File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness

TitleAntifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness
Authors
KeywordsAntifungal resistance
Biofilm
C. albicans
Surface roughness
Titanium
Issue Date2007
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00784/index.htm
Citation
Clinical Oral Investigations, 2007, v. 11 n. 4, p. 361-368 How to Cite?
AbstractAlthough it is well known that fungal biofilms have increased resistance to antimicrobial agents, limited information is available on the formation of candidal biofilms on implant surfaces with different surface roughness and their resistance to conventional antifungal therapy. In the current study, the effect of increasing the surface roughness of titanium discs on the susceptibility of Candida albicans biofilms to amphotericin B was determined. Grade I commercially pure titanium discs were sandblasted with 99.6% aluminium oxide of different grit sizes, producing surface roughness of 0.90, 1.88 and 3.82 μm (Groups A, B and C), respectively (P < 0.001). The antifungal susceptibility of C. albicans biofilm grown on different Ti discs was determined using XTT assay. The 50% reduction in metabolic activity (50% RMA) of planktonic C. albicans (0.5 μg/mL) was much lower than those from Groups A, B and C (2, 16, 2 μg/mL, respectively), while the 50% RMA from Group B was three-fold higher than those from Groups A and C. In conclusion, difference in titanium surface roughness was associated with variations in the antifungal resistance of the candidal biofilm. Group C appeared to have an optimum surface roughness for biofilm resistance. © Springer-Verlag 2007.
Persistent Identifierhttp://hdl.handle.net/10722/67001
ISSN
2015 Impact Factor: 2.207
2015 SCImago Journal Rankings: 0.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTsang, CSPen_HK
dc.contributor.authorNg, Hen_HK
dc.contributor.authorMcMillan, ASen_HK
dc.date.accessioned2010-09-06T05:51:08Z-
dc.date.available2010-09-06T05:51:08Z-
dc.date.issued2007en_HK
dc.identifier.citationClinical Oral Investigations, 2007, v. 11 n. 4, p. 361-368en_HK
dc.identifier.issn1432-6981en_HK
dc.identifier.urihttp://hdl.handle.net/10722/67001-
dc.description.abstractAlthough it is well known that fungal biofilms have increased resistance to antimicrobial agents, limited information is available on the formation of candidal biofilms on implant surfaces with different surface roughness and their resistance to conventional antifungal therapy. In the current study, the effect of increasing the surface roughness of titanium discs on the susceptibility of Candida albicans biofilms to amphotericin B was determined. Grade I commercially pure titanium discs were sandblasted with 99.6% aluminium oxide of different grit sizes, producing surface roughness of 0.90, 1.88 and 3.82 μm (Groups A, B and C), respectively (P < 0.001). The antifungal susceptibility of C. albicans biofilm grown on different Ti discs was determined using XTT assay. The 50% reduction in metabolic activity (50% RMA) of planktonic C. albicans (0.5 μg/mL) was much lower than those from Groups A, B and C (2, 16, 2 μg/mL, respectively), while the 50% RMA from Group B was three-fold higher than those from Groups A and C. In conclusion, difference in titanium surface roughness was associated with variations in the antifungal resistance of the candidal biofilm. Group C appeared to have an optimum surface roughness for biofilm resistance. © Springer-Verlag 2007.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00784/index.htmen_HK
dc.relation.ispartofClinical Oral Investigationsen_HK
dc.subjectAntifungal resistanceen_HK
dc.subjectBiofilmen_HK
dc.subjectC. albicansen_HK
dc.subjectSurface roughnessen_HK
dc.subjectTitaniumen_HK
dc.subject.meshAluminum Oxide - chemistryen_HK
dc.subject.meshAmphotericin B - therapeutic useen_HK
dc.subject.meshAntifungal Agents - therapeutic useen_HK
dc.subject.meshBiofilms - drug effectsen_HK
dc.subject.meshCandida albicans - drug effects - physiologyen_HK
dc.subject.meshDental Etching - methodsen_HK
dc.subject.meshDental Materials - chemistryen_HK
dc.subject.meshDrug Resistance, Fungalen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIndicators and Reagentsen_HK
dc.subject.meshMaterials Testingen_HK
dc.subject.meshParticle Sizeen_HK
dc.subject.meshSurface Propertiesen_HK
dc.subject.meshTetrazolium Salts - diagnostic useen_HK
dc.subject.meshTitanium - chemistryen_HK
dc.titleAntifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughnessen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1432-6981&volume=11&issue=4&spage=361&epage=8&date=2007&atitle=Antifungal+susceptibility+of+Candida+albicans+biofilms+on+titanium+discs+with+different+surface+roughnessen_HK
dc.identifier.emailTsang, CSP: csptsang@hkucc.hku.hken_HK
dc.identifier.emailMcMillan, AS: annemcmillan@hku.hken_HK
dc.identifier.authorityTsang, CSP=rp00026en_HK
dc.identifier.authorityMcMillan, AS=rp00014en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00784-007-0122-3en_HK
dc.identifier.pmid17522902-
dc.identifier.scopuseid_2-s2.0-36348937762en_HK
dc.identifier.hkuros149194en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36348937762&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume11en_HK
dc.identifier.issue4en_HK
dc.identifier.spage361en_HK
dc.identifier.epage368en_HK
dc.identifier.eissn1436-3771-
dc.identifier.isiWOS:000251009800007-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridTsang, CSP=7202936002en_HK
dc.identifier.scopusauthoridNg, H=23009623400en_HK
dc.identifier.scopusauthoridMcMillan, AS=7102843317en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats