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Article: Association of matrix metalloproteinase-1 promoter polymorphism with generalized aggressive periodontitis in a Chinese population

TitleAssociation of matrix metalloproteinase-1 promoter polymorphism with generalized aggressive periodontitis in a Chinese population
Authors
Issue Date2005
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1
Citation
Journal Of Periodontal Research, 2005, v. 40 n. 6, p. 427-431 How to Cite?
AbstractBackground: A single nucleotide polymorphism in the promoter region of -1607 bp of the human matrix metalloproteinase-1 (MMP-1) gene has been found to be associated with an increased risk of various inflammatory diseases and cancer metastasis. Objectives: The present study aimed to examine the distribution of MMP-1 genotypes in a group of Chinese subjects with generalized aggressive periodontitis and a group of periodontally healthy subjects, and to evaluate the possible association of the MMP-1 promoter polymorphism with aggressive periodontitis. Methods: Genomic DNA was obtained from whole blood samples in 40 Chinese subjects with generalized aggressive periodontitis and 52 periodontally healthy subjects as controls. MMP-1 promoter fragment was amplified by polymerase chain reaction, and the polymorphisms were analyzed by restriction endonuclease cleavage. The alleles were detected by polyacrylamide gel electrophoresis and visualized with ethidium bromide. Results: The detection frequency of 2G allele was significantly higher in the subjects with generalized aggressive periodontitis (68.7%) than in the control subjects (49%) (p < 0.01). The genotype of 2G/2G was found in 52.5% of the patients, which was significantly greater than that of control subjects (23.1%) (p < 0.05). Conclusion: The present study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607 bp may be associated with generalized aggressive periodontitis in Chinese population. © Blackwell Munksgaard 2005.
Persistent Identifierhttp://hdl.handle.net/10722/67148
ISSN
2015 Impact Factor: 2.474
2015 SCImago Journal Rankings: 0.932
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCao, Zen_HK
dc.contributor.authorLi, Cen_HK
dc.contributor.authorJin, Len_HK
dc.contributor.authorCorbet, EFen_HK
dc.date.accessioned2010-09-06T05:52:22Z-
dc.date.available2010-09-06T05:52:22Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Periodontal Research, 2005, v. 40 n. 6, p. 427-431en_HK
dc.identifier.issn0022-3484en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67148-
dc.description.abstractBackground: A single nucleotide polymorphism in the promoter region of -1607 bp of the human matrix metalloproteinase-1 (MMP-1) gene has been found to be associated with an increased risk of various inflammatory diseases and cancer metastasis. Objectives: The present study aimed to examine the distribution of MMP-1 genotypes in a group of Chinese subjects with generalized aggressive periodontitis and a group of periodontally healthy subjects, and to evaluate the possible association of the MMP-1 promoter polymorphism with aggressive periodontitis. Methods: Genomic DNA was obtained from whole blood samples in 40 Chinese subjects with generalized aggressive periodontitis and 52 periodontally healthy subjects as controls. MMP-1 promoter fragment was amplified by polymerase chain reaction, and the polymorphisms were analyzed by restriction endonuclease cleavage. The alleles were detected by polyacrylamide gel electrophoresis and visualized with ethidium bromide. Results: The detection frequency of 2G allele was significantly higher in the subjects with generalized aggressive periodontitis (68.7%) than in the control subjects (49%) (p < 0.01). The genotype of 2G/2G was found in 52.5% of the patients, which was significantly greater than that of control subjects (23.1%) (p < 0.05). Conclusion: The present study suggests that a single nucleotide polymorphism in the MMP-1 promoter region of -1607 bp may be associated with generalized aggressive periodontitis in Chinese population. © Blackwell Munksgaard 2005.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0022-3484&site=1en_HK
dc.relation.ispartofJournal of Periodontal Researchen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAllelesen_HK
dc.subject.meshBase Pairing - geneticsen_HK
dc.subject.meshChinaen_HK
dc.subject.meshDNA - analysisen_HK
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMatrix Metalloproteinase 1 - geneticsen_HK
dc.subject.meshPeriodontitis - enzymologyen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_HK
dc.subject.meshPolymorphism, Single Nucleotide - geneticsen_HK
dc.subject.meshPromoter Regions, Genetic - geneticsen_HK
dc.titleAssociation of matrix metalloproteinase-1 promoter polymorphism with generalized aggressive periodontitis in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0022-3484&volume=40&spage=427&epage=431&date=2005&atitle=Association+of+matrix+metalloproteinase-1+promoter+polymorphism+with+generalized+aggressive+periodontitis+in+a+Chinese+populationen_HK
dc.identifier.emailJin, L:ljjin@hkucc.hku.hken_HK
dc.identifier.emailCorbet, EF:efcorbet@hku.hken_HK
dc.identifier.authorityJin, L=rp00028en_HK
dc.identifier.authorityCorbet, EF=rp00005en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-0765.2005.00806.xen_HK
dc.identifier.pmid16302919-
dc.identifier.scopuseid_2-s2.0-27944467945en_HK
dc.identifier.hkuros111083en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27944467945&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue6en_HK
dc.identifier.spage427en_HK
dc.identifier.epage431en_HK
dc.identifier.isiWOS:000232893600001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCao, Z=8642062400en_HK
dc.identifier.scopusauthoridLi, C=15728225200en_HK
dc.identifier.scopusauthoridJin, L=7403328850en_HK
dc.identifier.scopusauthoridCorbet, EF=35609873200en_HK
dc.identifier.citeulike371833-

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