File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Coagulation and cytokine profile after major hepatobiliary surgery in Chinese patients

TitleCoagulation and cytokine profile after major hepatobiliary surgery in Chinese patients
Authors
Issue Date2000
PublisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.html
Citation
Hepato-Gastroenterology, 2000, v. 47 n. 34, p. 1067-1071 How to Cite?
AbstractBackground/Aims: Hypercoagulability and increased circulating cytokine levels have been separately reported after surgical operations. We investigated whether the cytokine level and post-operative coagulation profile would change similarly in Chinese patients undergoing major hepatobiliary surgery. Methodology: Serial serum levels of IL-6 IL-1β and TNF-α were measured by colorimetric ELISA. Serial coagulation profile was measured by thrombelastography. Hemoglobin and white cell counts were also measured serially. Results: Only mild hypercoagulability was found at the 12th and 144th hours, evidenced by shortening of r-time and k-time on thrombelastography (P<0.05). IL-6 and IL-1β levels were significantly raised from the 12th hour (P<0.01) while TNF-α level was unchanged. From the 3rd hour to the 48th hour, there was negative correlation between IL-6 levels and various thrombelastographic parameters such as coagulation index (r=-0.777, P<0.001); k-time (r=0.478, P<0.05); maximum amplitude (r=-0.688, P<0.01) and angle (r=-0.665, P<0.01). Conclusions: We observed a much milder degree of hypercoagulability in Chinese patients after major hepatobiliary surgery as compared to those reported in other operations in non-Chinese patients. Unlike in sepsis where a close link between increased cytokine levels and hypercoagulability has been reported, increase in IL-6 was associated with less hypercoagulability in Chinese patients after major hepatobiliary surgery.
Persistent Identifierhttp://hdl.handle.net/10722/67329
ISSN
2015 Impact Factor: 0.792
2015 SCImago Journal Rankings: 0.446
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KFJen_HK
dc.contributor.authorHo, ETFen_HK
dc.contributor.authorGong, Zen_HK
dc.contributor.authorXiong, Yen_HK
dc.date.accessioned2010-09-06T05:54:01Z-
dc.date.available2010-09-06T05:54:01Z-
dc.date.issued2000en_HK
dc.identifier.citationHepato-Gastroenterology, 2000, v. 47 n. 34, p. 1067-1071en_HK
dc.identifier.issn0172-6390en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67329-
dc.description.abstractBackground/Aims: Hypercoagulability and increased circulating cytokine levels have been separately reported after surgical operations. We investigated whether the cytokine level and post-operative coagulation profile would change similarly in Chinese patients undergoing major hepatobiliary surgery. Methodology: Serial serum levels of IL-6 IL-1β and TNF-α were measured by colorimetric ELISA. Serial coagulation profile was measured by thrombelastography. Hemoglobin and white cell counts were also measured serially. Results: Only mild hypercoagulability was found at the 12th and 144th hours, evidenced by shortening of r-time and k-time on thrombelastography (P<0.05). IL-6 and IL-1β levels were significantly raised from the 12th hour (P<0.01) while TNF-α level was unchanged. From the 3rd hour to the 48th hour, there was negative correlation between IL-6 levels and various thrombelastographic parameters such as coagulation index (r=-0.777, P<0.001); k-time (r=0.478, P<0.05); maximum amplitude (r=-0.688, P<0.01) and angle (r=-0.665, P<0.01). Conclusions: We observed a much milder degree of hypercoagulability in Chinese patients after major hepatobiliary surgery as compared to those reported in other operations in non-Chinese patients. Unlike in sepsis where a close link between increased cytokine levels and hypercoagulability has been reported, increase in IL-6 was associated with less hypercoagulability in Chinese patients after major hepatobiliary surgery.en_HK
dc.languageengen_HK
dc.publisherHepato-Gastroenterology. The Journal's web site is located at http://www.thieme.de/hepato/index.htmlen_HK
dc.relation.ispartofHepato-Gastroenterologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBlood Cell Counten_HK
dc.subject.meshCytokines - blooden_HK
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHemoglobins - analysisen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterleukin-1 - blooden_HK
dc.subject.meshInterleukin-6 - blooden_HK
dc.subject.meshLiver Diseases - surgeryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPostoperative Complications - diagnosis - etiologyen_HK
dc.subject.meshThrombelastographyen_HK
dc.subject.meshThrombophilia - diagnosis - ethnology - etiologyen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTumor Necrosis Factor-alpha - analysisen_HK
dc.titleCoagulation and cytokine profile after major hepatobiliary surgery in Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0172-6390&volume=47&spage=1067&epage=1071&date=2000&atitle=Coagulation+and+cytokine+profile+after+major+hepatobiliary+surgery+in+Chinese+Patientsen_HK
dc.identifier.emailNg, KFJ:jkfng@hkucc.hku.hken_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11020881-
dc.identifier.scopuseid_2-s2.0-0033804099en_HK
dc.identifier.hkuros57124en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033804099&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47en_HK
dc.identifier.issue34en_HK
dc.identifier.spage1067en_HK
dc.identifier.epage1071en_HK
dc.identifier.isiWOS:000089484900039-
dc.publisher.placeGreeceen_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats