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Article: Factors regulating mandibular condylar growth

TitleFactors regulating mandibular condylar growth
Authors
Issue Date2002
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
Citation
American Journal Of Orthodontics And Dentofacial Orthopedics, 2002, v. 122 n. 4, p. 401-409 How to Cite?
AbstractFactors regulating condylar growth have not been identified before. This study was designed to identify a series of these factors, such as Sox 9 transcription factor and vascular endothelial growth factor (VEGF), and also to correlate the amount of type X collagen expressed during natural growth to the amount of bone newly formed. We used 115 Sprague-Dawley rats, 35 days old, in this study. The expression of these factors was identified on protein level by using immunostaining. Type X collagen was identified on mRNA and protein levels. Sox 9 was expressed by cells in the proliferative layer and by chondrocytes. Type X was expressed only by hypertrophic chondrocytes, and its expression precedes the onset of endochondral ossification. VEGF is expressed by hypertrophic chondrocytes, and its maximum level of expression precedes the maximum level of bone formation. Condylar growth involves a sequence of transitory stages uniquely defined by molecules that are intrinsically synthesized by cells in the condyles. Copyright © 2002 by the American Association of Orthodontists.
Persistent Identifierhttp://hdl.handle.net/10722/66686
ISSN
2015 Impact Factor: 1.69
2015 SCImago Journal Rankings: 1.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2010-09-06T05:48:28Z-
dc.date.available2010-09-06T05:48:28Z-
dc.date.issued2002en_HK
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2002, v. 122 n. 4, p. 401-409en_HK
dc.identifier.issn0889-5406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66686-
dc.description.abstractFactors regulating condylar growth have not been identified before. This study was designed to identify a series of these factors, such as Sox 9 transcription factor and vascular endothelial growth factor (VEGF), and also to correlate the amount of type X collagen expressed during natural growth to the amount of bone newly formed. We used 115 Sprague-Dawley rats, 35 days old, in this study. The expression of these factors was identified on protein level by using immunostaining. Type X collagen was identified on mRNA and protein levels. Sox 9 was expressed by cells in the proliferative layer and by chondrocytes. Type X was expressed only by hypertrophic chondrocytes, and its expression precedes the onset of endochondral ossification. VEGF is expressed by hypertrophic chondrocytes, and its maximum level of expression precedes the maximum level of bone formation. Condylar growth involves a sequence of transitory stages uniquely defined by molecules that are intrinsically synthesized by cells in the condyles. Copyright © 2002 by the American Association of Orthodontists.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodoen_HK
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_HK
dc.rightsAmerican Journal of Orthodontics and Dentofacial Orthopedics. Copyright © Mosby, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshChondrocytes - metabolismen_HK
dc.subject.meshChondrogenesisen_HK
dc.subject.meshCollagen Type II - biosynthesisen_HK
dc.subject.meshCollagen Type X - biosynthesisen_HK
dc.subject.meshEndothelial Growth Factors - biosynthesisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Expression Regulation, Developmentalen_HK
dc.subject.meshHigh Mobility Group Proteins - biosynthesisen_HK
dc.subject.meshImmunoenzyme Techniquesen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshIntercellular Signaling Peptides and Proteins - biosynthesisen_HK
dc.subject.meshLymphokines - biosynthesisen_HK
dc.subject.meshMandibular Condyle - blood supply - cytology - growth & development - metabolismen_HK
dc.subject.meshOsteogenesisen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshSOX9 Transcription Factoren_HK
dc.subject.meshTranscription Factors - biosynthesisen_HK
dc.subject.meshVascular Endothelial Growth Factor Aen_HK
dc.subject.meshVascular Endothelial Growth Factorsen_HK
dc.titleFactors regulating mandibular condylar growthen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-5406&volume=122&spage=401&epage=409&date=2002&atitle=Factors+regulating+mandibular+condylar+growthen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1067/mod.2002.125713en_HK
dc.identifier.pmid12411886-
dc.identifier.scopuseid_2-s2.0-0036781134en_HK
dc.identifier.hkuros76137en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036781134&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume122en_HK
dc.identifier.issue4en_HK
dc.identifier.spage401en_HK
dc.identifier.epage409en_HK
dc.identifier.isiWOS:000179148800013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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