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Article: Matrix metalloproteinase-9 regulates graft bone resorption

TitleMatrix metalloproteinase-9 regulates graft bone resorption
Authors
KeywordsAllogenic IM bone
Autogenous EC bone
Autogenous IM bone
Bone resorption
MMP-9
Issue Date2006
PublisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/
Citation
Angle Orthodontist, 2006, v. 76 n. 4, p. 598-604 How to Cite?
AbstractObjective: To explore the relationship between bone resorption and matrix metalloproteinase-9 (MMP-9) expression in autogenous and allogenic bone grafts. Materials and Methods: A total of 18 critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Three groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, and allogenic IM bone. Three months later, the defects were retrieved for quantitative analysis on the basis of histology, immunohistochemistry, and in situ hybridization. Results: A close relationship existed between MMP-9 expression and graft bone resorption. The parallel between MMP-9 expression and graft bone resorption suggested that bone resorption was accomplished in part by increased MMP-9 production evident in preosteoclasts and osteoclasts. Conclusions: MMP-9 plays an important role in graft bone resorption. Autogenous EC bone grafts express higher levels of MMP-9 leading to more resorption than autogenous or allogenic IM bone grafts. © 2005 by The EH Angle Education and Research Foundation, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/66984
ISSN
2015 Impact Factor: 1.579
2015 SCImago Journal Rankings: 1.254
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLu, Men_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:50:59Z-
dc.date.available2010-09-06T05:50:59Z-
dc.date.issued2006en_HK
dc.identifier.citationAngle Orthodontist, 2006, v. 76 n. 4, p. 598-604en_HK
dc.identifier.issn0003-3219en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66984-
dc.description.abstractObjective: To explore the relationship between bone resorption and matrix metalloproteinase-9 (MMP-9) expression in autogenous and allogenic bone grafts. Materials and Methods: A total of 18 critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Three groups of six defects each were grafted with autogenous endochondral (EC) bone, autogenous intramembranous (IM) bone, and allogenic IM bone. Three months later, the defects were retrieved for quantitative analysis on the basis of histology, immunohistochemistry, and in situ hybridization. Results: A close relationship existed between MMP-9 expression and graft bone resorption. The parallel between MMP-9 expression and graft bone resorption suggested that bone resorption was accomplished in part by increased MMP-9 production evident in preosteoclasts and osteoclasts. Conclusions: MMP-9 plays an important role in graft bone resorption. Autogenous EC bone grafts express higher levels of MMP-9 leading to more resorption than autogenous or allogenic IM bone grafts. © 2005 by The EH Angle Education and Research Foundation, Inc.en_HK
dc.languageengen_HK
dc.publisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/en_HK
dc.relation.ispartofAngle Orthodontisten_HK
dc.subjectAllogenic IM boneen_HK
dc.subjectAutogenous EC boneen_HK
dc.subjectAutogenous IM boneen_HK
dc.subjectBone resorptionen_HK
dc.subjectMMP-9en_HK
dc.subject.meshAcid Phosphatase - analysisen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBiological Markers - analysisen_HK
dc.subject.meshBone Marrow Transplantation - pathologyen_HK
dc.subject.meshBone Resorption - enzymologyen_HK
dc.subject.meshBone Transplantation - classification - pathologyen_HK
dc.subject.meshCytoplasm - enzymologyen_HK
dc.subject.meshGene Expression Regulation, Enzymologicen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshIsoenzymes - analysisen_HK
dc.subject.meshMandible - surgeryen_HK
dc.subject.meshMatrix Metalloproteinase 9 - analysis - physiologyen_HK
dc.subject.meshOsteoclasts - enzymologyen_HK
dc.subject.meshPeriodic Acid-Schiff Reactionen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTransplantation, Autologousen_HK
dc.subject.meshTransplantation, Homologousen_HK
dc.titleMatrix metalloproteinase-9 regulates graft bone resorptionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-3219&volume=2006&spage=598&epage=604&date=2006&atitle=Matrix+metalloproteinase-9+regulates+graft+bone+resorptionen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16808565-
dc.identifier.scopuseid_2-s2.0-33746013789en_HK
dc.identifier.hkuros124248en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746013789&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue4en_HK
dc.identifier.spage598en_HK
dc.identifier.epage604en_HK
dc.identifier.isiWOS:000239016800009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLu, M=7402821078en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

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