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Article: Comparison of gene expression of osteogenic factors between continuous and intermittent distraction osteogenesis in rabbit mandibular lengthening

TitleComparison of gene expression of osteogenic factors between continuous and intermittent distraction osteogenesis in rabbit mandibular lengthening
Authors
Issue Date2009
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleo
Citation
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2009, v. 108 n. 4, p. 496-499 How to Cite?
AbstractObjectives: This study aimed to evaluate the effect of distraction frequency on the gene expression of osteogenic mediators in mandibular distraction osteogenesis. Study design: Forty adult New Zealand white rabbits were randomly assigned to the continuous and intermittent distraction groups. Unilateral mandibular osteotomy was performed and custom-designed manual-driven or autodriven distractor was bridged over the osteotomy segments. Animals were humanely killed at day 6, day 10, day 14, and day 21 after osteotomy. mRNA expression of the osteogenic mediators in the distraction regenerate was examined by real-time polymerase chain reaction. Results: The expression of transforming growth factor-β1 was significantly higher at day 6, and the expression of the bone morphogenetic protein-2 was significantly higher from day 6 to day 14, in the continuous distraction group. Conclusion: High-frequency traction up-regulates the expression of osteogenic mediators contributing to the enhanced bone formation. © 2009 Mosby, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66693
ISSN
2011 Impact Factor: 1.457
ISI Accession Number ID
Funding AgencyGrant Number
AO foundationS-07-14Z
Funding Information:

Project no. S-07-14Z was supported by the AO Research Fund of the AO foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorZheng, LWen_HK
dc.contributor.authorMa, Len_HK
dc.contributor.authorCheung, LKen_HK
dc.date.accessioned2010-09-06T05:48:32Z-
dc.date.available2010-09-06T05:48:32Z-
dc.date.issued2009en_HK
dc.identifier.citationOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology And Endodontology, 2009, v. 108 n. 4, p. 496-499en_HK
dc.identifier.issn1079-2104en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66693-
dc.description.abstractObjectives: This study aimed to evaluate the effect of distraction frequency on the gene expression of osteogenic mediators in mandibular distraction osteogenesis. Study design: Forty adult New Zealand white rabbits were randomly assigned to the continuous and intermittent distraction groups. Unilateral mandibular osteotomy was performed and custom-designed manual-driven or autodriven distractor was bridged over the osteotomy segments. Animals were humanely killed at day 6, day 10, day 14, and day 21 after osteotomy. mRNA expression of the osteogenic mediators in the distraction regenerate was examined by real-time polymerase chain reaction. Results: The expression of transforming growth factor-β1 was significantly higher at day 6, and the expression of the bone morphogenetic protein-2 was significantly higher from day 6 to day 14, in the continuous distraction group. Conclusion: High-frequency traction up-regulates the expression of osteogenic mediators contributing to the enhanced bone formation. © 2009 Mosby, Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/tripleoen_HK
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontologyen_HK
dc.subject.meshBone Morphogenetic Protein 2 - analysis-
dc.subject.meshMandible - surgery-
dc.subject.meshOsteogenesis - genetics-
dc.subject.meshOsteogenesis, Distraction - instrumentation - methods-
dc.subject.meshTransforming Growth Factor beta1 - analysis-
dc.titleComparison of gene expression of osteogenic factors between continuous and intermittent distraction osteogenesis in rabbit mandibular lengtheningen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1079-2104&volume=108&issue=4&spage=496&epage=499&date=2009&atitle=Comparison+of+gene+expression+of+osteogenic+factors+between+continuous+and+intermittent+distraction+osteogenesis+in+rabbit+mandibular+lengtheningen_HK
dc.identifier.emailZheng, LW:lwzheng@hku.hken_HK
dc.identifier.emailCheung, LK:lkcheung@hkucc.hku.hken_HK
dc.identifier.authorityZheng, LW=rp01411en_HK
dc.identifier.authorityCheung, LK=rp00013en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.tripleo.2009.05.038en_HK
dc.identifier.pmid19716721-
dc.identifier.scopuseid_2-s2.0-70349183230en_HK
dc.identifier.hkuros167657en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349183230&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume108en_HK
dc.identifier.issue4en_HK
dc.identifier.spage496en_HK
dc.identifier.epage499en_HK
dc.identifier.isiWOS:000270084800006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZheng, LW=11241247300en_HK
dc.identifier.scopusauthoridMa, L=36071946000en_HK
dc.identifier.scopusauthoridCheung, LK=7102302747en_HK

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