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Article: Post-antifungal effect of polyene, azole and DNA-analogue agents against oral Candida albicans and Candida tropicalis isolates in HIV disease

TitlePost-antifungal effect of polyene, azole and DNA-analogue agents against oral Candida albicans and Candida tropicalis isolates in HIV disease
Authors
Issue Date2001
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JOPM
Citation
Journal Of Oral Pathology And Medicine, 2001, v. 30 n. 8, p. 481-488 How to Cite?
AbstractOropharyngeal candidiasis (OPC) is the most frequent AIDS-associated opportunistic infection, as up to 90% of HIV-infected individuals suffer at least one episode during the course of their disease. Various in vivo and in vitro procedures have been used to assess the effectiveness of antifungal agents used in HIV infection. In the present study, we evaluated in vitro the minimum inhibitory concentration (MIC) and the post-antifungal effect (PAFE) of two polyenes, two azoles and one DNA-analogue against 10 oral isolates of Candida albicans and 10 of Candida tropicalis, all from HIV-infected individuals, in order to obtain basic data on the pharmacodynamics of these drugs. One-hour exposure to twice the MIC of all the drugs, except fluconazole, elicited a consistently high PAFE in both Candida species. Furthermore, the PAFE elicited by the antifungals (except fluconazole) was significantly prolonged for C. tropicalis compared with C. albicans. This speedy recovery of C. albicans isolates exposed to transient low concentrations of antifungals appeared to reflect its virulence compared with lesser potent species, such as C. tropicalis. Taken together, the current data, while confirming the existence of PAFE in a non-albicans species of Candida, also provide further clues for the recalcitrance of C. albicans species in the face of antifungal therapy for oropharyngeal candidiasis.
Persistent Identifierhttp://hdl.handle.net/10722/67107
ISSN
2015 Impact Factor: 1.859
2015 SCImago Journal Rankings: 0.731
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnil, Sen_HK
dc.contributor.authorEllepola, ANBen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:52:01Z-
dc.date.available2010-09-06T05:52:01Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Oral Pathology And Medicine, 2001, v. 30 n. 8, p. 481-488en_HK
dc.identifier.issn0904-2512en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67107-
dc.description.abstractOropharyngeal candidiasis (OPC) is the most frequent AIDS-associated opportunistic infection, as up to 90% of HIV-infected individuals suffer at least one episode during the course of their disease. Various in vivo and in vitro procedures have been used to assess the effectiveness of antifungal agents used in HIV infection. In the present study, we evaluated in vitro the minimum inhibitory concentration (MIC) and the post-antifungal effect (PAFE) of two polyenes, two azoles and one DNA-analogue against 10 oral isolates of Candida albicans and 10 of Candida tropicalis, all from HIV-infected individuals, in order to obtain basic data on the pharmacodynamics of these drugs. One-hour exposure to twice the MIC of all the drugs, except fluconazole, elicited a consistently high PAFE in both Candida species. Furthermore, the PAFE elicited by the antifungals (except fluconazole) was significantly prolonged for C. tropicalis compared with C. albicans. This speedy recovery of C. albicans isolates exposed to transient low concentrations of antifungals appeared to reflect its virulence compared with lesser potent species, such as C. tropicalis. Taken together, the current data, while confirming the existence of PAFE in a non-albicans species of Candida, also provide further clues for the recalcitrance of C. albicans species in the face of antifungal therapy for oropharyngeal candidiasis.en_HK
dc.languageengen_HK
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JOPMen_HK
dc.relation.ispartofJournal of Oral Pathology and Medicineen_HK
dc.subject.meshAIDS-Related Opportunistic Infections - drug therapyen_HK
dc.subject.meshAmphotericin B - pharmacology - therapeutic useen_HK
dc.subject.meshAntifungal Agents - pharmacology - therapeutic useen_HK
dc.subject.meshCandida - classification - drug effectsen_HK
dc.subject.meshCandida albicans - drug effects - pathogenicityen_HK
dc.subject.meshCandidiasis, Oral - drug therapyen_HK
dc.subject.meshFluconazole - pharmacology - therapeutic useen_HK
dc.subject.meshFlucytosine - pharmacology - therapeutic useen_HK
dc.subject.meshHIV Infections - complicationsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshKetoconazole - pharmacology - therapeutic useen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshNystatin - pharmacology - therapeutic useen_HK
dc.subject.meshOropharynx - microbiologyen_HK
dc.subject.meshPharyngeal Diseases - microbiologyen_HK
dc.subject.meshStatistics as Topicen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshVirulenceen_HK
dc.titlePost-antifungal effect of polyene, azole and DNA-analogue agents against oral Candida albicans and Candida tropicalis isolates in HIV diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0904-2512&volume=30&spage=481&epage=8&date=2000&atitle=Post-antifungal+effect+of+polyene,+azole+and+DNA-analogue+agents+against+oral+Candida+albicans+and+Candida+tropicalis+isolates+in+HIV+diseaseen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11545239en_HK
dc.identifier.scopuseid_2-s2.0-0034863352en_HK
dc.identifier.hkuros62639en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034863352&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue8en_HK
dc.identifier.spage481en_HK
dc.identifier.epage488en_HK
dc.identifier.isiWOS:000170481700005-
dc.publisher.placeDenmarken_HK
dc.identifier.scopusauthoridAnil, S=7006640037en_HK
dc.identifier.scopusauthoridEllepola, ANB=6604060863en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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