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Article: Comprehensive Preoperative Evaluation of Platelet Function in Total Knee Arthroplasty Patients Taking Diclofenac

TitleComprehensive Preoperative Evaluation of Platelet Function in Total Knee Arthroplasty Patients Taking Diclofenac
Authors
Keywordsarthritis
diclofenac
NSAID
PFA-100
platelet function
Issue Date2008
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/arthroplastyjournal
Citation
Journal Of Arthroplasty, 2008, v. 23 n. 3, p. 424-430 How to Cite?
AbstractThe severity and variability of platelet dysfunction in preoperative arthritic patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) have not been well studied previously. We evaluate 30 preoperative patients taking diclofenac (group D) by routine coagulation screen, platelet count, fibrinogen concentration, thrombelastography, and PFA-100 (Dade Behring, Inc, Deerfield, IL)) platelet function analyzer. Ten patients (group P) and 30 healthy volunteers (group N) not taking NSAIDs serve as control. Diclofenac causes significant prolongation of mean PFA-100 closure times (P < .0001). However, the prolongation is highly variable; and up to 33% of patients are still having normal platelet function despite diclofenac consumption. Low body weight is a significant predictor of more severe platelet dysfunction (P < .01). Other tests are not useful. We conclude that not all patients taking NSAIDs have similar platelet dysfunction and that preoperative monitoring with PFA-100 is preferable. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67280
ISSN
2015 Impact Factor: 2.515
2015 SCImago Journal Rankings: 2.154
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KFJen_HK
dc.contributor.authorLawmin, JCen_HK
dc.contributor.authorLi, CCFen_HK
dc.contributor.authorTsang, SFen_HK
dc.contributor.authorTang, WMen_HK
dc.contributor.authorChiu, KYen_HK
dc.date.accessioned2010-09-06T05:53:35Z-
dc.date.available2010-09-06T05:53:35Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Arthroplasty, 2008, v. 23 n. 3, p. 424-430en_HK
dc.identifier.issn0883-5403en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67280-
dc.description.abstractThe severity and variability of platelet dysfunction in preoperative arthritic patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) have not been well studied previously. We evaluate 30 preoperative patients taking diclofenac (group D) by routine coagulation screen, platelet count, fibrinogen concentration, thrombelastography, and PFA-100 (Dade Behring, Inc, Deerfield, IL)) platelet function analyzer. Ten patients (group P) and 30 healthy volunteers (group N) not taking NSAIDs serve as control. Diclofenac causes significant prolongation of mean PFA-100 closure times (P < .0001). However, the prolongation is highly variable; and up to 33% of patients are still having normal platelet function despite diclofenac consumption. Low body weight is a significant predictor of more severe platelet dysfunction (P < .01). Other tests are not useful. We conclude that not all patients taking NSAIDs have similar platelet dysfunction and that preoperative monitoring with PFA-100 is preferable. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/arthroplastyjournalen_HK
dc.relation.ispartofJournal of Arthroplastyen_HK
dc.subjectarthritisen_HK
dc.subjectdiclofenacen_HK
dc.subjectNSAIDen_HK
dc.subjectPFA-100en_HK
dc.subjectplatelet functionen_HK
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - therapeutic use-
dc.subject.meshArthroplasty, Replacement, Knee-
dc.subject.meshDiclofenac - therapeutic use-
dc.subject.meshPlatelet Function Tests-
dc.subject.meshThrombelastography - drug effects-
dc.titleComprehensive Preoperative Evaluation of Platelet Function in Total Knee Arthroplasty Patients Taking Diclofenacen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0883-5403&volume=23&spage=424&epage=430&date=2008&atitle=Comprehensive+preoperative+evaluation+of+platelet+function+in+total+knee+arthro-lasty+patients+taking+disclofenacen_HK
dc.identifier.emailNg, KFJ:jkfng@hkucc.hku.hken_HK
dc.identifier.emailChiu, KY:pkychiu@hkucc.hku.hken_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.identifier.authorityChiu, KY=rp00379en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.arth.2007.04.010en_HK
dc.identifier.pmid18358383en_HK
dc.identifier.scopuseid_2-s2.0-40749108923en_HK
dc.identifier.hkuros168515en_HK
dc.identifier.hkuros151406-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40749108923&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage424en_HK
dc.identifier.epage430en_HK
dc.identifier.isiWOS:000254887900016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, KFJ=13608809400en_HK
dc.identifier.scopusauthoridLawmin, JC=6503956048en_HK
dc.identifier.scopusauthoridLi, CCF=8656496400en_HK
dc.identifier.scopusauthoridTsang, SF=7102255980en_HK
dc.identifier.scopusauthoridTang, WM=7403430820en_HK
dc.identifier.scopusauthoridChiu, KY=7202988127en_HK

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