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Article: Exposure to subtherapeutic concentrations of polyene antifungals suppresses the adherence of Candida species to denture acrylic

TitleExposure to subtherapeutic concentrations of polyene antifungals suppresses the adherence of Candida species to denture acrylic
Authors
Issue Date2000
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/CHE
Citation
Chemotherapy, 2000, v. 46 n. 4, p. 267-274 How to Cite?
AbstractBackground: The adherence of Candida species to denture acrylic is the initial event leading to Candida-associated denture stomatitis, with Candida albicans being the main aetiological agent. However, the increased incidence of immunocompromised patients in the community has resulted in the emergence of a number of non-albicans Candida species as causative agents of this disease, which is commonly managed by topically delivered polyene antifungals. Hence, we investigated the effect of the exposure of denture acrylic surfaces to nystatin and amphotericin B on the subsequent adhesion of six different Candida species. Methods: Acrylic strips were exposed to subtherapeutic concentrations of the two polyenes for 30 min, and the adhesion of 4 isolates each of C. albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis and Candida tropicalis was assessed using a previously described in vitro method with slight modifications. Results: Overall, the results indicated a 35.9% (p < 0.01) and 63.1% (p < 0.01) reduction, respectively, in yeast adhesion to denture acrylic following exposure to nystatin and amphotericin B, although this effect was not uniform for all the tested isolates. Thus, all C. glabrata, 3 C. guilliermondii and a single isolate each of C. krusei, C. parapsilosis and C. tropicalis were not significantly affected by nystatin exposure, and a single isolate each of C. glabrata and C. guilliermondii were not significantly affected by amphotericin B. Conclusions: The present data, the first on the effect of polyenes on a wide range of Candida species, indicate that the in vitro exposure of denture acrylic to subtherapeutic concentrations of nystatin and amphotericin B suppresses the adherence of pathogenic Candida species in general. Copyright (C) 2000 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/67225
ISSN
2015 Impact Factor: 0.992
2015 SCImago Journal Rankings: 0.630
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEgusa, Hen_HK
dc.contributor.authorEllepola, ANBen_HK
dc.contributor.authorNikawa, Hen_HK
dc.contributor.authorHamada, Ten_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:53:02Z-
dc.date.available2010-09-06T05:53:02Z-
dc.date.issued2000en_HK
dc.identifier.citationChemotherapy, 2000, v. 46 n. 4, p. 267-274en_HK
dc.identifier.issn0009-3157en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67225-
dc.description.abstractBackground: The adherence of Candida species to denture acrylic is the initial event leading to Candida-associated denture stomatitis, with Candida albicans being the main aetiological agent. However, the increased incidence of immunocompromised patients in the community has resulted in the emergence of a number of non-albicans Candida species as causative agents of this disease, which is commonly managed by topically delivered polyene antifungals. Hence, we investigated the effect of the exposure of denture acrylic surfaces to nystatin and amphotericin B on the subsequent adhesion of six different Candida species. Methods: Acrylic strips were exposed to subtherapeutic concentrations of the two polyenes for 30 min, and the adhesion of 4 isolates each of C. albicans, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis and Candida tropicalis was assessed using a previously described in vitro method with slight modifications. Results: Overall, the results indicated a 35.9% (p < 0.01) and 63.1% (p < 0.01) reduction, respectively, in yeast adhesion to denture acrylic following exposure to nystatin and amphotericin B, although this effect was not uniform for all the tested isolates. Thus, all C. glabrata, 3 C. guilliermondii and a single isolate each of C. krusei, C. parapsilosis and C. tropicalis were not significantly affected by nystatin exposure, and a single isolate each of C. glabrata and C. guilliermondii were not significantly affected by amphotericin B. Conclusions: The present data, the first on the effect of polyenes on a wide range of Candida species, indicate that the in vitro exposure of denture acrylic to subtherapeutic concentrations of nystatin and amphotericin B suppresses the adherence of pathogenic Candida species in general. Copyright (C) 2000 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/CHEen_HK
dc.relation.ispartofChemotherapyen_HK
dc.rightsChemotherapy. Copyright © S Karger AG.en_HK
dc.subject.meshAcrylic Resins - metabolismen_HK
dc.subject.meshAmphotericin B - pharmacologyen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAntifungal Agents - pharmacologyen_HK
dc.subject.meshCandida - cytology - drug effectsen_HK
dc.subject.meshCell Adhesion - drug effectsen_HK
dc.subject.meshDenturesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshNystatin - pharmacologyen_HK
dc.subject.meshPolyenes - pharmacologyen_HK
dc.titleExposure to subtherapeutic concentrations of polyene antifungals suppresses the adherence of Candida species to denture acrylicen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0009-3157&volume=46&spage=267&epage=274&date=2000&atitle=Exposure+to+subtherapeutic+concentrations+of+polyene+antifungals+suppresses+the+adherence+of+Candida+species+to+denture+acrylicen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10859432-
dc.identifier.scopuseid_2-s2.0-0033933171en_HK
dc.identifier.hkuros51667en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033933171&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue4en_HK
dc.identifier.spage267en_HK
dc.identifier.epage274en_HK
dc.identifier.isiWOS:000087838800005-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridEgusa, H=6602170721en_HK
dc.identifier.scopusauthoridEllepola, ANB=6604060863en_HK
dc.identifier.scopusauthoridNikawa, H=7006724162en_HK
dc.identifier.scopusauthoridHamada, T=7401759268en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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