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Article: Comparison of tramadol and tramadol/droperidol mixture for patient-controlled analgesia

TitleComparison of tramadol and tramadol/droperidol mixture for patient-controlled analgesia
Authors
Issue Date1997
PublisherCanadian Anesthesiologists' Society. The Journal's web site is located at http://www.cja-jca.org/
Citation
Canadian Journal Of Anaesthesia, 1997, v. 44 n. 8, p. 810-815 How to Cite?
AbstractPurpose: To compare the analgesic efficacy and side effects of tramadol vs tramadol and droperidol for post-operative patient-controlled analgesia (PCA). Methods: Randomised, double-blind study. Thirty-four patients undergoing elective colorectal or head and neck surgery were allocated to Group I (n = 18, PCA bolus 10 mg tramadol) or Group 2 (n = 16, PCA bolus 10 mg tramadol + 0.1 mg droperidol). Anaesthesia was induced with fentanyl and thiopentone and maintained with O2, N2O plus enflurane or isoflurane with iv morphine at doses decided by the attending anaesthetists. Muscle relaxation was achieved with atracurium or vecuronium. Patients were observed four-hourly for pain using an II-point verbal rating scale (VRS). Nausea and vomiting, and sedation were assessed using four-point scales post-operatively. Vital signs, request for rescue anti-emetic and analgesic, and overall satisfaction were recorded. Results; The mean nausea scores were lower in Group 2 (1.00 ± 1.33 vs 0.06 ± 0.25 at 0-8 hr, 1.22 ± 1.93 vs 0.06 ± 0.25 at 8-16 hr, P < 0.01; 0.81 ± 1.68 vs 0 at 32-40 hr, P < 0.05; Group I vs Group 2). The vomiting scores were also lower (0.50 ± 1.04 vs 0 at 0-8 hr, 0.67 ± 1.50 vs 0 at 8-16 hr, P < 0.05; Group 1 vs Group 2). Seven (39%) patients in Group 1, but none in in Group 2, requested rescue anti-emetic (P < 0.01). There were no difference in VRS, sedation score, overall satisfaction or vital signs. Conclusion: Tramadol and droperidol combination is superior to tramadol alone for post-operative PCA. It provides a similar quality of analgesia with less nausea and vomiting and without an increase in sedation.
Persistent Identifierhttp://hdl.handle.net/10722/67272
ISSN
2015 Impact Factor: 2.139
2015 SCImago Journal Rankings: 0.884
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KFJen_HK
dc.contributor.authorTsui, SLen_HK
dc.contributor.authorYang, JCSen_HK
dc.contributor.authorHo, ETFen_HK
dc.date.accessioned2010-09-06T05:53:30Z-
dc.date.available2010-09-06T05:53:30Z-
dc.date.issued1997en_HK
dc.identifier.citationCanadian Journal Of Anaesthesia, 1997, v. 44 n. 8, p. 810-815en_HK
dc.identifier.issn0832-610Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67272-
dc.description.abstractPurpose: To compare the analgesic efficacy and side effects of tramadol vs tramadol and droperidol for post-operative patient-controlled analgesia (PCA). Methods: Randomised, double-blind study. Thirty-four patients undergoing elective colorectal or head and neck surgery were allocated to Group I (n = 18, PCA bolus 10 mg tramadol) or Group 2 (n = 16, PCA bolus 10 mg tramadol + 0.1 mg droperidol). Anaesthesia was induced with fentanyl and thiopentone and maintained with O2, N2O plus enflurane or isoflurane with iv morphine at doses decided by the attending anaesthetists. Muscle relaxation was achieved with atracurium or vecuronium. Patients were observed four-hourly for pain using an II-point verbal rating scale (VRS). Nausea and vomiting, and sedation were assessed using four-point scales post-operatively. Vital signs, request for rescue anti-emetic and analgesic, and overall satisfaction were recorded. Results; The mean nausea scores were lower in Group 2 (1.00 ± 1.33 vs 0.06 ± 0.25 at 0-8 hr, 1.22 ± 1.93 vs 0.06 ± 0.25 at 8-16 hr, P < 0.01; 0.81 ± 1.68 vs 0 at 32-40 hr, P < 0.05; Group I vs Group 2). The vomiting scores were also lower (0.50 ± 1.04 vs 0 at 0-8 hr, 0.67 ± 1.50 vs 0 at 8-16 hr, P < 0.05; Group 1 vs Group 2). Seven (39%) patients in Group 1, but none in in Group 2, requested rescue anti-emetic (P < 0.01). There were no difference in VRS, sedation score, overall satisfaction or vital signs. Conclusion: Tramadol and droperidol combination is superior to tramadol alone for post-operative PCA. It provides a similar quality of analgesia with less nausea and vomiting and without an increase in sedation.en_HK
dc.languageengen_HK
dc.publisherCanadian Anesthesiologists' Society. The Journal's web site is located at http://www.cja-jca.org/en_HK
dc.relation.ispartofCanadian Journal of Anaesthesiaen_HK
dc.subject.meshAnalgesia, Patient-Controlled-
dc.subject.meshAnalgesics - therapeutic use-
dc.subject.meshDroperidol - administration and dosage - adverse effects - therapeutic use-
dc.subject.meshTramadol - administration and dosage - adverse effects - therapeutic use-
dc.subject.meshVomiting - chemically induced - prevention and control-
dc.titleComparison of tramadol and tramadol/droperidol mixture for patient-controlled analgesiaen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, KFJ:jkfng@hkucc.hku.hken_HK
dc.identifier.authorityNg, KFJ=rp00544en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF03013155-
dc.identifier.pmid9260007-
dc.identifier.scopuseid_2-s2.0-0030668940en_HK
dc.identifier.hkuros32570en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030668940&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue8en_HK
dc.identifier.spage810en_HK
dc.identifier.epage815en_HK
dc.identifier.isiWOS:A1997XP89700004-
dc.publisher.placeCanadaen_HK

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