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Article: Does the degree of advancement during functional appliance therapy matter?

TitleDoes the degree of advancement during functional appliance therapy matter?
Authors
Issue Date2008
PublisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/
Citation
European Journal Of Orthodontics, 2008, v. 30 n. 3, p. 274-282 How to Cite?
AbstractThe aim of this study was to assess the effect of varied degrees of mandibular advancement on condylar growth. Three hundred and thirty five 35-day-old female Sprague-Dawley rats were randomly divided into 10 experimental groups (n = 10) and five control groups (n = 5) for analysis of new bone formation and 10 experimental groups (n = 14) and five control groups (n = 14) for molecular analysis. The experimental animals were fitted with bite-jumping appliance to advance the mandible 2 and 4 mm. The rats were sacrificed on days 3, 7, 14, 21, and 30. A computer-assisted image analysing system was used to assess the quantity of new condylar bone formation. Molecular analysis utilizing real-time reverse transcription-polymerase chain reaction was used to assess the different levels of mRNA expression of different growth markers in the condyle.One-way analysis of variance (ANOVA), with a Bonferroni multiple comparison test, showed significantly more newly formed bone in the 4 mm group compared with the 2 mm and control groups on days 21 and 30 (P < 0.05). Most of the examined growth markers demonstrated a significant increase during the 4 mm advancement (P < 0.05). Indian hedgehog (Ihh) mRNA showed a 7- and 5-fold change, parathyroid hormone-related peptide (PTHrP) a 5.2- and 3-fold change and type II collagen a 9.6- and 3.7-fold change in the 4 and 2 mm advancement groups, respectively.Varied degrees of mandibular advancement result in different quantities of new bone formation and levels of expression of growth members: Ihh, PTHrP, and type II collagen. © The Author 2008. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66990
ISSN
2015 Impact Factor: 1.44
2015 SCImago Journal Rankings: 1.090
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorAlKalaly, Aen_HK
dc.date.accessioned2010-09-06T05:51:02Z-
dc.date.available2010-09-06T05:51:02Z-
dc.date.issued2008en_HK
dc.identifier.citationEuropean Journal Of Orthodontics, 2008, v. 30 n. 3, p. 274-282en_HK
dc.identifier.issn0141-5387en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66990-
dc.description.abstractThe aim of this study was to assess the effect of varied degrees of mandibular advancement on condylar growth. Three hundred and thirty five 35-day-old female Sprague-Dawley rats were randomly divided into 10 experimental groups (n = 10) and five control groups (n = 5) for analysis of new bone formation and 10 experimental groups (n = 14) and five control groups (n = 14) for molecular analysis. The experimental animals were fitted with bite-jumping appliance to advance the mandible 2 and 4 mm. The rats were sacrificed on days 3, 7, 14, 21, and 30. A computer-assisted image analysing system was used to assess the quantity of new condylar bone formation. Molecular analysis utilizing real-time reverse transcription-polymerase chain reaction was used to assess the different levels of mRNA expression of different growth markers in the condyle.One-way analysis of variance (ANOVA), with a Bonferroni multiple comparison test, showed significantly more newly formed bone in the 4 mm group compared with the 2 mm and control groups on days 21 and 30 (P < 0.05). Most of the examined growth markers demonstrated a significant increase during the 4 mm advancement (P < 0.05). Indian hedgehog (Ihh) mRNA showed a 7- and 5-fold change, parathyroid hormone-related peptide (PTHrP) a 5.2- and 3-fold change and type II collagen a 9.6- and 3.7-fold change in the 4 and 2 mm advancement groups, respectively.Varied degrees of mandibular advancement result in different quantities of new bone formation and levels of expression of growth members: Ihh, PTHrP, and type II collagen. © The Author 2008. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://ejo.oxfordjournals.org/en_HK
dc.relation.ispartofEuropean Journal of Orthodonticsen_HK
dc.rightsEuropean Journal of Orthodontics. Copyright © Oxford University Press.en_HK
dc.subject.meshAdaptation, Physiologicalen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Matrix - metabolismen_HK
dc.subject.meshCollagen Type II - genetics - metabolismen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHedgehog Proteins - genetics - metabolismen_HK
dc.subject.meshMalocclusion - therapyen_HK
dc.subject.meshMandibular Advancement - instrumentation - methodsen_HK
dc.subject.meshMandibular Condyle - growth & development - metabolismen_HK
dc.subject.meshOrthodontic Appliances, Functionalen_HK
dc.subject.meshOsteogenesis - physiologyen_HK
dc.subject.meshParathyroid Hormone-Related Protein - genetics - metabolismen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStress, Mechanicalen_HK
dc.titleDoes the degree of advancement during functional appliance therapy matter?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0141-5387&volume=30&spage=274&epage=282&date=2008&atitle=Does+the+degree+of+advancement+during+functional+appliance+therapy+matter?en_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/ejo/cjm129en_HK
dc.identifier.pmid18343894-
dc.identifier.scopuseid_2-s2.0-52449087175en_HK
dc.identifier.hkuros153149en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-52449087175&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue3en_HK
dc.identifier.spage274en_HK
dc.identifier.epage282en_HK
dc.identifier.isiWOS:000256759900009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridAlKalaly, A=24922819100en_HK

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