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Article: Candida glabrata, an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with Candida albicans

TitleCandida glabrata, an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with Candida albicans
Authors
Issue Date2002
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMIS
Citation
Apmis, 2002, v. 110 n. 9, p. 601-610 How to Cite?
AbstractOral candidosis is a common opportunistic infection in debilitated individuals and Candida glabrata is the second most frequently isolated species from this condition, after Candida albicans. Candidal adherence to various biological or non-biological surfaces is considered a prerequisite for colonization, and pathogenesis of candidal infections, and their relative cell surface hydrophobicity (CSH) is likely to be a possible contributory force involved in this process. Whereas a large body of data on the latter features of C. albicans is available, there is surprisingly little information on C. glabrata. As a comprehensive database on the relative adhesion and CSH of Candida spp. is instructive and useful, we investigated in vitro the latter attributes of 34 oral isolates of C. glabrata and 15 isolates of C. albicans. There were remarkable intraspecies differences in both the CSH and the adhesive ability of C. glabrata strains (p<0.001). Compared with C. albicans, C. glabrata demonstrated a four-fold greater CSH value (30.63±11.20% vs 7.23±3.56%, p<0.0001) and a two-fold greater tendency to adhere to denture acrylic surfaces (75.18±39.96 vs 30.36±9.21, p<0.0001). A significant positive correlation between CSH and adhesion was also noted for both C. glabrata (r=0.674, p<0.0001) and C. albicans (r=0.636, p<0.05). When the effect of different incubation conditions on the relative CSH and adherence of C. glabrata was examined, CSH and the adherence to acrylic surfaces of four of six C. glabrata isolates were significantly affected by a reduction of the culture temperature (from 37°C to 25°C). A positive relationship also emerged when the temperature-induced variations in the adherence values were correlated with their relative CSH. These data provide hitherto unavailable archival information on important pathogenic attributes of the two most common oral Candida species that may help explain their predominance in this milieu.
Persistent Identifierhttp://hdl.handle.net/10722/66751
ISSN
2015 Impact Factor: 1.933
2015 SCImago Journal Rankings: 0.855
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLuo, Gen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:49:02Z-
dc.date.available2010-09-06T05:49:02Z-
dc.date.issued2002en_HK
dc.identifier.citationApmis, 2002, v. 110 n. 9, p. 601-610en_HK
dc.identifier.issn0903-4641en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66751-
dc.description.abstractOral candidosis is a common opportunistic infection in debilitated individuals and Candida glabrata is the second most frequently isolated species from this condition, after Candida albicans. Candidal adherence to various biological or non-biological surfaces is considered a prerequisite for colonization, and pathogenesis of candidal infections, and their relative cell surface hydrophobicity (CSH) is likely to be a possible contributory force involved in this process. Whereas a large body of data on the latter features of C. albicans is available, there is surprisingly little information on C. glabrata. As a comprehensive database on the relative adhesion and CSH of Candida spp. is instructive and useful, we investigated in vitro the latter attributes of 34 oral isolates of C. glabrata and 15 isolates of C. albicans. There were remarkable intraspecies differences in both the CSH and the adhesive ability of C. glabrata strains (p<0.001). Compared with C. albicans, C. glabrata demonstrated a four-fold greater CSH value (30.63±11.20% vs 7.23±3.56%, p<0.0001) and a two-fold greater tendency to adhere to denture acrylic surfaces (75.18±39.96 vs 30.36±9.21, p<0.0001). A significant positive correlation between CSH and adhesion was also noted for both C. glabrata (r=0.674, p<0.0001) and C. albicans (r=0.636, p<0.05). When the effect of different incubation conditions on the relative CSH and adherence of C. glabrata was examined, CSH and the adherence to acrylic surfaces of four of six C. glabrata isolates were significantly affected by a reduction of the culture temperature (from 37°C to 25°C). A positive relationship also emerged when the temperature-induced variations in the adherence values were correlated with their relative CSH. These data provide hitherto unavailable archival information on important pathogenic attributes of the two most common oral Candida species that may help explain their predominance in this milieu.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APMISen_HK
dc.relation.ispartofAPMISen_HK
dc.subject.meshAcrylic Resins - chemistryen_HK
dc.subject.meshCandida albicans - chemistry - isolation & purification - physiologyen_HK
dc.subject.meshCandida glabrata - chemistry - isolation & purification - physiologyen_HK
dc.subject.meshCell Adhesionen_HK
dc.subject.meshCell Membrane - chemistryen_HK
dc.subject.meshDenturesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydrophobic and Hydrophilic Interactionsen_HK
dc.subject.meshPhotomicrographyen_HK
dc.subject.meshTemperatureen_HK
dc.titleCandida glabrata, an emerging fungal pathogen, exhibits superior relative cell surface hydrophobicity and adhesion to denture acrylic surfaces compared with Candida albicansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0903-4641&volume=110&spage=601&epage=10&date=2002&atitle=Candida+glabrata,+an+emerging+fungal+pathogen,+exhibits+superior+relative+cell+surface+hydrophobicity+and+adhesion+to+denture+acrylic+surfaces+compared+with+Candida+albicansen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1600-0463.2002.1100902.xen_HK
dc.identifier.pmid12529012-
dc.identifier.scopuseid_2-s2.0-0036756703en_HK
dc.identifier.hkuros75031en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036756703&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume110en_HK
dc.identifier.issue9en_HK
dc.identifier.spage601en_HK
dc.identifier.epage610en_HK
dc.identifier.isiWOS:000179205400002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLuo, G=55112399700en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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