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Article: Combined effect of isoflurane and esmolol on sympathetic responses to tracheal intubation

TitleCombined effect of isoflurane and esmolol on sympathetic responses to tracheal intubation
Isoflurane與Esmolol對氣管插管時所引起交感神經反應的效果
Authors
Issue Date2000
PublisherTaiwan Society of Anesthesiologists. The Journal's web site is located at www.anesth.org.tw
Citation
Acta Anaesthesiologica Sinica, 2000, v. 38 n. 3, p. 123-130 How to Cite?
麻醉學雜誌, 2000, v. 38 n. 3, p. 123-130 How to Cite?
AbstractBACKGROUND: Influences of isoflurane and esmolol on endotracheal intubation induced sympathetic changes could be different. The effect of isoflurane and its combination with esmolol on catecholamine, blood pressure and pulse during endotracheal intubation were investigated. METHODS: Thirty patients were anesthetized with 3.0% isoflurane and tracheal intubation was carried out at the 5th min following the exposure to isoflurane. Half of them received intravenous saline and the other half received esmolol 2 mg/kg at the 4th min. Cardiovascular parameters were recorded and venous blood samples were taken for measurement of catecholamines every min. RESULTS: One min after administration of isoflurane, there was increase of heart rate (P < 0.05), while at the same time the epinephrine level fell (P < 0.05) and norepinephrine level remained unaltered. Both catecholamines raised after intubation (P < 0.05). The sympathetic responses to and the beta-antagonistic effect of esmolol on intubation were not significantly changed in the presence of isoflurane. CONCLUSIONS: Isoflurane increased heart rate while paradoxically decreased epinephrine. Norepinephrine was more specifically related to endotracheal intubation, for its serum level had little change before the event. Based on catecholamine findings, the mechanism of isoflurane effect on the sympathetic system is probably different from that of endotracheal intubation.
背景:此實驗測量isoflurane對由氣管插管引起交感神經變化的影響,以及isoflurane與esmolol同時給與時的效果。方法:三十位病人,在用3%isoflurane換氣四分鍾後,注射esmolol或監水,每分鍾測量一次血液兒茶酚胺含量(catecholamine)及血壓與脈搏。結果:在給予isoflurane一分鍾後,脈博升高(P<0.05),在此同時,血液腎上腺素減低(P<0.05),去甲腎上腺素則無變化。插管後兩種激素皆升高。Isoflurane對由插管引起交感神經變化與esmolol之β效果皆無影響。結論:由isoflurane引起心博過快時,腎上腺素反而減低。去甲腎上腺素只在插管後有升高。表示與它有特別關系,因在此前沒有變化。Isoflurane效果與由插管引起的交感神經變化可能不經同一機轉。
Persistent Identifierhttp://hdl.handle.net/10722/67331
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorYang, JCen_HK
dc.contributor.authorSiu, TSen_HK
dc.contributor.authorNg, KFen_HK
dc.contributor.authorGong, Zen_HK
dc.contributor.authorTsui, SLen_HK
dc.contributor.authorWong, JSen_HK
dc.date.accessioned2010-09-06T05:54:02Z-
dc.date.available2010-09-06T05:54:02Z-
dc.date.issued2000en_HK
dc.identifier.citationActa Anaesthesiologica Sinica, 2000, v. 38 n. 3, p. 123-130en_HK
dc.identifier.citation麻醉學雜誌, 2000, v. 38 n. 3, p. 123-130-
dc.identifier.issn0254-1319en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67331-
dc.description.abstractBACKGROUND: Influences of isoflurane and esmolol on endotracheal intubation induced sympathetic changes could be different. The effect of isoflurane and its combination with esmolol on catecholamine, blood pressure and pulse during endotracheal intubation were investigated. METHODS: Thirty patients were anesthetized with 3.0% isoflurane and tracheal intubation was carried out at the 5th min following the exposure to isoflurane. Half of them received intravenous saline and the other half received esmolol 2 mg/kg at the 4th min. Cardiovascular parameters were recorded and venous blood samples were taken for measurement of catecholamines every min. RESULTS: One min after administration of isoflurane, there was increase of heart rate (P < 0.05), while at the same time the epinephrine level fell (P < 0.05) and norepinephrine level remained unaltered. Both catecholamines raised after intubation (P < 0.05). The sympathetic responses to and the beta-antagonistic effect of esmolol on intubation were not significantly changed in the presence of isoflurane. CONCLUSIONS: Isoflurane increased heart rate while paradoxically decreased epinephrine. Norepinephrine was more specifically related to endotracheal intubation, for its serum level had little change before the event. Based on catecholamine findings, the mechanism of isoflurane effect on the sympathetic system is probably different from that of endotracheal intubation.en_HK
dc.description.abstract背景:此實驗測量isoflurane對由氣管插管引起交感神經變化的影響,以及isoflurane與esmolol同時給與時的效果。方法:三十位病人,在用3%isoflurane換氣四分鍾後,注射esmolol或監水,每分鍾測量一次血液兒茶酚胺含量(catecholamine)及血壓與脈搏。結果:在給予isoflurane一分鍾後,脈博升高(P<0.05),在此同時,血液腎上腺素減低(P<0.05),去甲腎上腺素則無變化。插管後兩種激素皆升高。Isoflurane對由插管引起交感神經變化與esmolol之β效果皆無影響。結論:由isoflurane引起心博過快時,腎上腺素反而減低。去甲腎上腺素只在插管後有升高。表示與它有特別關系,因在此前沒有變化。Isoflurane效果與由插管引起的交感神經變化可能不經同一機轉。-
dc.languageengen_HK
dc.publisherTaiwan Society of Anesthesiologists. The Journal's web site is located at www.anesth.org.tw-
dc.relation.ispartofActa Anaesthesiologica Sinicaen_HK
dc.relation.ispartof麻醉學雜誌-
dc.subject.meshAdrenergic beta-Antagonists - pharmacologyen_HK
dc.subject.meshAnesthetics, Inhalation - pharmacologyen_HK
dc.subject.meshIntubation, Intratrachealen_HK
dc.subject.meshIsoflurane - pharmacologyen_HK
dc.subject.meshPropanolamines - pharmacologyen_HK
dc.titleCombined effect of isoflurane and esmolol on sympathetic responses to tracheal intubationen_HK
dc.titleIsoflurane與Esmolol對氣管插管時所引起交感神經反應的效果-
dc.typeArticleen_HK
dc.identifier.emailYang, JC: jcsyang@hkucc.hku.hken_HK
dc.identifier.emailNg, KF: jkfng@hku.hk-
dc.identifier.emailTsui, SL: sltsui@hkucc.hku.hk-
dc.identifier.authorityNg, KF=rp00544en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11125686en_HK
dc.identifier.scopuseid_2-s2.0-0034524117en_HK
dc.identifier.hkuros57127en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034524117&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue3en_HK
dc.identifier.spage123en_HK
dc.identifier.epage130en_HK
dc.publisher.placeTaiwan-

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