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Article: A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers

TitleA prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers
Authors
Issue Date2005
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.org
Citation
Anesthesia And Analgesia, 2005, v. 101 n. 2, p. 423-426 How to Cite?
AbstractGanoderma lucidum is a Chinese herbal medicine popular with cancer patients. Previous in vitro studies suggested that Ganoderma lucidum might impair hemostasis. In this prospective, randomized double-blind study, healthy volunteers received orally Ganoderma lucidum capsules 1.5 g (n = 20) or placebo (n = 20) daily for 4 wk. We monitored subjects before drug administration and at 4 and 8 wk thereafter by routine coagulation screen, fibrinogen concentration, von Willebrand ristocetin cofactor activity, platelet function analyzer PFA-100®, and thrombelastography. There were no significant between-group differences and all measurements remained within the normal range. Ganoderma lucidum ingestion over 4 wk was not associated with impairment of hemostasis. ©2005 by the International Anesthesia Research Society.
Persistent Identifierhttp://hdl.handle.net/10722/67323
ISSN
2015 Impact Factor: 3.827
2015 SCImago Journal Rankings: 1.523
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKwok, Yen_HK
dc.contributor.authorNg, KFJen_HK
dc.contributor.authorLi, CCFen_HK
dc.contributor.authorLam, CCKen_HK
dc.contributor.authorMan, RYKen_HK
dc.date.accessioned2010-09-06T05:53:58Z-
dc.date.available2010-09-06T05:53:58Z-
dc.date.issued2005en_HK
dc.identifier.citationAnesthesia And Analgesia, 2005, v. 101 n. 2, p. 423-426en_HK
dc.identifier.issn0003-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67323-
dc.description.abstractGanoderma lucidum is a Chinese herbal medicine popular with cancer patients. Previous in vitro studies suggested that Ganoderma lucidum might impair hemostasis. In this prospective, randomized double-blind study, healthy volunteers received orally Ganoderma lucidum capsules 1.5 g (n = 20) or placebo (n = 20) daily for 4 wk. We monitored subjects before drug administration and at 4 and 8 wk thereafter by routine coagulation screen, fibrinogen concentration, von Willebrand ristocetin cofactor activity, platelet function analyzer PFA-100®, and thrombelastography. There were no significant between-group differences and all measurements remained within the normal range. Ganoderma lucidum ingestion over 4 wk was not associated with impairment of hemostasis. ©2005 by the International Anesthesia Research Society.en_HK
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.orgen_HK
dc.relation.ispartofAnesthesia and Analgesiaen_HK
dc.rightsThis is a non-final version of an article published in final form in Anesthesia and Analgesia, 2005, v. 101 n. 2, p. 423-426en_HK
dc.subject.meshGanoderma - chemistry-
dc.subject.meshHemostasis - drug effects-
dc.subject.meshLanosterol - analogs and derivatives - pharmacology-
dc.subject.meshPhytotherapy - adverse effects-
dc.subject.meshvon Willebrand Factor - pharmacology-
dc.titleA prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteersen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, KFJ: jkfng@hkucc.hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1213/01.ANE.0000155286.20467.28en_HK
dc.identifier.pmid16037156-
dc.identifier.scopuseid_2-s2.0-22944445777en_HK
dc.identifier.hkuros120206en_HK
dc.identifier.hkuros103569-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22944445777&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume101en_HK
dc.identifier.issue2en_HK
dc.identifier.spage423en_HK
dc.identifier.epage426en_HK
dc.identifier.isiWOS:000230739100024-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKwok, Y=26324269400en_HK
dc.identifier.scopusauthoridNg, KFJ=13608809400en_HK
dc.identifier.scopusauthoridLi, CCF=8656496400en_HK
dc.identifier.scopusauthoridLam, CCK=16947291300en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK

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