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Article: The antifungal effect of lactoferrin and lysozyme on Candida krusei and Candida albicans

TitleThe antifungal effect of lactoferrin and lysozyme on Candida krusei and Candida albicans
Authors
Issue Date1997
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMIS
Citation
Apmis, 1997, v. 105 n. 11, p. 875-883 How to Cite?
AbstractLactoferrin and lysozyme (muramidase) are non-immune defence factors present in various exocrine secretions, including saliva. Previous studies have shown that both proteins, either singly or in combination, are bactericidal in nature and their combined activity is synergistic. As little is known of their interactions with Candida species, 20 oral isolates of C. krusei and 5 isolates of C. albicans were studied for their susceptibility to human apo-lactoferrin and lysozyme, either singly or in combination, using an in vitro assay system. The two species exhibited significant interspecies differences in susceptibility to lactoferrin (p < 0.05), but not for lysozyme. C. krusei being more sensitive to lactoferrin (c 1.4 times) than C. albicans. Both species revealed significant intraspecies differences in their susceptibility to lysozyme (p < 0.05), but not for lactoferrin. No synergistic antifungal activity of the two proteins on either Candida species was noted. The results imply that the variable expression of the fungicidal activity of lactoferrin and lysozyme on Candida species may modulate the oral carriage of yeasts in a complex manner.
Persistent Identifierhttp://hdl.handle.net/10722/66825
ISSN
2015 Impact Factor: 1.933
2015 SCImago Journal Rankings: 0.855
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSamaranayake, YHen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorWu, PCen_HK
dc.contributor.authorSo, Men_HK
dc.date.accessioned2010-09-06T05:49:40Z-
dc.date.available2010-09-06T05:49:40Z-
dc.date.issued1997en_HK
dc.identifier.citationApmis, 1997, v. 105 n. 11, p. 875-883en_HK
dc.identifier.issn0903-4641en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66825-
dc.description.abstractLactoferrin and lysozyme (muramidase) are non-immune defence factors present in various exocrine secretions, including saliva. Previous studies have shown that both proteins, either singly or in combination, are bactericidal in nature and their combined activity is synergistic. As little is known of their interactions with Candida species, 20 oral isolates of C. krusei and 5 isolates of C. albicans were studied for their susceptibility to human apo-lactoferrin and lysozyme, either singly or in combination, using an in vitro assay system. The two species exhibited significant interspecies differences in susceptibility to lactoferrin (p < 0.05), but not for lysozyme. C. krusei being more sensitive to lactoferrin (c 1.4 times) than C. albicans. Both species revealed significant intraspecies differences in their susceptibility to lysozyme (p < 0.05), but not for lactoferrin. No synergistic antifungal activity of the two proteins on either Candida species was noted. The results imply that the variable expression of the fungicidal activity of lactoferrin and lysozyme on Candida species may modulate the oral carriage of yeasts in a complex manner.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMISen_HK
dc.relation.ispartofAPMISen_HK
dc.subject.meshAntifungal Agents - pharmacologyen_HK
dc.subject.meshApoproteins - pharmacologyen_HK
dc.subject.meshCandida - drug effectsen_HK
dc.subject.meshCandida albicans - drug effectsen_HK
dc.subject.meshCandidiasis - drug therapyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLactoferrin - pharmacologyen_HK
dc.subject.meshMouth Mucosa - microbiologyen_HK
dc.subject.meshMuramidase - pharmacologyen_HK
dc.subject.meshRegression Analysisen_HK
dc.titleThe antifungal effect of lactoferrin and lysozyme on Candida krusei and Candida albicansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-4641&volume=105&spage=875&epage=883&date=1997&atitle=The+antifungal+effect+of+lactoferrin+and+lysozyme+on+Candida+krusei+and+Candida+albicansen_HK
dc.identifier.emailSamaranayake, YH:hema@hkucc.hku.hken_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, YH=rp00025en_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9393559-
dc.identifier.scopuseid_2-s2.0-0030730493en_HK
dc.identifier.hkuros28735en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030730493&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume105en_HK
dc.identifier.issue11en_HK
dc.identifier.spage875en_HK
dc.identifier.epage883en_HK
dc.identifier.isiWOS:A1997YE73300009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSamaranayake, YH=6602677237en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridWu, PC=7403119323en_HK
dc.identifier.scopusauthoridSo, M=36719004800en_HK

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