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Article: In vitro susceptibility of Candida species to lactoferrin

TitleIn vitro susceptibility of Candida species to lactoferrin
Authors
Issue Date1999
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13693786.asp
Citation
Medical Mycology, 1999, v. 37 n. 1, p. 35-41 How to Cite?
AbstractLactoferrin is an antimicrobial protein present in human mucosal secretions as well as saliva. As there is no information on the relative fungicidal activity of human and bovine lactoferrin, an oral isolate of Candida albicans was studied for its susceptibility to these two proteins. Exposure to a concentration of 20 μg ml-1 of either HLF or BLF at 37°C inactivated the yeast to the same degree irrespective of the incubation time of 45, 90 or 150 min. A similar study, using 20 μg ml-1 BLF and an incubation time of 150 min, elicited varying anticandidal activity against 35 isolates belonging to six different Candida species. Thus, BLF was fungicidal for the six Candida species in the following decreasing order; C. tropicalis > C. krusei > C. albicans > C. guilliermondii > C. parapsilosis > C. glabrata; the latter being the most resistant. These Candida species also demonstrated significant intra-species variation in susceptibility to the protein (P < 0.05). When the yeast cells exposed to BLF were examined by cryo-scanning electron microscopy, profound cell wall changes such as cell surface blebs, swelling and cell collapse were noted. These findings suggest that lactoferrin, a constituent of saliva, may differentially modulate the carriage of Candida species in the oral cavity.
Persistent Identifierhttp://hdl.handle.net/10722/66934
ISSN
2015 Impact Factor: 2.644
2015 SCImago Journal Rankings: 1.055
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXu, YYen_HK
dc.contributor.authorSamaranayake, YHen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorNikawa, Hen_HK
dc.date.accessioned2010-09-06T05:50:34Z-
dc.date.available2010-09-06T05:50:34Z-
dc.date.issued1999en_HK
dc.identifier.citationMedical Mycology, 1999, v. 37 n. 1, p. 35-41en_HK
dc.identifier.issn1369-3786en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66934-
dc.description.abstractLactoferrin is an antimicrobial protein present in human mucosal secretions as well as saliva. As there is no information on the relative fungicidal activity of human and bovine lactoferrin, an oral isolate of Candida albicans was studied for its susceptibility to these two proteins. Exposure to a concentration of 20 μg ml-1 of either HLF or BLF at 37°C inactivated the yeast to the same degree irrespective of the incubation time of 45, 90 or 150 min. A similar study, using 20 μg ml-1 BLF and an incubation time of 150 min, elicited varying anticandidal activity against 35 isolates belonging to six different Candida species. Thus, BLF was fungicidal for the six Candida species in the following decreasing order; C. tropicalis > C. krusei > C. albicans > C. guilliermondii > C. parapsilosis > C. glabrata; the latter being the most resistant. These Candida species also demonstrated significant intra-species variation in susceptibility to the protein (P < 0.05). When the yeast cells exposed to BLF were examined by cryo-scanning electron microscopy, profound cell wall changes such as cell surface blebs, swelling and cell collapse were noted. These findings suggest that lactoferrin, a constituent of saliva, may differentially modulate the carriage of Candida species in the oral cavity.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/13693786.aspen_HK
dc.relation.ispartofMedical Mycologyen_HK
dc.rightsMedical Mycology. Copyright © Informa Healthcare.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCandida - drug effects - isolation & purification - ultrastructureen_HK
dc.subject.meshCandidiasis, Oral - microbiologyen_HK
dc.subject.meshCattleen_HK
dc.subject.meshDose-Response Relationship, Drugen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLactoferrin - pharmacologyen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.titleIn vitro susceptibility of Candida species to lactoferrinen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1369-3786&volume=37&spage=35&epage=41&date=1999&atitle=In+vitro+susceptibility+of+Candida+species+to+lactoferrinen_HK
dc.identifier.emailSamaranayake, YH:hema@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, YH=rp00025en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-280X.1999.00198.xen_HK
dc.identifier.pmid10200932-
dc.identifier.scopuseid_2-s2.0-0033023416en_HK
dc.identifier.hkuros39962en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033023416&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue1en_HK
dc.identifier.spage35en_HK
dc.identifier.epage41en_HK
dc.identifier.isiWOS:000079342800005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridXu, YY=7407814405en_HK
dc.identifier.scopusauthoridSamaranayake, YH=6602677237en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridNikawa, H=7006724162en_HK

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