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Article: Statin collagen grafts used to repair defects in the parietal bone of rabbits

TitleStatin collagen grafts used to repair defects in the parietal bone of rabbits
Authors
KeywordsBone graft
Bone induction
Collagen
Statin
Issue Date2003
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom
Citation
British Journal Of Oral And Maxillofacial Surgery, 2003, v. 41 n. 4, p. 244-248 How to Cite?
AbstractWe compared the amount of new bone produced by statin collagen grafts with that produced by collagen grafts. Fifteen bone defects were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, five defects were grafted with simvastatin dissolved in water for injection mixed with absorbable collagen sponge. In the control groups, five defects were grafted with water for injection mixed with absorbable collagen sponge alone (active control) and five were left empty (passive control). Animals were killed on day 14 and the defects were prepared for histological assessment. Serial sections were cut across the whole defect. Quantitative analysis of new bone formation was made on 100 sections using image analysis. A total of 308% more new bone was present in defects grafted with statin collagen grafts than those grafted with collagen grafts alone (P < 0.0001). No bone was formed in the passive control group. In conclusion, statin collagen grafts were osteoinductive and can be used as a material for bone grafts. © 2003 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66989
ISSN
2015 Impact Factor: 1.237
2015 SCImago Journal Rankings: 0.887
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:51:02Z-
dc.date.available2010-09-06T05:51:02Z-
dc.date.issued2003en_HK
dc.identifier.citationBritish Journal Of Oral And Maxillofacial Surgery, 2003, v. 41 n. 4, p. 244-248en_HK
dc.identifier.issn0266-4356en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66989-
dc.description.abstractWe compared the amount of new bone produced by statin collagen grafts with that produced by collagen grafts. Fifteen bone defects were created in the parietal bone of nine New Zealand White rabbits. In the experimental group, five defects were grafted with simvastatin dissolved in water for injection mixed with absorbable collagen sponge. In the control groups, five defects were grafted with water for injection mixed with absorbable collagen sponge alone (active control) and five were left empty (passive control). Animals were killed on day 14 and the defects were prepared for histological assessment. Serial sections were cut across the whole defect. Quantitative analysis of new bone formation was made on 100 sections using image analysis. A total of 308% more new bone was present in defects grafted with statin collagen grafts than those grafted with collagen grafts alone (P < 0.0001). No bone was formed in the passive control group. In conclusion, statin collagen grafts were osteoinductive and can be used as a material for bone grafts. © 2003 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjomen_HK
dc.relation.ispartofBritish Journal of Oral and Maxillofacial Surgeryen_HK
dc.subjectBone graften_HK
dc.subjectBone inductionen_HK
dc.subjectCollagenen_HK
dc.subjectStatinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Morphogenetic Protein 2en_HK
dc.subject.meshBone Morphogenetic Proteins - physiologyen_HK
dc.subject.meshBone Regeneration - drug effectsen_HK
dc.subject.meshBone Transplantation - methodsen_HK
dc.subject.meshFibrillar Collagens - pharmacologyen_HK
dc.subject.meshHydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacologyen_HK
dc.subject.meshParietal Bone - surgeryen_HK
dc.subject.meshPharmaceutical Vehiclesen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshSimvastatin - pharmacologyen_HK
dc.subject.meshTransforming Growth Factor betaen_HK
dc.titleStatin collagen grafts used to repair defects in the parietal bone of rabbitsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0266-4356&volume=41&spage=244&epage=248&date=2003&atitle=Statin+collagen+grafts+used+to+repair+defects+in+the+parietal+bone+of+rabbitsen_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0266-4356(03)00081-0en_HK
dc.identifier.pmid12946667-
dc.identifier.scopuseid_2-s2.0-0141725406en_HK
dc.identifier.hkuros80085en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141725406&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue4en_HK
dc.identifier.spage244en_HK
dc.identifier.epage248en_HK
dc.identifier.isiWOS:000185591600008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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