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Article: Increased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis

TitleIncreased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitis
Authors
KeywordsC-reactive protein
Endothelial function
Endothelial progenitor cells
Periodontitis
Issue Date2009
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPE
Citation
Journal Of Clinical Periodontology, 2009, v. 36 n. 11, p. 933-939 How to Cite?
AbstractAim: Emerging evidence shows that periodontal disease is associated with endothelial dysfunction. The purpose of this study was to determine the association between chronic periodontitis (CP) and circulating endothelial progenitor cells (EPC). Materials and Methods: Eighty-six non-smoking subjects (36 males and 50 females, aged 35-80 years) were recruited, including 23 subjects with no or mild CP and 63 subjects with moderate to severe CP. The levels of circulating EPC were quantitatively determined by fluorescence- activated cell analysis, including CD34+/kinase insert domain-containing receptor (KDR)+ (more mature EPC) and CD133 +/KDR+ (less mature EPC). Periodontal conditions, the intima-media thickness of carotid arteries and circulating biomarkers were examined. Results: Subjects with moderate to severe CP exhibited an increased risk of high EPC count, compared with those with no or mild CP: CD34 +/KDR+ EPC [odds ratio (OR)=9.5, 95% confidence interval (95% CI) 1.5-61.0, p=0.018; CD133+/KDR+ EPC, OR=4.6, 95% CI 1.1-19.5, p=0.039]. C-reactive protein was significantly associated with high CD34+/KDR+ EPC count and age was inversely related with high EPC count. Age, gender and CD34+/KDR+ EPC were independent variables of increased carotid intima-media thickness (p<0.05). Conclusion: This study shows for the first time that moderate to severe CP is associated with an increased level of circulating EPC. © 2009 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/67209
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848
ISI Accession Number ID
Funding AgencyGrant Number
Hong Kong Research Grants CouncilHKU 7518/05M
University of Hong Kong200507176137
200607176038
200707176095
Sun Chieh Yeh Heart Foundation
Funding Information:

This study was supported by the Hong Kong Research Grants Council (HKU 7518/05M), The University of Hong Kong (CRCG Funds 200507176137, 200607176038 and 200707176095), and the Sun Chieh Yeh Heart Foundation. The authors declare that they have no conflict of interests.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorLi, Xen_HK
dc.contributor.authorTse, HFen_HK
dc.contributor.authorYiu, KHen_HK
dc.contributor.authorJia, Nen_HK
dc.contributor.authorChen, Hen_HK
dc.contributor.authorLi, LSWen_HK
dc.contributor.authorJin, Len_HK
dc.date.accessioned2010-09-06T05:52:54Z-
dc.date.available2010-09-06T05:52:54Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal Of Clinical Periodontology, 2009, v. 36 n. 11, p. 933-939en_HK
dc.identifier.issn0303-6979en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67209-
dc.description.abstractAim: Emerging evidence shows that periodontal disease is associated with endothelial dysfunction. The purpose of this study was to determine the association between chronic periodontitis (CP) and circulating endothelial progenitor cells (EPC). Materials and Methods: Eighty-six non-smoking subjects (36 males and 50 females, aged 35-80 years) were recruited, including 23 subjects with no or mild CP and 63 subjects with moderate to severe CP. The levels of circulating EPC were quantitatively determined by fluorescence- activated cell analysis, including CD34+/kinase insert domain-containing receptor (KDR)+ (more mature EPC) and CD133 +/KDR+ (less mature EPC). Periodontal conditions, the intima-media thickness of carotid arteries and circulating biomarkers were examined. Results: Subjects with moderate to severe CP exhibited an increased risk of high EPC count, compared with those with no or mild CP: CD34 +/KDR+ EPC [odds ratio (OR)=9.5, 95% confidence interval (95% CI) 1.5-61.0, p=0.018; CD133+/KDR+ EPC, OR=4.6, 95% CI 1.1-19.5, p=0.039]. C-reactive protein was significantly associated with high CD34+/KDR+ EPC count and age was inversely related with high EPC count. Age, gender and CD34+/KDR+ EPC were independent variables of increased carotid intima-media thickness (p<0.05). Conclusion: This study shows for the first time that moderate to severe CP is associated with an increased level of circulating EPC. © 2009 John Wiley & Sons A/S.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CPEen_HK
dc.relation.ispartofJournal of Clinical Periodontologyen_HK
dc.subjectC-reactive proteinen_HK
dc.subjectEndothelial functionen_HK
dc.subjectEndothelial progenitor cellsen_HK
dc.subjectPeriodontitisen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntigens, CD - blooden_HK
dc.subject.meshAntigens, CD34 - blooden_HK
dc.subject.meshBiological Markers - blooden_HK
dc.subject.meshC-Reactive Protein - analysisen_HK
dc.subject.meshCarotid Arteries - pathologyen_HK
dc.subject.meshChronic Periodontitis - blooden_HK
dc.subject.meshEducational Statusen_HK
dc.subject.meshEndothelial Cells - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFlow Cytometryen_HK
dc.subject.meshGingival Hemorrhage - blooden_HK
dc.subject.meshGingival Recession - blooden_HK
dc.subject.meshGlycoproteins - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeptides - blooden_HK
dc.subject.meshPeriodontal Attachment Loss - blooden_HK
dc.subject.meshPeriodontal Pocket - blooden_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshStem Cells - pathologyen_HK
dc.subject.meshTunica Intima - pathologyen_HK
dc.subject.meshTunica Media - pathologyen_HK
dc.subject.meshVascular Endothelial Growth Factor Receptor-2 - blooden_HK
dc.subject.meshWaist-Hip Ratioen_HK
dc.titleIncreased levels of circulating endothelial progenitor cells in subjects with moderate to severe chronic periodontitisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0303-6979&volume=36&spage=933&epage=939&date=2009&atitle=Increased+levels+of+circulating+endothelial+progenitor+cells+in+subjects+with+moderate+to+severe+chronic+periodontitisen_HK
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_HK
dc.identifier.emailYiu, KH:khkyiu@hku.hken_HK
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_HK
dc.identifier.authorityTse, HF=rp00428en_HK
dc.identifier.authorityYiu, KH=rp01490en_HK
dc.identifier.authorityJin, L=rp00028en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2009.01481.xen_HK
dc.identifier.pmid19799717-
dc.identifier.scopuseid_2-s2.0-70350191506en_HK
dc.identifier.hkuros168203en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350191506&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume36en_HK
dc.identifier.issue11en_HK
dc.identifier.spage933en_HK
dc.identifier.epage939en_HK
dc.identifier.eissn1600-051X-
dc.identifier.isiWOS:000270900600005-
dc.publisher.placeDenmarken_HK
dc.relation.projectNovel molecular mechanisms of innate host defense - implications in periodontal health and disease-
dc.identifier.scopusauthoridLi, X=36013155200en_HK
dc.identifier.scopusauthoridTse, HF=7006070805en_HK
dc.identifier.scopusauthoridYiu, KH=35172267800en_HK
dc.identifier.scopusauthoridJia, N=35336664200en_HK
dc.identifier.scopusauthoridChen, H=7501613961en_HK
dc.identifier.scopusauthoridLi, LSW=7501450364en_HK
dc.identifier.scopusauthoridJin, L=7403328850en_HK

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