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Article: Composite autogenous bone and demineralized bone matrices used to repair defects in the parietal bone of rabbits

TitleComposite autogenous bone and demineralized bone matrices used to repair defects in the parietal bone of rabbits
Authors
Issue Date2000
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjom
Citation
British Journal Of Oral And Maxillofacial Surgery, 2000, v. 38 n. 5, p. 565-570 How to Cite?
AbstractWe compared the amount of new bone produced by endochondral and intramembranous autogenous bone grafts in the presence of demineralized bone matrices (DBMs) prepared from intramembranous bone (DBM(IM)) or endochondral bone (DBM(EC)). Thirty-five bone defects were created in the parietal bone of 20 New Zealand White rabbits. In the experimental groups, 5 defects were grafted with endochondral bone, 5 with endochondral bone mixed with DBM(IM)) (EC-DBM(IM)), 5 with intramembranous bone mixed with DBM(IM) (IM-DBM(IM)) and 6 with endochondral bone mixed with DBM(EC) (EC-DBM(EC)). In the control groups, 10 defects were left alone (passive control) and 4 were grafted with rabbit skin collagen (active control). They were all killed on day 14 and the defects were prepared for histological study. Serial sections were cut across the whole defect. Quantitative analyses were made on 202 sections of the experimental groups by image analysis. A total of 414%, 708%, and 85% more new bone was formed in defects grafted with composite EC-DBM(IM), IM-DBM(IM) and EC-DBM(EC), respectively, than those grafted with endochondral bone alone (P<0.001). No bone was formed in either passive or active controls. In conclusion, demineralized bone matrices, particularly those derived from intramembranous bone, have extremely high osteoinductive properties and greatly improve the integration of autogenous bone grafts in the skull. (C) 2000 The British Association of Oral and Maxillofacial Surgeons.
Persistent Identifierhttp://hdl.handle.net/10722/66696
ISSN
2015 Impact Factor: 1.237
2015 SCImago Journal Rankings: 0.887
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2010-09-06T05:48:33Z-
dc.date.available2010-09-06T05:48:33Z-
dc.date.issued2000en_HK
dc.identifier.citationBritish Journal Of Oral And Maxillofacial Surgery, 2000, v. 38 n. 5, p. 565-570en_HK
dc.identifier.issn0266-4356en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66696-
dc.description.abstractWe compared the amount of new bone produced by endochondral and intramembranous autogenous bone grafts in the presence of demineralized bone matrices (DBMs) prepared from intramembranous bone (DBM(IM)) or endochondral bone (DBM(EC)). Thirty-five bone defects were created in the parietal bone of 20 New Zealand White rabbits. In the experimental groups, 5 defects were grafted with endochondral bone, 5 with endochondral bone mixed with DBM(IM)) (EC-DBM(IM)), 5 with intramembranous bone mixed with DBM(IM) (IM-DBM(IM)) and 6 with endochondral bone mixed with DBM(EC) (EC-DBM(EC)). In the control groups, 10 defects were left alone (passive control) and 4 were grafted with rabbit skin collagen (active control). They were all killed on day 14 and the defects were prepared for histological study. Serial sections were cut across the whole defect. Quantitative analyses were made on 202 sections of the experimental groups by image analysis. A total of 414%, 708%, and 85% more new bone was formed in defects grafted with composite EC-DBM(IM), IM-DBM(IM) and EC-DBM(EC), respectively, than those grafted with endochondral bone alone (P<0.001). No bone was formed in either passive or active controls. In conclusion, demineralized bone matrices, particularly those derived from intramembranous bone, have extremely high osteoinductive properties and greatly improve the integration of autogenous bone grafts in the skull. (C) 2000 The British Association of Oral and Maxillofacial Surgeons.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/bjomen_HK
dc.relation.ispartofBritish Journal of Oral and Maxillofacial Surgeryen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBone Demineralization Techniqueen_HK
dc.subject.meshBone Matrix - transplantationen_HK
dc.subject.meshBone Regenerationen_HK
dc.subject.meshBone Transplantation - methods - pathology - statistics & numerical dataen_HK
dc.subject.meshCollagen - isolation & purification - therapeutic useen_HK
dc.subject.meshParietal Bone - surgeryen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshTransplantation, Autologousen_HK
dc.titleComposite autogenous bone and demineralized bone matrices used to repair defects in the parietal bone of rabbitsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0266-4356&volume=38&issue=5&spage=565&epage=570&date=2000&atitle=Composite+autogenous+bone+and+demineralized+bone+matrices+used+to+repair+defects+in+the+parietal+bone+of+rabbitsen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1054/bjom.2000.0464en_HK
dc.identifier.pmid11010797-
dc.identifier.scopuseid_2-s2.0-0033785137en_HK
dc.identifier.hkuros56007en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033785137&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue5en_HK
dc.identifier.spage565en_HK
dc.identifier.epage570en_HK
dc.identifier.isiWOS:000089952300032-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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