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- Publisher Website: 10.1067/mod.2002.125991
- Scopus: eid_2-s2.0-0036676902
- PMID: 12165776
- WOS: WOS:000177428900021
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Article: VEGF and bone formation in the glenoid fossa during forward mandibular positioning
Title | VEGF and bone formation in the glenoid fossa during forward mandibular positioning |
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Authors | |
Issue Date | 2002 |
Publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo |
Citation | American Journal Of Orthodontics And Dentofacial Orthopedics, 2002, v. 122 n. 2, p. 202-209 How to Cite? |
Abstract | This study was designed to identify the relationship between vascularization and bone formation in the glenoid fossa during natural growth and functional appliance therapy. The temporal pattern of vascular endothelial growth factor (VEGF) expression and bone formation in the glenoid fossa during natural growth was identified and compared with that during forward mandibular positioning. We randomly divided 150 female Sprague-Dawley rats, 35 days old, into 10 experimental and 10 control groups. Appliances were fitted to position the mandible forward in the experimental groups. The rats were then killed at different times. Sections were cut and stained with anti-VEGF antibodies to evaluate VEGF expression, and with periodic acid and Schiffs reagent to evaluate new bone formation. Both VEGF expression and newly formed bone were measured by a computer-assisted image analyzing system. The results showed that, during natural growth and forward mandibular positioning, VEGF expression and new bone formation were highest in the posterior region of the glenoid fossa. There were significant increases of VEGF and new bone formation in the experimental groups compared with the controls. The highest amount of VEGF expression occurred before the highest amount of bone formation was reached. Forward mandibular positioning causes significant increases in vascularization and new bone formation in the glenoid fossa. A close correlation exists between vascularization and bone formation. Copyright © 2002 by the American Association of Orthodontists. |
Persistent Identifier | http://hdl.handle.net/10722/67222 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 1.283 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Rabie, ABM | en_HK |
dc.contributor.author | Shum, L | en_HK |
dc.contributor.author | Chayanupatkul, A | en_HK |
dc.date.accessioned | 2010-09-06T05:53:00Z | - |
dc.date.available | 2010-09-06T05:53:00Z | - |
dc.date.issued | 2002 | en_HK |
dc.identifier.citation | American Journal Of Orthodontics And Dentofacial Orthopedics, 2002, v. 122 n. 2, p. 202-209 | en_HK |
dc.identifier.issn | 0889-5406 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/67222 | - |
dc.description.abstract | This study was designed to identify the relationship between vascularization and bone formation in the glenoid fossa during natural growth and functional appliance therapy. The temporal pattern of vascular endothelial growth factor (VEGF) expression and bone formation in the glenoid fossa during natural growth was identified and compared with that during forward mandibular positioning. We randomly divided 150 female Sprague-Dawley rats, 35 days old, into 10 experimental and 10 control groups. Appliances were fitted to position the mandible forward in the experimental groups. The rats were then killed at different times. Sections were cut and stained with anti-VEGF antibodies to evaluate VEGF expression, and with periodic acid and Schiffs reagent to evaluate new bone formation. Both VEGF expression and newly formed bone were measured by a computer-assisted image analyzing system. The results showed that, during natural growth and forward mandibular positioning, VEGF expression and new bone formation were highest in the posterior region of the glenoid fossa. There were significant increases of VEGF and new bone formation in the experimental groups compared with the controls. The highest amount of VEGF expression occurred before the highest amount of bone formation was reached. Forward mandibular positioning causes significant increases in vascularization and new bone formation in the glenoid fossa. A close correlation exists between vascularization and bone formation. Copyright © 2002 by the American Association of Orthodontists. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Mosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo | en_HK |
dc.relation.ispartof | American Journal of Orthodontics and Dentofacial Orthopedics | en_HK |
dc.rights | American Journal of Orthodontics and Dentofacial Orthopedics. Copyright © Mosby, Inc. | en_HK |
dc.subject.mesh | Animals | en_HK |
dc.subject.mesh | Dental Stress Analysis | en_HK |
dc.subject.mesh | Endothelial Growth Factors - biosynthesis | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Immunohistochemistry | en_HK |
dc.subject.mesh | Lymphokines - biosynthesis | en_HK |
dc.subject.mesh | Mandibular Advancement | en_HK |
dc.subject.mesh | Neovascularization, Physiologic | en_HK |
dc.subject.mesh | Orthodontic Appliances, Functional | en_HK |
dc.subject.mesh | Osteogenesis | en_HK |
dc.subject.mesh | Rats | en_HK |
dc.subject.mesh | Rats, Sprague-Dawley | en_HK |
dc.subject.mesh | Stress, Mechanical | en_HK |
dc.subject.mesh | Temporal Bone - blood supply - growth & development - metabolism | en_HK |
dc.subject.mesh | Vascular Endothelial Growth Factor A | en_HK |
dc.subject.mesh | Vascular Endothelial Growth Factors | en_HK |
dc.title | VEGF and bone formation in the glenoid fossa during forward mandibular positioning | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-5406&volume=122&spage=202&epage=209&date=2002&atitle=VEGF+and+bone+formation+in+the+glenoid+fossa+during+forward+mandibular+positioning | en_HK |
dc.identifier.email | Rabie, ABM: rabie@hku.hk | en_HK |
dc.identifier.authority | Rabie, ABM=rp00029 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1067/mod.2002.125991 | en_HK |
dc.identifier.pmid | 12165776 | - |
dc.identifier.scopus | eid_2-s2.0-0036676902 | en_HK |
dc.identifier.hkuros | 73817 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036676902&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 122 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 202 | en_HK |
dc.identifier.epage | 209 | en_HK |
dc.identifier.isi | WOS:000177428900021 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Rabie, ABM=7007172734 | en_HK |
dc.identifier.scopusauthorid | Shum, L=7003895312 | en_HK |
dc.identifier.scopusauthorid | Chayanupatkul, A=6506338362 | en_HK |
dc.identifier.issnl | 0889-5406 | - |