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Article: The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats

TitleThe effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats
Authors
Issue Date2009
PublisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed
Citation
Phytomedicine, 2009, v. 16 n. 9, p. 830-838 How to Cite?
AbstractThe purpose of this study was to investigate the effects of Rhodiola rosea extract and depression on the serotonin (5-HT) level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats induced by Chronic Mild Stress (CMS). Seventy male Sprague-Dawley rats were divided into seven groups (10 per group): normal control group, untreated depressive rat model group, negative control group, positive control group, low dosage Rhodiola rosea extract (1.5 g/kg) group, medium dosage Rhodiola rosea extract (3 g/kg) group and high dosage Rhodiola rosea extract (6 g/kg) group. After the depressive rats induced by CMS had received Rhodiola rosea extract for 3 weeks, the 5-HT levels at cerebral hippocampus were detected by high performance liquid chromatography. Bromodeoxyuridine (BrdU) was injected in vivo to label the proliferating cells at hippocampus, and morphometry was used to count the hippocampal neurons. The results showed that the 5-HT level of the three experimental groups had recovered to normal status. The immunohistochemistry of hippocampus BrdU positive cells had returned to the normal level in the group of depressive rats with low dosage Rhodiola rosea extract. In conclusion the results demonstrated that Rhodiola rosea extract could improve 5-HT level in hippocampus in depressive rats, and low dosage Rhodiola rosea could induce neural stem cell proliferation at hippocampus to return to normal level, repairing the injured neurons at hippocampus. © 2009 Elsevier GmbH. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66666
ISSN
2015 Impact Factor: 2.937
2015 SCImago Journal Rankings: 1.013
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, QGen_HK
dc.contributor.authorZeng, YSen_HK
dc.contributor.authorQu, ZQen_HK
dc.contributor.authorTang, JYen_HK
dc.contributor.authorQin, YJen_HK
dc.contributor.authorChung, Pen_HK
dc.contributor.authorWong, Ren_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2010-09-06T05:48:17Z-
dc.date.available2010-09-06T05:48:17Z-
dc.date.issued2009en_HK
dc.identifier.citationPhytomedicine, 2009, v. 16 n. 9, p. 830-838en_HK
dc.identifier.issn0944-7113en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66666-
dc.description.abstractThe purpose of this study was to investigate the effects of Rhodiola rosea extract and depression on the serotonin (5-HT) level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats induced by Chronic Mild Stress (CMS). Seventy male Sprague-Dawley rats were divided into seven groups (10 per group): normal control group, untreated depressive rat model group, negative control group, positive control group, low dosage Rhodiola rosea extract (1.5 g/kg) group, medium dosage Rhodiola rosea extract (3 g/kg) group and high dosage Rhodiola rosea extract (6 g/kg) group. After the depressive rats induced by CMS had received Rhodiola rosea extract for 3 weeks, the 5-HT levels at cerebral hippocampus were detected by high performance liquid chromatography. Bromodeoxyuridine (BrdU) was injected in vivo to label the proliferating cells at hippocampus, and morphometry was used to count the hippocampal neurons. The results showed that the 5-HT level of the three experimental groups had recovered to normal status. The immunohistochemistry of hippocampus BrdU positive cells had returned to the normal level in the group of depressive rats with low dosage Rhodiola rosea extract. In conclusion the results demonstrated that Rhodiola rosea extract could improve 5-HT level in hippocampus in depressive rats, and low dosage Rhodiola rosea could induce neural stem cell proliferation at hippocampus to return to normal level, repairing the injured neurons at hippocampus. © 2009 Elsevier GmbH. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherUrban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomeden_HK
dc.relation.ispartofPhytomedicineen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntidepressive Agents - administration & dosage - pharmacology - therapeutic useen_HK
dc.subject.meshCell Proliferation - drug effectsen_HK
dc.subject.meshDepression - drug therapy - metabolismen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshHippocampus - drug effects - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshNeurons - drug effectsen_HK
dc.subject.meshPhytotherapyen_HK
dc.subject.meshPlant Extracts - administration & dosage - pharmacology - therapeutic useen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshRhodiolaen_HK
dc.subject.meshSerotonin - metabolismen_HK
dc.titleThe effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive ratsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0944-7113&volume=16&spage=830&epage=838&date=2009&atitle=The+effects+of+Rhodiola+rosea+extract+on+5-HT+level,+cell+proliferation+and+quantity+of+neurons+at+cerebral+hippocampus+of+depressive+ratsen_HK
dc.identifier.emailHägg, U:euohagg@hkusua.hku.hken_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.phymed.2009.03.011en_HK
dc.identifier.pmid19403286-
dc.identifier.scopuseid_2-s2.0-67650527269en_HK
dc.identifier.hkuros161022en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650527269&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue9en_HK
dc.identifier.spage830en_HK
dc.identifier.epage838en_HK
dc.identifier.isiWOS:000269340800005-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridChen, QG=23983960100en_HK
dc.identifier.scopusauthoridZeng, YS=8236229300en_HK
dc.identifier.scopusauthoridQu, ZQ=14068003100en_HK
dc.identifier.scopusauthoridTang, JY=17344327800en_HK
dc.identifier.scopusauthoridQin, YJ=23986219000en_HK
dc.identifier.scopusauthoridChung, P=35204745900en_HK
dc.identifier.scopusauthoridWong, R=26029245400en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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