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Article: Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model

TitleEffect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model
Authors
Issue Date2006
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/ten
Citation
Tissue Engineering, 2006, v. 12 n. 11, p. 3181-3188 How to Cite?
AbstractThis study aims to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Eighteen New Zealand white rabbits were assigned to 2 groups, 1 treated at a routine distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). rhBMP-2 was injected into 1 side of the distraction regenerate at the end of the active distraction period; the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and histologic examination. The results showed that rhBMP-2 can promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the bone morphogenetic protein injection sides of the rapid and routine distraction groups. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both routine and rapid distraction rates. The addition of rhBMP-2 seems to be able to compensate for the rapid distraction rate in mandibular distraction osteogenesis. Further long-term follow-up and mechanical strength test for the support of implants or conventional prostheses are necessary. © Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/67109
ISSN
2013 Impact Factor: 4.254
2010 SCImago Journal Rankings: 1.962
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, WZen_HK
dc.contributor.authorLim, KCen_HK
dc.date.accessioned2010-09-06T05:52:02Z-
dc.date.available2010-09-06T05:52:02Z-
dc.date.issued2006en_HK
dc.identifier.citationTissue Engineering, 2006, v. 12 n. 11, p. 3181-3188en_HK
dc.identifier.issn1076-3279en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67109-
dc.description.abstractThis study aims to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Eighteen New Zealand white rabbits were assigned to 2 groups, 1 treated at a routine distraction rate (0.9 mm/d) and the other at a rapid distraction rate (2.7 mm/d). rhBMP-2 was injected into 1 side of the distraction regenerate at the end of the active distraction period; the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, microcomputed tomography, and histologic examination. The results showed that rhBMP-2 can promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the bone morphogenetic protein injection sides of the rapid and routine distraction groups. In conclusion, the study indicates that rhBMP-2 can enhance bone ossification at both routine and rapid distraction rates. The addition of rhBMP-2 seems to be able to compensate for the rapid distraction rate in mandibular distraction osteogenesis. Further long-term follow-up and mechanical strength test for the support of implants or conventional prostheses are necessary. © Mary Ann Liebert, Inc.en_HK
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/tenen_HK
dc.relation.ispartofTissue Engineeringen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Morphogenetic Protein 2en_HK
dc.subject.meshBone Morphogenetic Proteins - genetics - pharmacology - therapeutic useen_HK
dc.subject.meshBone Regeneration - drug effects - physiologyen_HK
dc.subject.meshBone Remodeling - drug effects - physiologyen_HK
dc.subject.meshHistocytochemistryen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshMandible - drug effects - metabolism - physiopathology - radiography - surgeryen_HK
dc.subject.meshModels, Animalen_HK
dc.subject.meshOsteogenesis - drug effects - physiologyen_HK
dc.subject.meshOsteogenesis, Distraction - methodsen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRecombinant Proteins - pharmacologyen_HK
dc.subject.meshTomography, X-Ray Computeden_HK
dc.subject.meshTransforming Growth Factor beta - genetics - pharmacology - therapeutic useen_HK
dc.titleEffect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit modelen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1076-3279&volume=12&spage=3181&epage=3188&date=2006&atitle=Effect+of+recombinant+human+bone+morphogenetic+protein-2+on+mandibular+distraction+at+different+rates+in+a+rabbit+modelen_HK
dc.identifier.emailLi, WZ:lwzheng@hku.hken_HK
dc.identifier.authorityLi, WZ=rp01411en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1089/ten.2006.12.3181en_HK
dc.identifier.pmid17518632-
dc.identifier.scopuseid_2-s2.0-33751576552en_HK
dc.identifier.hkuros127036en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33751576552&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue11en_HK
dc.identifier.spage3181en_HK
dc.identifier.epage3188en_HK
dc.identifier.eissn2152-4955-
dc.identifier.isiWOS:000242400200016-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, WZ=11241247300en_HK
dc.identifier.scopusauthoridLim, KC=15119192900en_HK

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