently at 17p (17/31, 55%), 19p (15/31, 48%) and 1p (14/31, 45%). Statistically, there were evident differences between SCC and GCA in DNA copy number gains at 8q, 3q, 5p and 20q (P< 0.05) and in losses at 3p, 8p, 5q, 17p and 18q (P < 0.05). Gains at 8q were frequently observed in both SCC and GCA. Gains at 3q and 8p were frequently observed in TNM stage III of both SCC and GCA. The present CGH results provide candidate regions that may contain specific related genes involved in SCC and GCA in the Linzhou population. Gains at 8q, 3q and 5p and losses at 3p, 8p and 9q were specifically implicated in SCC; gains at 20q, 6q and 8q and losses at 17p, 19p and 1p were specifically implicated in GCA; gains at 8q were implicated in both SCC and GCA. © 2006 The Authors Journal compilation © 2006 The International Society for Diseases of the Esophagus.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/DESen_HK
dc.relation.ispartofDiseases of the Esophagusen_HK
dc.subjectChromosome aberrationen_HK
dc.subjectComparative genomic hybridizationen_HK
dc.subjectEsophageal squamous cell carcinomaen_HK
dc.subjectGastric cardia adenocarcinomaen_HK
dc.subject.meshAdenocarcinoma - epidemiology - geneticsen_HK
dc.subject.meshCarcinoma, Squamous Cell - epidemiology - genetics - pathologyen_HK
dc.subject.meshCardiaen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshChromosome Aberrationsen_HK
dc.subject.meshEsophageal Neoplasms - epidemiology - genetics - pathologyen_HK
dc.subject.meshGene Dosage - geneticsen_HK
dc.subject.meshGene Expression Profilingen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.titleComparative genomic hybridization: Comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1120-8694&volume=19&spage=459&epage=467&date=2006&atitle=Comparative+genomic+hybridization:+comparison+between+esophageal+squamous+cell+carcinoma+and+gastric+cardia+adenocarcinoma+from+a+high-incidence+area+for+both+cancers+in+Henan,+northern+China.en_HK
dc.identifier.emailKwong, D:dlwkwong@hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.emailTsao, GSW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityKwong, D=rp00414en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityTsao, GSW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1442-2050.2006.00620.xen_HK
dc.identifier.pmid17069589en_HK
dc.identifier.scopuseid_2-s2.0-33750477285en_HK
dc.identifier.hkuros133756en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750477285&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issue6en_HK
dc.identifier.spage459en_HK
dc.identifier.epage467en_HK
dc.identifier.isiWOS:000241563800008-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridWang, LD=12242861000en_HK
dc.identifier.scopusauthoridQin, YR=7403100680en_HK
dc.identifier.scopusauthoridFan, ZM=7402099547en_HK
dc.identifier.scopusauthoridKwong, D=15744231600en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridTsao, GSW=7102813116en_HK
dc.identifier.scopusauthoridSham, J=7101655565en_HK
dc.identifier.scopusauthoridLi, JL=10839988300en_HK
dc.identifier.scopusauthoridFeng, XS=7403046906en_HK
dc.identifier.citeulike914418-

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