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Article: Topical and systemic antibiotics in the management of periodontal diseases

TitleTopical and systemic antibiotics in the management of periodontal diseases
Authors
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1875-595X
Citation
International Dental Journal, 2004, v. 54 n. 1, p. 3-14 How to Cite?
AbstractBoth systemic and topical antibiotics are increasingly used in the management of periodontal infections. Whilst these drugs are used mostly on an empirical basis, some contend that rational use of antibiotics should be the norm due to their wide abuse and consequential global emergence of antibiotic resistance organisms. Here we review the rationale and principles of antimicrobial therapy, treatment goals, drug delivery routes and various antibiotics that are used in the management of periodontal diseases. The pros and cons of systemic and local antibiotic therapy are described together with practical guidelines for their delivery. The available data indicate, in general, that mechanical periodontal treatment alone is adequate to ameliorate or resolve the clinical condition in most cases, but adjunctive antimicrobial agents, delivered either locally or systemically, can enhance the effect of therapy in specific situations. This is particularly true for aggressive (early onset) periodontitis, in patients with generalised systemic disease that may affect host resistance and in case of poor response to conventional mechanical therapy. Locally delivered antibiotics together with mechanical debridement are indicated for non-responding sites of focal infection or in localised recurrent disease. After resolution of the periodontal infection, the patient should be placed on an individually tailored maintenance care programme. Optimal plaque control by the patient is of paramount importance for a favourable clinical and microbiological response to any form of periodontal therapy.
Persistent Identifierhttp://hdl.handle.net/10722/67097
ISSN
2015 Impact Factor: 0.967
2015 SCImago Journal Rankings: 0.512
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMombelli, Aen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:51:56Z-
dc.date.available2010-09-06T05:51:56Z-
dc.date.issued2004en_HK
dc.identifier.citationInternational Dental Journal, 2004, v. 54 n. 1, p. 3-14en_HK
dc.identifier.issn0020-6539en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67097-
dc.description.abstractBoth systemic and topical antibiotics are increasingly used in the management of periodontal infections. Whilst these drugs are used mostly on an empirical basis, some contend that rational use of antibiotics should be the norm due to their wide abuse and consequential global emergence of antibiotic resistance organisms. Here we review the rationale and principles of antimicrobial therapy, treatment goals, drug delivery routes and various antibiotics that are used in the management of periodontal diseases. The pros and cons of systemic and local antibiotic therapy are described together with practical guidelines for their delivery. The available data indicate, in general, that mechanical periodontal treatment alone is adequate to ameliorate or resolve the clinical condition in most cases, but adjunctive antimicrobial agents, delivered either locally or systemically, can enhance the effect of therapy in specific situations. This is particularly true for aggressive (early onset) periodontitis, in patients with generalised systemic disease that may affect host resistance and in case of poor response to conventional mechanical therapy. Locally delivered antibiotics together with mechanical debridement are indicated for non-responding sites of focal infection or in localised recurrent disease. After resolution of the periodontal infection, the patient should be placed on an individually tailored maintenance care programme. Optimal plaque control by the patient is of paramount importance for a favourable clinical and microbiological response to any form of periodontal therapy.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1875-595Xen_HK
dc.relation.ispartofInternational Dental Journalen_HK
dc.subject.meshActinobacillus Infections - drug therapyen_HK
dc.subject.meshActinobacillus actinomycetemcomitans - drug effectsen_HK
dc.subject.meshAdministration, Oralen_HK
dc.subject.meshAdministration, Topicalen_HK
dc.subject.meshAnti-Bacterial Agents - administration & dosageen_HK
dc.subject.meshAnti-Infective Agents, Local - administration & dosageen_HK
dc.subject.meshBacteroidaceae Infections - drug therapyen_HK
dc.subject.meshChlorhexidine - administration & dosage - analogs & derivativesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMetronidazole - administration & dosageen_HK
dc.subject.meshPeriodontitis - drug therapy - microbiologyen_HK
dc.subject.meshPorphyromonas gingivalis - drug effectsen_HK
dc.subject.meshTetracycline - administration & dosageen_HK
dc.titleTopical and systemic antibiotics in the management of periodontal diseasesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-6539&volume=54&spage=3&epage=14&date=2004&atitle=Topical+and+systemic+antibiotics+in+the+management+of+periodontal+diseasesen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15005467-
dc.identifier.scopuseid_2-s2.0-1342281629en_HK
dc.identifier.hkuros85598en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342281629&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue1en_HK
dc.identifier.spage3en_HK
dc.identifier.epage14en_HK
dc.identifier.isiWOS:000227831300001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMombelli, A=7006180872en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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