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Article: Impact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazole

TitleImpact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazole
Authors
Issue Date2002
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
Citation
Oral Diseases, 2002, v. 8 n. 4, p. 199-206 How to Cite?
AbstractOBJECTIVE: To assess the antifungal activity of lysozyme and lactoferrin on 10 oral isolates each of Candida albicans and Candida tropicalis following their brief exposure (1 h) to subtherapeutic concentrations of two polyene drugs - nystatin, amphotericin B, and an azole -fluconazole. METHODS: Yeasts were sequentially exposed to sub-therapeutic concentrations of antifungals and then to either lysozyme or lactoferrin and the viability evaluated by quantifying colony-forming units. RESULTS: The exposure of both C. albicans and C. tropicalis isolates to all three antifungal agents significantly increased their susceptibility to lysozyme (P < 0.05) but not to lactoferrin. Exposure to the two polyene drugs had a lesser impact on the lysozyme susceptibility of both Candida species compared with the azole drug. Both interspecies and intraspecies sensitivity to lysozyme was noted and C. albicans was less susceptible than C. tropicalis. CONCLUSIONS: Lysozyme, in addition to being a potent natural antifungal agent, may act synergistically with the studied antimycotics.
Persistent Identifierhttp://hdl.handle.net/10722/66763
ISSN
2015 Impact Factor: 2.0
2015 SCImago Journal Rankings: 0.828
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnil, Sen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:49:08Z-
dc.date.available2010-09-06T05:49:08Z-
dc.date.issued2002en_HK
dc.identifier.citationOral Diseases, 2002, v. 8 n. 4, p. 199-206en_HK
dc.identifier.issn1354-523Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/66763-
dc.description.abstractOBJECTIVE: To assess the antifungal activity of lysozyme and lactoferrin on 10 oral isolates each of Candida albicans and Candida tropicalis following their brief exposure (1 h) to subtherapeutic concentrations of two polyene drugs - nystatin, amphotericin B, and an azole -fluconazole. METHODS: Yeasts were sequentially exposed to sub-therapeutic concentrations of antifungals and then to either lysozyme or lactoferrin and the viability evaluated by quantifying colony-forming units. RESULTS: The exposure of both C. albicans and C. tropicalis isolates to all three antifungal agents significantly increased their susceptibility to lysozyme (P < 0.05) but not to lactoferrin. Exposure to the two polyene drugs had a lesser impact on the lysozyme susceptibility of both Candida species compared with the azole drug. Both interspecies and intraspecies sensitivity to lysozyme was noted and C. albicans was less susceptible than C. tropicalis. CONCLUSIONS: Lysozyme, in addition to being a potent natural antifungal agent, may act synergistically with the studied antimycotics.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1en_HK
dc.relation.ispartofOral Diseasesen_HK
dc.subject.meshAmphotericin B - administration & dosage - therapeutic useen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnti-Infective Agents - therapeutic useen_HK
dc.subject.meshAntifungal Agents - administration & dosage - therapeutic useen_HK
dc.subject.meshCandida albicans - drug effectsen_HK
dc.subject.meshCandida tropicalis - drug effectsen_HK
dc.subject.meshColony Count, Microbialen_HK
dc.subject.meshFluconazole - administration & dosage - therapeutic useen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLactoferrin - therapeutic useen_HK
dc.subject.meshMicrobial Sensitivity Testsen_HK
dc.subject.meshMouth - microbiologyen_HK
dc.subject.meshMuramidase - therapeutic useen_HK
dc.subject.meshNystatin - administration & dosage - therapeutic useen_HK
dc.subject.meshSpecies Specificityen_HK
dc.subject.meshStatistics as Topicen_HK
dc.titleImpact of lysozyme and lactoferrin on oral Candida isolates exposed to polyene antimycotics and fluconazoleen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1354-523X&volume=8&spage=199&epage=206&date=2002&atitle=Impact+of+lysozyme+and+lactoferrin+on+oral+Candida+isolates+exposed+to+polyene+antimycotics+and+fluconazoleen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1601-0825.2002.01818.xen_HK
dc.identifier.pmid12206401-
dc.identifier.scopuseid_2-s2.0-0036021296en_HK
dc.identifier.hkuros67455en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036021296&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue4en_HK
dc.identifier.spage199en_HK
dc.identifier.epage206en_HK
dc.identifier.isiWOS:000176662500005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAnil, S=7006640037en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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