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Article: Pre-emptive ibuprofen arginate in third molar surgery: A double-blind randomized controlled crossover clinical trial

TitlePre-emptive ibuprofen arginate in third molar surgery: A double-blind randomized controlled crossover clinical trial
Authors
KeywordsIbuprofen arginate
Pre-emptive
Third molars
Issue Date2009
PublisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0045-0421
Citation
Australian Dental Journal, 2009, v. 54 n. 4, p. 355-360 How to Cite?
AbstractBackground: This study evaluated the effectiveness of 400 mg ibuprofen arginate either as a pre-emptive (PRE group) or postoperative (POST group) analgesic using a common dental pain model. Methods: A randomized double-blind crossover clinical trial involving a series of consecutive patients admitted for bilateral third molar surgery. Results were analysed according to the self-reported pain score and the pattern of rescue medication taken. Results: The mean pain score ranged from 0.73 to 1.60 for the PRE group and 0.47 to 1.41 for the POST group among 30 included subjects. The mean time point when first rescue medication taken was 7.3 hours and 8.3 hours postoperative, respectively. Nine patients (30 per cent) in the PRE group and 12 patients (40 per cent) in the POST group took no rescue medication. There was no statistically significant difference for all parameters between groups, while a majority (53 per cent) found the drug "good" to "excellent" in both groups. Conclusions: Ibuprofen arginate may be considered effective in reducing surgically induced moderate to severe pain when administered either pre-operatively or postoperatively due to the reported relatively low pain score, less consumption of rescue medication, delayed onset of pain, good number of pain-free patients and a high rating in the global assessment score. © 2009 Australian Dental Association.
Persistent Identifierhttp://hdl.handle.net/10722/66774
ISSN
2015 Impact Factor: 1.272
2015 SCImago Journal Rankings: 0.482
ISI Accession Number ID
Funding AgencyGrant Number
Zambon (HK)
Funding Information:

Thanks to Zambon (HK) for financial support for this clinical trail.

References

 

DC FieldValueLanguage
dc.contributor.authorLau, SLen_HK
dc.contributor.authorChow, RLKen_HK
dc.contributor.authorYeung, RWKen_HK
dc.contributor.authorSamman, Nen_HK
dc.date.accessioned2010-09-06T05:49:14Z-
dc.date.available2010-09-06T05:49:14Z-
dc.date.issued2009en_HK
dc.identifier.citationAustralian Dental Journal, 2009, v. 54 n. 4, p. 355-360en_HK
dc.identifier.issn0045-0421en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66774-
dc.description.abstractBackground: This study evaluated the effectiveness of 400 mg ibuprofen arginate either as a pre-emptive (PRE group) or postoperative (POST group) analgesic using a common dental pain model. Methods: A randomized double-blind crossover clinical trial involving a series of consecutive patients admitted for bilateral third molar surgery. Results were analysed according to the self-reported pain score and the pattern of rescue medication taken. Results: The mean pain score ranged from 0.73 to 1.60 for the PRE group and 0.47 to 1.41 for the POST group among 30 included subjects. The mean time point when first rescue medication taken was 7.3 hours and 8.3 hours postoperative, respectively. Nine patients (30 per cent) in the PRE group and 12 patients (40 per cent) in the POST group took no rescue medication. There was no statistically significant difference for all parameters between groups, while a majority (53 per cent) found the drug "good" to "excellent" in both groups. Conclusions: Ibuprofen arginate may be considered effective in reducing surgically induced moderate to severe pain when administered either pre-operatively or postoperatively due to the reported relatively low pain score, less consumption of rescue medication, delayed onset of pain, good number of pain-free patients and a high rating in the global assessment score. © 2009 Australian Dental Association.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=0045-0421en_HK
dc.relation.ispartofAustralian Dental Journalen_HK
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectIbuprofen arginateen_HK
dc.subjectPre-emptiveen_HK
dc.subjectThird molarsen_HK
dc.subject.meshAnalgesics, Non-Narcotic - administration and dosage-
dc.subject.meshArginine - administration and dosage-
dc.subject.meshMolar, Third - surgery-
dc.subject.meshPain, Postoperative - prevention and control-
dc.subject.meshTooth Extraction-
dc.titlePre-emptive ibuprofen arginate in third molar surgery: A double-blind randomized controlled crossover clinical trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0045-0421&volume=54&issue=4&spage=355&epage=360&date=2009&atitle=Pre-emptive+ibuprofen+arginate+in+third+molar+surgery:+a+double-blind+randomized+controlled+crossover+clinical+trialen_HK
dc.identifier.emailSamman, N:nsamman@hkucc.hku.hken_HK
dc.identifier.authoritySamman, N=rp00021en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1834-7819.2009.01162.xen_HK
dc.identifier.pmid20415935-
dc.identifier.scopuseid_2-s2.0-77949371604en_HK
dc.identifier.hkuros168482en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77949371604&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume54en_HK
dc.identifier.issue4en_HK
dc.identifier.spage355en_HK
dc.identifier.epage360en_HK
dc.identifier.eissn1834-7819-
dc.identifier.isiWOS:000272160600012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLau, SL=36600672300en_HK
dc.identifier.scopusauthoridChow, RLK=14621379900en_HK
dc.identifier.scopusauthoridYeung, RWK=7102833345en_HK
dc.identifier.scopusauthoridSamman, N=7006413627en_HK

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