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Article: VEGF and bone formation in the glenoid fossa during forward mandibular positioning

TitleVEGF and bone formation in the glenoid fossa during forward mandibular positioning
Authors
Issue Date2002
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
Citation
American Journal Of Orthodontics And Dentofacial Orthopedics, 2002, v. 122 n. 2, p. 202-209 How to Cite?
AbstractThis study was designed to identify the relationship between vascularization and bone formation in the glenoid fossa during natural growth and functional appliance therapy. The temporal pattern of vascular endothelial growth factor (VEGF) expression and bone formation in the glenoid fossa during natural growth was identified and compared with that during forward mandibular positioning. We randomly divided 150 female Sprague-Dawley rats, 35 days old, into 10 experimental and 10 control groups. Appliances were fitted to position the mandible forward in the experimental groups. The rats were then killed at different times. Sections were cut and stained with anti-VEGF antibodies to evaluate VEGF expression, and with periodic acid and Schiffs reagent to evaluate new bone formation. Both VEGF expression and newly formed bone were measured by a computer-assisted image analyzing system. The results showed that, during natural growth and forward mandibular positioning, VEGF expression and new bone formation were highest in the posterior region of the glenoid fossa. There were significant increases of VEGF and new bone formation in the experimental groups compared with the controls. The highest amount of VEGF expression occurred before the highest amount of bone formation was reached. Forward mandibular positioning causes significant increases in vascularization and new bone formation in the glenoid fossa. A close correlation exists between vascularization and bone formation. Copyright © 2002 by the American Association of Orthodontists.
Persistent Identifierhttp://hdl.handle.net/10722/67222
ISSN
2015 Impact Factor: 1.69
2015 SCImago Journal Rankings: 1.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorShum, Len_HK
dc.contributor.authorChayanupatkul, Aen_HK
dc.date.accessioned2010-09-06T05:53:00Z-
dc.date.available2010-09-06T05:53:00Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2002, v. 122 n. 2, p. 202-209en_HK
dc.identifier.issn0889-5406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67222-
dc.description.abstractThis study was designed to identify the relationship between vascularization and bone formation in the glenoid fossa during natural growth and functional appliance therapy. The temporal pattern of vascular endothelial growth factor (VEGF) expression and bone formation in the glenoid fossa during natural growth was identified and compared with that during forward mandibular positioning. We randomly divided 150 female Sprague-Dawley rats, 35 days old, into 10 experimental and 10 control groups. Appliances were fitted to position the mandible forward in the experimental groups. The rats were then killed at different times. Sections were cut and stained with anti-VEGF antibodies to evaluate VEGF expression, and with periodic acid and Schiffs reagent to evaluate new bone formation. Both VEGF expression and newly formed bone were measured by a computer-assisted image analyzing system. The results showed that, during natural growth and forward mandibular positioning, VEGF expression and new bone formation were highest in the posterior region of the glenoid fossa. There were significant increases of VEGF and new bone formation in the experimental groups compared with the controls. The highest amount of VEGF expression occurred before the highest amount of bone formation was reached. Forward mandibular positioning causes significant increases in vascularization and new bone formation in the glenoid fossa. A close correlation exists between vascularization and bone formation. Copyright © 2002 by the American Association of Orthodontists.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodoen_HK
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_HK
dc.rightsAmerican Journal of Orthodontics and Dentofacial Orthopedics. Copyright © Mosby, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshDental Stress Analysisen_HK
dc.subject.meshEndothelial Growth Factors - biosynthesisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshLymphokines - biosynthesisen_HK
dc.subject.meshMandibular Advancementen_HK
dc.subject.meshNeovascularization, Physiologicen_HK
dc.subject.meshOrthodontic Appliances, Functionalen_HK
dc.subject.meshOsteogenesisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStress, Mechanicalen_HK
dc.subject.meshTemporal Bone - blood supply - growth & development - metabolismen_HK
dc.subject.meshVascular Endothelial Growth Factor Aen_HK
dc.subject.meshVascular Endothelial Growth Factorsen_HK
dc.titleVEGF and bone formation in the glenoid fossa during forward mandibular positioningen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-5406&volume=122&spage=202&epage=209&date=2002&atitle=VEGF+and+bone+formation+in+the+glenoid+fossa+during+forward+mandibular+positioningen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1067/mod.2002.125991en_HK
dc.identifier.pmid12165776-
dc.identifier.scopuseid_2-s2.0-0036676902en_HK
dc.identifier.hkuros73817en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036676902&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume122en_HK
dc.identifier.issue2en_HK
dc.identifier.spage202en_HK
dc.identifier.epage209en_HK
dc.identifier.isiWOS:000177428900021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridShum, L=7003895312en_HK
dc.identifier.scopusauthoridChayanupatkul, A=6506338362en_HK

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