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Article: Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation

TitleEffect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation
Authors
KeywordsBone graft
Buguzhi extract
Collagen
Issue Date2010
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567
Citation
Phytotherapy Research, 2010, v. 24 SUPPL. 2, p. S155-S160 How to Cite?
AbstractThe objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 mm, were created in the parietal bone of 9 New Zealand white rabbits. Six defects were grafted with Buguzhi extract mixed with collagen matrix. Six defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were sacrificed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells was made on 100 sections (50 sections for each group) using image analysis. A total of 275% more new bone was present in defects grafted with Buguzhi extract in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control group. The amount of bone cells was also significantly greater in the Buguzhi group than in the positive control group. To conclude, Buguzhi extract in collagen matrix has the effect of increasing new bone formation locally in vivo. Buguzhi extract in collagen matrix can be used as a bone graft material. Copyright © 2009 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/67093
ISSN
2015 Impact Factor: 2.694
2015 SCImago Journal Rankings: 0.842
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong10208640/36170/08000/310/01
Funding Information:

This study was funded by University Research Grant No: 10208640/36170/08000/310/01, the University of Hong Kong.

References
Errata

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:51:54Z-
dc.date.available2010-09-06T05:51:54Z-
dc.date.issued2010en_HK
dc.identifier.citationPhytotherapy Research, 2010, v. 24 SUPPL. 2, p. S155-S160en_HK
dc.identifier.issn0951-418Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/67093-
dc.description.abstractThe objective of the study is to compare the amount of new bone produced by Buguzhi (Psoralea corylifolia fruit) extract in collagen matrix to that produced and collagen matrix in vivo. Eighteen bone defects, 5 mm by 10 mm, were created in the parietal bone of 9 New Zealand white rabbits. Six defects were grafted with Buguzhi extract mixed with collagen matrix. Six defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were sacrificed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation and bone cells was made on 100 sections (50 sections for each group) using image analysis. A total of 275% more new bone was present in defects grafted with Buguzhi extract in collagen matrix than those grafted with collagen matrix. No bone was formed in the negative control group. The amount of bone cells was also significantly greater in the Buguzhi group than in the positive control group. To conclude, Buguzhi extract in collagen matrix has the effect of increasing new bone formation locally in vivo. Buguzhi extract in collagen matrix can be used as a bone graft material. Copyright © 2009 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/12567en_HK
dc.relation.ispartofPhytotherapy Researchen_HK
dc.rightsPhytotherapy Research. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectBone graften_HK
dc.subjectBuguzhi extracten_HK
dc.subjectCollagenen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCollagen - pharmacologyen_HK
dc.subject.meshDrugs, Chinese Herbal - pharmacologyen_HK
dc.subject.meshFruit - chemistryen_HK
dc.subject.meshOsteogenesis - drug effectsen_HK
dc.subject.meshParietal Bone - drug effects - pathologyen_HK
dc.subject.meshPlant Extracts - pharmacologyen_HK
dc.subject.meshPsoralea - chemistryen_HK
dc.subject.meshRabbitsen_HK
dc.titleEffect of Buguzhi (Psoralea corylifolia fruit) extract on bone formationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0951-418X&volume=&spage=&epage=&date=2009&atitle=Effect+of+Buguzhi+(Psoralea+corylifolia+fruit)+Extract+on+Bone+Formationen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ptr.3049en_HK
dc.identifier.doi10.1002/ptr.3253-
dc.identifier.pmid19953524-
dc.identifier.scopuseid_2-s2.0-77953895506en_HK
dc.identifier.hkuros168355en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953895506&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issueSUPPL. 2en_HK
dc.identifier.spageS155en_HK
dc.identifier.epageS160en_HK
dc.identifier.isiWOS:000279801000006-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.erratumdoi:10.1002/ptr.3253-
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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