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Article: Remifentanil preconditioning confers delayed cardioprotection in the rat

TitleRemifentanil preconditioning confers delayed cardioprotection in the rat
Authors
KeywordsAnalgesics opioid, remifentanil
Heart, ischaemia
Rat
Receptors, opioid
Issue Date2007
PublisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/
Citation
British Journal Of Anaesthesia, 2007, v. 99 n. 5, p. 632-638 How to Cite?
AbstractBackground. Preconditioning with remifentanil (RPC) provides immediate cardioprotection in rats via all three types of opioid (OP) receptor. This study sought to investigate whether remifentanil also confers delayed cardioprotection via OP receptors. Methods. Male rats received preconditioning either by ischaemia (IPC; 5 min occlusion, 5 min reperfusion × 3) or with remifentanil (RPC; 1, 5, 10, and 20 μg kg-1 min-1, 20 min infusion). After 24 h, all animals were subjected to 30 min occlusion of the left coronary artery and 2 h of reperfusion. Subsequently, the time-course effect of RPC (10 μg kg-1 min-1, 20 min infusion) was determined at 12, 16, 24, 32, 36, and 48 h intervals, using the same experimental procedure. The effect of RPC (10 μg kg-1 min -1, 20 min infusion) and IPC in the presence of selective OP receptor antagonists was evaluated at the 24 h interval. Infarct size (IS), as a percentage of the area at risk (AAR), was determined. Results. Pre-treatment with remifentanil at 1, 5, 10, and 20 μg kg-1 min-1 significantly reduced the IS/AAR at 24 h with the maximum effect at 10 μg kg-1 min-1. Remifentanil at 10 μg kg-1 min-1 significantly reduced the IS at 12 h [32.5 (sd 9.1)%]; 16 h [26.1 (2.8)%]; 24 h [19.5 (5.0)%]; 32 h [31.2 (9.1)%]; and 36 h [36.4 (9.4)%] after drug administration. The maximal reduction in IS was seen at 24 h and the effect completely disappeared at 48 h [36.4 (9.4)%]. The protective effect of RPC was abolished or significantly attenuated by blockade of any of the three OP receptors with selective antagonists. Conclusions. Like IPC, remifentanil produces delayed cardioprotection in anaesthetized rats 12-36 h after administration. The protective effect is mediated via all three OP receptors. © The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67313
ISSN
2015 Impact Factor: 5.616
2015 SCImago Journal Rankings: 2.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, CKen_HK
dc.contributor.authorLi, YHen_HK
dc.contributor.authorWong, GTCen_HK
dc.contributor.authorWong, TMen_HK
dc.contributor.authorIrwin, MGen_HK
dc.date.accessioned2010-09-06T05:53:53Z-
dc.date.available2010-09-06T05:53:53Z-
dc.date.issued2007en_HK
dc.identifier.citationBritish Journal Of Anaesthesia, 2007, v. 99 n. 5, p. 632-638en_HK
dc.identifier.issn0007-0912en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67313-
dc.description.abstractBackground. Preconditioning with remifentanil (RPC) provides immediate cardioprotection in rats via all three types of opioid (OP) receptor. This study sought to investigate whether remifentanil also confers delayed cardioprotection via OP receptors. Methods. Male rats received preconditioning either by ischaemia (IPC; 5 min occlusion, 5 min reperfusion × 3) or with remifentanil (RPC; 1, 5, 10, and 20 μg kg-1 min-1, 20 min infusion). After 24 h, all animals were subjected to 30 min occlusion of the left coronary artery and 2 h of reperfusion. Subsequently, the time-course effect of RPC (10 μg kg-1 min-1, 20 min infusion) was determined at 12, 16, 24, 32, 36, and 48 h intervals, using the same experimental procedure. The effect of RPC (10 μg kg-1 min -1, 20 min infusion) and IPC in the presence of selective OP receptor antagonists was evaluated at the 24 h interval. Infarct size (IS), as a percentage of the area at risk (AAR), was determined. Results. Pre-treatment with remifentanil at 1, 5, 10, and 20 μg kg-1 min-1 significantly reduced the IS/AAR at 24 h with the maximum effect at 10 μg kg-1 min-1. Remifentanil at 10 μg kg-1 min-1 significantly reduced the IS at 12 h [32.5 (sd 9.1)%]; 16 h [26.1 (2.8)%]; 24 h [19.5 (5.0)%]; 32 h [31.2 (9.1)%]; and 36 h [36.4 (9.4)%] after drug administration. The maximal reduction in IS was seen at 24 h and the effect completely disappeared at 48 h [36.4 (9.4)%]. The protective effect of RPC was abolished or significantly attenuated by blockade of any of the three OP receptors with selective antagonists. Conclusions. Like IPC, remifentanil produces delayed cardioprotection in anaesthetized rats 12-36 h after administration. The protective effect is mediated via all three OP receptors. © The Board of Management and Trustees of the British Journal of Anaesthesia 2007. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/en_HK
dc.relation.ispartofBritish Journal of Anaesthesiaen_HK
dc.subjectAnalgesics opioid, remifentanilen_HK
dc.subjectHeart, ischaemiaen_HK
dc.subjectRaten_HK
dc.subjectReceptors, opioiden_HK
dc.subject.meshAnalgesics, Opioid - therapeutic use-
dc.subject.meshBlood Pressure - drug effects-
dc.subject.meshIschemic Preconditioning, Myocardial - methods-
dc.subject.meshMyocardial Reperfusion Injury - prevention and control-
dc.subject.meshPiperidines - therapeutic use-
dc.titleRemifentanil preconditioning confers delayed cardioprotection in the raten_HK
dc.typeArticleen_HK
dc.identifier.emailWong, GTC:gordon@hku.hken_HK
dc.identifier.emailIrwin, MG:mgirwin@hku.hken_HK
dc.identifier.authorityWong, GTC=rp00523en_HK
dc.identifier.authorityIrwin, MG=rp00390en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/bja/aem261en_HK
dc.identifier.pmid17872933-
dc.identifier.scopuseid_2-s2.0-38449110525en_HK
dc.identifier.hkuros134952en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38449110525&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue5en_HK
dc.identifier.spage632en_HK
dc.identifier.epage638en_HK
dc.identifier.eissn1471-6771-
dc.identifier.isiWOS:000250674600007-
dc.publisher.placeUnited Kingdomen_HK

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