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Article: The in vivo expression of membrane-bound CD14 in periodontal health and disease

TitleThe in vivo expression of membrane-bound CD14 in periodontal health and disease
Authors
Issue Date2004
PublisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.org
Citation
Journal Of Periodontology, 2004, v. 75 n. 4, p. 578-585 How to Cite?
AbstractBackground: Membrane-bound CD14 (mCD14) is a myeloid differentiation antigen expressed on monocytes/macrophages and neutrophils. It is a key molecule responsible for the innate recognition of bacteria by host cells and functions as an important receptor for bacterial lipopolysaccharide. This study investigated the in vivo expression profile and levels of mCD14 in healthy and diseased gingival tissues. Methods: Gingival biopsies were obtained from 24 patients with chronic periodontitis, including 22 periodontal pocket tissues, 13 clinically healthy tissues, and 18 inflamed connective tissues (i.e., granulation tissues). Gingival biopsies from seven periodontally healthy subjects were used as controls. mCD14 was detected by immunohistochemistry. Results: mCD14 was detected in 21 of 22 periodontal pocket tissues and all other categories of tissues. The mCD14-positive cells were mainly confined to the gingival epithelium-connective tissue interface. The expression levels in periodontally healthy subjects were significantly higher than in the patients. Within the patients, clinically healthy tissues showed greater levels of mCD14 than periodontal pocket tissues and granulation tissues. Conclusions: mCD14 was commonly expressed in both healthy and diseased gingival tissues and was predominantly confined to the epithelium-connective tissue interface. The positive relationship observed between mCD14 expression levels and periodontal health may imply that mCD14 is associated with favorable host responses to bacterial challenge and contributes to maintaining periodontal homeostasis.
Persistent Identifierhttp://hdl.handle.net/10722/67186
ISSN
2015 Impact Factor: 2.844
2015 SCImago Journal Rankings: 1.070
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, Len_HK
dc.contributor.authorRen, Len_HK
dc.contributor.authorLeung, WKen_HK
dc.contributor.authorDarveau, RPen_HK
dc.date.accessioned2010-09-06T05:52:41Z-
dc.date.available2010-09-06T05:52:41Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Periodontology, 2004, v. 75 n. 4, p. 578-585en_HK
dc.identifier.issn0022-3492en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67186-
dc.description.abstractBackground: Membrane-bound CD14 (mCD14) is a myeloid differentiation antigen expressed on monocytes/macrophages and neutrophils. It is a key molecule responsible for the innate recognition of bacteria by host cells and functions as an important receptor for bacterial lipopolysaccharide. This study investigated the in vivo expression profile and levels of mCD14 in healthy and diseased gingival tissues. Methods: Gingival biopsies were obtained from 24 patients with chronic periodontitis, including 22 periodontal pocket tissues, 13 clinically healthy tissues, and 18 inflamed connective tissues (i.e., granulation tissues). Gingival biopsies from seven periodontally healthy subjects were used as controls. mCD14 was detected by immunohistochemistry. Results: mCD14 was detected in 21 of 22 periodontal pocket tissues and all other categories of tissues. The mCD14-positive cells were mainly confined to the gingival epithelium-connective tissue interface. The expression levels in periodontally healthy subjects were significantly higher than in the patients. Within the patients, clinically healthy tissues showed greater levels of mCD14 than periodontal pocket tissues and granulation tissues. Conclusions: mCD14 was commonly expressed in both healthy and diseased gingival tissues and was predominantly confined to the epithelium-connective tissue interface. The positive relationship observed between mCD14 expression levels and periodontal health may imply that mCD14 is associated with favorable host responses to bacterial challenge and contributes to maintaining periodontal homeostasis.en_HK
dc.languageengen_HK
dc.publisherAmerican Academy of Periodontology. The Journal's web site is located at http://www.perio.orgen_HK
dc.relation.ispartofJournal of Periodontologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAntigens, CD14 - biosynthesisen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChronic Diseaseen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGingiva - immunology - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeriodontal Pocket - immunology - metabolismen_HK
dc.subject.meshPeriodontitis - immunology - metabolismen_HK
dc.titleThe in vivo expression of membrane-bound CD14 in periodontal health and diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1671-167X&volume=75&spage=578&epage=585&date=2004&atitle=The+in+vivo+expression+of+membrane-bound+CD14+in+periodontal+health+and+diseaseen_HK
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_HK
dc.identifier.emailLeung, WK:ewkleung@hkucc.hku.hken_HK
dc.identifier.authorityJin, L=rp00028en_HK
dc.identifier.authorityLeung, WK=rp00019en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1902/jop.2004.75.4.578en_HK
dc.identifier.pmid15152823-
dc.identifier.scopuseid_2-s2.0-2442457704en_HK
dc.identifier.hkuros85618en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442457704&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue4en_HK
dc.identifier.spage578en_HK
dc.identifier.epage585en_HK
dc.identifier.isiWOS:000221157400013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJin, L=7403328850en_HK
dc.identifier.scopusauthoridRen, L=35216223200en_HK
dc.identifier.scopusauthoridLeung, WK=25224691800en_HK
dc.identifier.scopusauthoridDarveau, RP=7006419856en_HK

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