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Article: Changes in thrombelastograph™ variables associated with aging

TitleChanges in thrombelastograph™ variables associated with aging
Authors
Issue Date2004
PublisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.org
Citation
Anesthesia And Analgesia, 2004, v. 99 n. 2, p. 449-454 How to Cite?
AbstractAging is associated with hypercoagulability. To assess thrombelastography (TEG®) variables associated with aging, 132 adult patients of various ages undergoing orthopedic surgery for fracture repair had venous blood samples withdrawn for testing of recalcified TEG® before the induction of anesthesia. Age was weakly correlated with all TEG® variables: r time (R) (r = -0.45, P < 0.001; R = 19.5 - 0.09 × age), k time (K) (r = -0.49, P < 0.001; K = 6.5 - 0.04 × age), maximum amplitude (MA) (r = 0.25, P < 0.01; MA = 53.3 + 0.07 × age), and α (r = 0.52, P < 0.001; α = 52.8 + 0.2 × age). The correlation was stronger for men than for women. Only R was significantly correlated with age when the women were separately analyzed. Part of the correlation may be attributable to a concurrent decrease in hemoglobin with aging, but age remained an independent predictor of R, K, and α on forward stepwise linear multiple regression analysis. Aging was weakly associated with changes in TEG® variables, which should be allowed for when interpreting TEG® measurements in the elderly.
Persistent Identifierhttp://hdl.handle.net/10722/67311
ISSN
2015 Impact Factor: 3.827
2015 SCImago Journal Rankings: 1.523
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KFJen_HK
dc.date.accessioned2010-09-06T05:53:52Z-
dc.date.available2010-09-06T05:53:52Z-
dc.date.issued2004en_HK
dc.identifier.citationAnesthesia And Analgesia, 2004, v. 99 n. 2, p. 449-454en_HK
dc.identifier.issn0003-2999en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67311-
dc.description.abstractAging is associated with hypercoagulability. To assess thrombelastography (TEG®) variables associated with aging, 132 adult patients of various ages undergoing orthopedic surgery for fracture repair had venous blood samples withdrawn for testing of recalcified TEG® before the induction of anesthesia. Age was weakly correlated with all TEG® variables: r time (R) (r = -0.45, P < 0.001; R = 19.5 - 0.09 × age), k time (K) (r = -0.49, P < 0.001; K = 6.5 - 0.04 × age), maximum amplitude (MA) (r = 0.25, P < 0.01; MA = 53.3 + 0.07 × age), and α (r = 0.52, P < 0.001; α = 52.8 + 0.2 × age). The correlation was stronger for men than for women. Only R was significantly correlated with age when the women were separately analyzed. Part of the correlation may be attributable to a concurrent decrease in hemoglobin with aging, but age remained an independent predictor of R, K, and α on forward stepwise linear multiple regression analysis. Aging was weakly associated with changes in TEG® variables, which should be allowed for when interpreting TEG® measurements in the elderly.en_HK
dc.languageengen_HK
dc.publisherLippincott, Williams & Wilkins. The Journal's web site is located at http://www.anesthesia-analgesia.orgen_HK
dc.relation.ispartofAnesthesia and Analgesiaen_HK
dc.subject.meshAging - blood-
dc.subject.meshBlood Cell Count-
dc.subject.meshBody Weight-
dc.subject.meshHemoglobins - metabolism-
dc.subject.meshThrombelastography-
dc.titleChanges in thrombelastograph™ variables associated with agingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-2999&volume=99&spage=449&epage=454&date=2004&atitle=Changes+in+thrombelastograph+variables+associated+with+agingen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-2999&volume=99&spage=449&epage=454&date=2004&atitle=Changes+in+thrombelastograph+variables+associated+with+aging-
dc.identifier.emailNg, KFJ:jkfng@hkucc.hku.hken_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1213/01.ANE.0000133140.75831.1E-
dc.identifier.pmid15271723-
dc.identifier.scopuseid_2-s2.0-4043081190en_HK
dc.identifier.hkuros97325en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4043081190&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue2en_HK
dc.identifier.spage449en_HK
dc.identifier.epage454en_HK
dc.identifier.isiWOS:000222897100027-
dc.publisher.placeUnited Statesen_HK

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