File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Article: Effects of valeriana officinalis extract on rat depressive model

TitleEffects of valeriana officinalis extract on rat depressive model
Authors
KeywordsValeriana officinalis extract
Depression
Rat
Issue Date2008
PublisherHong Kong Medical Technologies Publisher. The Journal's web site is located at http://journal.9med.net/qikan/guokanll_zzxq.php?id=210
Citation
Journal of Chinese Clinical Medicine, 2008, v. 3 n. 7, p. 374-378 How to Cite?
AbstractOBJECTIVE To invesigate the effects of Valeriana officinalis extract on behaviours, 5-hydroxytryptamine level and cell proliferation at cerebral higgocampus of a depressive rat model induced by chronic mild stress. METHODS Seventy male Sprague-Dawley rats were divided into 7 groups (10 per group) including normal control group, untreated depressive rat model group, negative control group, positive control group, low dosage Valeriana officinalis extract group, medium dosage Valeriana officinalis extract group and high dosage Valeriana officinalis extract group. All groups were examined by weight, tap water intake and 1% sucrose intake once a week. The rats were killed after week 7. The hippocampal tissues of brain for half of the groups were removed for detection of 5-hydroxytryptamine level. In the other half, the neural cells in hippocampus were detected by bromodeoxyuridine labelling and neutral red staining. RESULTS Low dosage Valeriana officinalis extract could make behaviors of depressive rats, the 5-hydroxytryptamine level and cell proliferation at hippocampus of these rats recovered to normal status. CONCLUSION Valeriana officinalis extract has high potential to be developed to be an effective antidepressant.
Persistent Identifierhttp://hdl.handle.net/10722/66977
ISSN
2014 SCImago Journal Rankings: 0.103

 

DC FieldValueLanguage
dc.contributor.authorTang, JYen_HK
dc.contributor.authorZeng, YSen_HK
dc.contributor.authorChung, Pen_HK
dc.contributor.authorWong, Ren_HK
dc.contributor.authorHagg, Uen_HK
dc.date.accessioned2010-09-06T05:50:56Z-
dc.date.available2010-09-06T05:50:56Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal of Chinese Clinical Medicine, 2008, v. 3 n. 7, p. 374-378en_HK
dc.identifier.issn1562-9023-
dc.identifier.urihttp://hdl.handle.net/10722/66977-
dc.description.abstractOBJECTIVE To invesigate the effects of Valeriana officinalis extract on behaviours, 5-hydroxytryptamine level and cell proliferation at cerebral higgocampus of a depressive rat model induced by chronic mild stress. METHODS Seventy male Sprague-Dawley rats were divided into 7 groups (10 per group) including normal control group, untreated depressive rat model group, negative control group, positive control group, low dosage Valeriana officinalis extract group, medium dosage Valeriana officinalis extract group and high dosage Valeriana officinalis extract group. All groups were examined by weight, tap water intake and 1% sucrose intake once a week. The rats were killed after week 7. The hippocampal tissues of brain for half of the groups were removed for detection of 5-hydroxytryptamine level. In the other half, the neural cells in hippocampus were detected by bromodeoxyuridine labelling and neutral red staining. RESULTS Low dosage Valeriana officinalis extract could make behaviors of depressive rats, the 5-hydroxytryptamine level and cell proliferation at hippocampus of these rats recovered to normal status. CONCLUSION Valeriana officinalis extract has high potential to be developed to be an effective antidepressant.-
dc.languageengen_HK
dc.publisherHong Kong Medical Technologies Publisher. The Journal's web site is located at http://journal.9med.net/qikan/guokanll_zzxq.php?id=210-
dc.relation.ispartofJournal of Chinese Clinical Medicineen_HK
dc.subjectValeriana officinalis extract-
dc.subjectDepression-
dc.subjectRat-
dc.titleEffects of valeriana officinalis extract on rat depressive modelen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, R: fyoung@hku.hken_HK
dc.identifier.emailHagg, EUO: euohagg@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityHagg, EUO=rp00020en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.volume3-
dc.identifier.issue7-
dc.identifier.spage374-
dc.identifier.epage378-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats