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Article: Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction osteogenesis

TitleEffect of recombinant human bone morphogenetic protein-2 on mandibular distraction osteogenesis
Authors
KeywordsBone morphogenetic proteins
Mandible
Osteogenesis
Distraction
Rabbits
Issue Date2007
PublisherHong Kong Dental Association. The Journal's web site is located at http://www.hkda.org/hkdj/index.php
Citation
Hong Kong Dental Journal, 2007, v. 4 n. 2, p. 94-100 How to Cite?
AbstractObjective. This study aimed to evaluate the effect of recombinant human bone morphogenetic protein- 2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Methods. Eighteen New Zealand white rabbits were randomly assigned to two groups, one treated at a routine distraction rate (0.9 mm/day) and the other at a rapid distraction rate (2.7 mm/day). The rhBMP-2 was injected into one side of the distraction regenerate at the end of the active distraction period, the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, micro-computed tomography and histological examination. Results. The rhBMP-2 appears to promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the BMP injection sides of the rapid and routine distraction groups. Conclusion. This study indicates that rhBMP-2 can enhance bone formation at both routine and rapid distraction rates. Addition of rhBMP-2 seems able to compensate for the adverse effects of rapid distraction rates on mandibular distraction osteogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/67067
ISSN

 

DC FieldValueLanguage
dc.contributor.authorZheng, Len_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-06T05:51:41Z-
dc.date.available2010-09-06T05:51:41Z-
dc.date.issued2007en_HK
dc.identifier.citationHong Kong Dental Journal, 2007, v. 4 n. 2, p. 94-100en_HK
dc.identifier.issn1727-2300en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67067-
dc.description.abstractObjective. This study aimed to evaluate the effect of recombinant human bone morphogenetic protein- 2 (rhBMP-2) on mandibular distraction at routine and rapid distraction rates. Methods. Eighteen New Zealand white rabbits were randomly assigned to two groups, one treated at a routine distraction rate (0.9 mm/day) and the other at a rapid distraction rate (2.7 mm/day). The rhBMP-2 was injected into one side of the distraction regenerate at the end of the active distraction period, the contralateral side was used as a control. The distraction regenerates were analyzed by plain radiography, micro-computed tomography and histological examination. Results. The rhBMP-2 appears to promote bone formation at both rapid and routine distraction rates, but no statistically significant difference was observed between the BMP injection sides of the rapid and routine distraction groups. Conclusion. This study indicates that rhBMP-2 can enhance bone formation at both routine and rapid distraction rates. Addition of rhBMP-2 seems able to compensate for the adverse effects of rapid distraction rates on mandibular distraction osteogenesis.-
dc.languageengen_HK
dc.publisherHong Kong Dental Association. The Journal's web site is located at http://www.hkda.org/hkdj/index.phpen_HK
dc.relation.ispartofHong Kong Dental Journalen_HK
dc.subjectBone morphogenetic proteins-
dc.subjectMandible-
dc.subjectOsteogenesis-
dc.subjectDistraction-
dc.subjectRabbits-
dc.titleEffect of recombinant human bone morphogenetic protein-2 on mandibular distraction osteogenesisen_HK
dc.typeArticleen_HK
dc.identifier.emailZheng, L: lwzheng@hku.hken_HK
dc.identifier.emailCheung, LK: lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, L=rp01411en_HK
dc.identifier.hkuros140731en_HK
dc.identifier.volume4-
dc.identifier.issue2-
dc.identifier.spage94-
dc.identifier.epage100-
dc.publisher.placeHong Kong-

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