Article: Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants

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TitleEvaluation of functional dynamics during osseointegration and regeneration associated with oral implants
AuthorsChang, PC1 3 4
Lang, NP2
Giannobile, WV1 4
Issue Date2010
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
CitationClinical Oral Implants Research, 2010, v. 21 n. 1, p. 1-12 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2009.01826.x
AbstractObjectives: The aim of this paper is to review current investigations on functional assessments of osseointegration and assess correlations to the peri-implant structure. Material and methods: The literature was electronically searched for studies of promoting dental implant osseointegration, functional assessments of implant stability, and finite element (FE) analyses in the field of implant dentistry, and any references regarding biological events during osseointegration were also cited as background information. Results: Osseointegration involves a cascade of protein and cell apposition, vascular invasion, de novo bone formation and maturation to achieve the primary and secondary dental implant stability. This process may be accelerated by alteration of the implant surface roughness, developing a biomimetric interface, or local delivery of growth-promoting factors. The current available pre-clinical and clinical biomechanical assessments demonstrated a variety of correlations to the peri-implant structural parameters, and functionally integrated peri-implant structure through FE optimization can offer strong correlation to the interfacial biomechanics. Conclusions: The progression of osseointegration may be accelerated by alteration of the implant interface as well as growth factor applications, and functional integration of peri-implant structure may be feasible to predict the implant function during osseointegration. More research in this field is still needed. © 2009 John Wiley & Sons A/S.
ISSN0905-7161
2011 Impact Factor: 2.514
2011 SCImago Journal Rankings: 0.117
DOIhttp://dx.doi.org/10.1111/j.1600-0501.2009.01826.x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChang, PC
dc.contributor.authorLang, NP
dc.contributor.authorGiannobile, WV
dc.date.accessioned2010-09-06T05:51:20Z
dc.date.available2010-09-06T05:51:20Z
dc.date.issued2010
dc.description.abstractObjectives: The aim of this paper is to review current investigations on functional assessments of osseointegration and assess correlations to the peri-implant structure. Material and methods: The literature was electronically searched for studies of promoting dental implant osseointegration, functional assessments of implant stability, and finite element (FE) analyses in the field of implant dentistry, and any references regarding biological events during osseointegration were also cited as background information. Results: Osseointegration involves a cascade of protein and cell apposition, vascular invasion, de novo bone formation and maturation to achieve the primary and secondary dental implant stability. This process may be accelerated by alteration of the implant surface roughness, developing a biomimetric interface, or local delivery of growth-promoting factors. The current available pre-clinical and clinical biomechanical assessments demonstrated a variety of correlations to the peri-implant structural parameters, and functionally integrated peri-implant structure through FE optimization can offer strong correlation to the interfacial biomechanics. Conclusions: The progression of osseointegration may be accelerated by alteration of the implant interface as well as growth factor applications, and functional integration of peri-implant structure may be feasible to predict the implant function during osseointegration. More research in this field is still needed. © 2009 John Wiley & Sons A/S.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationClinical Oral Implants Research, 2010, v. 21 n. 1, p. 1-12 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1600-0501.2009.01826.x
dc.identifier.citeulike6422459
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0501.2009.01826.x
dc.identifier.epage12
dc.identifier.hkuros169089
dc.identifier.isiWOS:000272835900001
Funding AgencyGrant Number
AO Foundation Research Advisory Council
NIH/NIDCRDE 13397
Funding Information:

Funding: This study was supported by the AO Foundation Research Advisory Council and NIH/NIDCR DE 13397.

dc.identifier.issn0905-7161
2011 Impact Factor: 2.514
2011 SCImago Journal Rankings: 0.117
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid20070743
dc.identifier.scopuseid_2-s2.0-72949099261
dc.identifier.spage1
dc.identifier.urihttp://hdl.handle.net/10722/67026
dc.identifier.volume21
dc.languageeng
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CLR
dc.publisher.placeUnited States
dc.relation.ispartofClinical Oral Implants Research
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshBiomechanics
dc.subject.meshDental Implantation, Endosseous
dc.subject.meshDental Implants
dc.subject.meshFinite Element Analysis
dc.subject.meshHumans
dc.subject.meshIntercellular Signaling Peptides and Proteins - pharmacology
dc.subject.meshOsseointegration - physiology
dc.subject.meshSurface Properties
dc.titleEvaluation of functional dynamics during osseointegration and regeneration associated with oral implants
dc.typeArticle
Author Affiliations
  1. University Michigan Ann Arbor
  2. The University of Hong Kong
  3. National University of Singapore
  4. University of Michigan School of Dentistry