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Article: Effect of experimental pain from trigeminal muscle and skin on motor cortex excitability in humans

TitleEffect of experimental pain from trigeminal muscle and skin on motor cortex excitability in humans
Authors
KeywordsExperimental pain
Masseter muscle
Transcranial magnetic stimulation
Trigeminal physiology
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2000, v. 882 n. 1-2, p. 120-127 How to Cite?
AbstractThe pathophysiology of many orofacial pain syndromes is still unclear. We investigated the effect of tonic muscle and skin pain on the excitability of the trigeminal motor pathways using transcranial magnetic stimulation (TMS). Motor evoked potentials (MEPs) were recorded in the masseter surface electromyogram (EMG). Magnetic pulses were delivered with a large coil at intensities 1.1 and 1.5 times the motor threshold, and for each intensity, MEPs were recorded at three different clenching levels: 15, 30 and 45% of maximum voluntary contraction (MVC). Baseline, pain and post-baseline recordings were compared in two sessions. Firstly, muscle pain was induced by infusion of hypertonic saline (5.8%) into the left masseter. Secondly, skin pain was induced by topical application of capsaicin (5%) on the left cheek. Muscle and skin pain did not induce significant effects on the amplitude or latency of the MEPs (ANOVAs: P > 0.50). In both sessions, the amplitude of the MEPs increased with the increase of the clenching level and stimulus intensity (P < 0.0001; P < 0.005) whereas the latency was not significantly changed (P > 0.05; P = 0.11). Muscle pain was associated with an increase in the pre-stimulus EMG activity on the non-painful side compared with baseline (P < 0.01), which could be due to compensatory changes in the activation of the painful muscle. The need for voluntary contraction to evoke MEPs in the masseter muscles and compensatory mechanisms both at the brainstem and cortical level might explain the lack of detectable modulation of MEPs. Nonetheless, the present findings did not support the so-called 'vicious cycle' between pain - central hyperexcitability - muscle hyperactivity. (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/66829
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRomaniello, Aen_HK
dc.contributor.authorCruccu, Gen_HK
dc.contributor.authorMcMillan, ASen_HK
dc.contributor.authorArendtNielsen, Len_HK
dc.contributor.authorSvensson, Pen_HK
dc.date.accessioned2010-09-06T05:49:42Z-
dc.date.available2010-09-06T05:49:42Z-
dc.date.issued2000en_HK
dc.identifier.citationBrain Research, 2000, v. 882 n. 1-2, p. 120-127en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66829-
dc.description.abstractThe pathophysiology of many orofacial pain syndromes is still unclear. We investigated the effect of tonic muscle and skin pain on the excitability of the trigeminal motor pathways using transcranial magnetic stimulation (TMS). Motor evoked potentials (MEPs) were recorded in the masseter surface electromyogram (EMG). Magnetic pulses were delivered with a large coil at intensities 1.1 and 1.5 times the motor threshold, and for each intensity, MEPs were recorded at three different clenching levels: 15, 30 and 45% of maximum voluntary contraction (MVC). Baseline, pain and post-baseline recordings were compared in two sessions. Firstly, muscle pain was induced by infusion of hypertonic saline (5.8%) into the left masseter. Secondly, skin pain was induced by topical application of capsaicin (5%) on the left cheek. Muscle and skin pain did not induce significant effects on the amplitude or latency of the MEPs (ANOVAs: P > 0.50). In both sessions, the amplitude of the MEPs increased with the increase of the clenching level and stimulus intensity (P < 0.0001; P < 0.005) whereas the latency was not significantly changed (P > 0.05; P = 0.11). Muscle pain was associated with an increase in the pre-stimulus EMG activity on the non-painful side compared with baseline (P < 0.01), which could be due to compensatory changes in the activation of the painful muscle. The need for voluntary contraction to evoke MEPs in the masseter muscles and compensatory mechanisms both at the brainstem and cortical level might explain the lack of detectable modulation of MEPs. Nonetheless, the present findings did not support the so-called 'vicious cycle' between pain - central hyperexcitability - muscle hyperactivity. (C) 2000 Elsevier Science B.V.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subjectExperimental painen_HK
dc.subjectMasseter muscleen_HK
dc.subjectTranscranial magnetic stimulationen_HK
dc.subjectTrigeminal physiologyen_HK
dc.titleEffect of experimental pain from trigeminal muscle and skin on motor cortex excitability in humansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=882&spage=120&epage=127&date=2000&atitle=Effect+of+experimental+pain+from+trigeminal+muscle+and+skin+on+motor+cortex+excitability+in+humans.en_HK
dc.identifier.emailMcMillan, AS: annemcmillan@hku.hken_HK
dc.identifier.authorityMcMillan, AS=rp00014en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0006-8993(00)02856-0en_HK
dc.identifier.pmid11056191-
dc.identifier.scopuseid_2-s2.0-0034602108en_HK
dc.identifier.hkuros58733en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034602108&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume882en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage120en_HK
dc.identifier.epage127en_HK
dc.identifier.isiWOS:000165161900014-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridRomaniello, A=35549799300en_HK
dc.identifier.scopusauthoridCruccu, G=24293056600en_HK
dc.identifier.scopusauthoridMcMillan, AS=7102843317en_HK
dc.identifier.scopusauthoridArendtNielsen, L=7102885673en_HK
dc.identifier.scopusauthoridSvensson, P=7103121346en_HK

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