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Article: A new approach to control condylar growth by regulating angiogenesis

TitleA new approach to control condylar growth by regulating angiogenesis
Authors
Li, QFRabie, ABM
KeywordsAngiogenesis
Angiostatin
Condylar growth
Craniofacial growth deformities
Endostatin
FGF
rAAV
Stem cells
VEGF
Issue Date2007
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 2007, v. 52 n. 11, p. 1009-1017 How to Cite?
DOI: http://dx.doi.org/10.1016/j.archoralbio.2007.05.009
AbstractObjective: To provide a comprehensive review of the mechanisms of growth of mandibular condyle, the roles of angiogenesis enhancers and inhibitors during endochondral ossification in mandibular condyle and newly developed delivery methods for local gene delivery that may represent strategies to regulate condylar growth. Design: Narrative review. Results: Angiogenesis is the crucial step in mandibular condylar growth for it regulates the transformation from cartilage to bone. Angiognesis enhancers, especially VEGF and FGF, play important roles in the process of new blood lumen formation and invasion. On the other hand, angiostatin and endostatin inhibit angiogenesis by targeting endothelial cells and several signal cascades. Delivery methods such as liposomes, stem cells and virus vectors have been studied. Recombinant AAV-mediated gene therapy is considered as one of the most promising strategies of condylar growth management. Conclusion: AAV-mediated gene therapy using VEGF or angiogenesis inhibitor will be a promising way to regulate condylar growth at an early stage. © 2007 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/67031
ISSN
0003-9969
2023 Impact Factor: 2.2
2023 SCImago Journal Rankings: 0.562
ISI Accession Number ID
WOS:000250858500001
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, QFen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:51:23Z-
dc.date.available2010-09-06T05:51:23Z-
dc.date.issued2007en_HK
dc.identifier.citationArchives Of Oral Biology, 2007, v. 52 n. 11, p. 1009-1017en_HK
dc.identifier.issn0003-9969en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67031-
dc.description.abstractObjective: To provide a comprehensive review of the mechanisms of growth of mandibular condyle, the roles of angiogenesis enhancers and inhibitors during endochondral ossification in mandibular condyle and newly developed delivery methods for local gene delivery that may represent strategies to regulate condylar growth. Design: Narrative review. Results: Angiogenesis is the crucial step in mandibular condylar growth for it regulates the transformation from cartilage to bone. Angiognesis enhancers, especially VEGF and FGF, play important roles in the process of new blood lumen formation and invasion. On the other hand, angiostatin and endostatin inhibit angiogenesis by targeting endothelial cells and several signal cascades. Delivery methods such as liposomes, stem cells and virus vectors have been studied. Recombinant AAV-mediated gene therapy is considered as one of the most promising strategies of condylar growth management. Conclusion: AAV-mediated gene therapy using VEGF or angiogenesis inhibitor will be a promising way to regulate condylar growth at an early stage. © 2007 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_HK
dc.relation.ispartofArchives of Oral Biologyen_HK
dc.subjectAngiogenesisen_HK
dc.subjectAngiostatinen_HK
dc.subjectCondylar growthen_HK
dc.subjectCraniofacial growth deformitiesen_HK
dc.subjectEndostatinen_HK
dc.subjectFGFen_HK
dc.subjectrAAVen_HK
dc.subjectStem cellsen_HK
dc.subjectVEGFen_HK
dc.subject.meshAngiogenesis Inhibitors - geneticsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCartilage - growth & developmenten_HK
dc.subject.meshDependovirus - geneticsen_HK
dc.subject.meshGene Therapy - methodsen_HK
dc.subject.meshGenetic Vectors - administration & dosageen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIntercellular Signaling Peptides and Proteins - geneticsen_HK
dc.subject.meshMandibular Condyle - abnormalities - blood supply - growth & developmenten_HK
dc.subject.meshNanotechnologyen_HK
dc.subject.meshNeovascularization, Physiologicen_HK
dc.subject.meshStem Cell Transplantationen_HK
dc.titleA new approach to control condylar growth by regulating angiogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9969&volume=52&spage=1009&epage=1017&date=2007&atitle=A+new+approach+to+control+condylar+growth+by+regulating+angiogenesisen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.archoralbio.2007.05.009en_HK
dc.identifier.pmid17640614-
dc.identifier.scopuseid_2-s2.0-34848847811en_HK
dc.identifier.hkuros143936en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34848847811&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue11en_HK
dc.identifier.spage1009en_HK
dc.identifier.epage1017en_HK
dc.identifier.isiWOS:000250858500001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, QF=22135394000en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.issnl0003-9969-

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