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Article: The impact of chlorhexidine gluconate on the relative cell surface hydrophobicity of oral Candida albicans

TitleThe impact of chlorhexidine gluconate on the relative cell surface hydrophobicity of oral Candida albicans
Authors
Issue Date2001
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1
Citation
Oral Diseases, 2001, v. 7 n. 2, p. 119-122 How to Cite?
AbstractAdherence of Candida albicans has been implicated as the first step in the pathogenesis of oral candidosis, and its relative cell surface hydrophobicity (CSH) a contributory physical force. Chlorhexidine gluconate is by far the commonest antiseptic mouthwash prescribed in dentistry. The intra-oral concentrations of the retained chlorhexldine mouthwash fluctuate considerably due to the dilution effect of saliva and the cleansing action of the oral musculature. Hence the objective of the present study was to investigate the effect of brief exposure to sub-therapeutic concentrations of chlorhexidine gluconate on the relative CSH of C. albicans. DESIGN: The CSH of the isolates was assessed by a biphasic aqueous-hydrocarbon assay. RESULTS: A statistically significant reduction in CSH was observed following the exposure of Candida isolates to 0.005 and 0.0025% chlorhexidine gluconate. CONCLUSIONS: These results elucidate additional mechanisms by which chlorhexidine gluconate suppress candidal pathogenicity despite a brief period of transient exposure within the oral environment.
Persistent Identifierhttp://hdl.handle.net/10722/66636
ISSN
2015 Impact Factor: 2.0
2015 SCImago Journal Rankings: 0.828
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnil, Sen_HK
dc.contributor.authorEllepola, ANBen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:48:02Z-
dc.date.available2010-09-06T05:48:02Z-
dc.date.issued2001en_HK
dc.identifier.citationOral Diseases, 2001, v. 7 n. 2, p. 119-122en_HK
dc.identifier.issn1354-523Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/66636-
dc.description.abstractAdherence of Candida albicans has been implicated as the first step in the pathogenesis of oral candidosis, and its relative cell surface hydrophobicity (CSH) a contributory physical force. Chlorhexidine gluconate is by far the commonest antiseptic mouthwash prescribed in dentistry. The intra-oral concentrations of the retained chlorhexldine mouthwash fluctuate considerably due to the dilution effect of saliva and the cleansing action of the oral musculature. Hence the objective of the present study was to investigate the effect of brief exposure to sub-therapeutic concentrations of chlorhexidine gluconate on the relative CSH of C. albicans. DESIGN: The CSH of the isolates was assessed by a biphasic aqueous-hydrocarbon assay. RESULTS: A statistically significant reduction in CSH was observed following the exposure of Candida isolates to 0.005 and 0.0025% chlorhexidine gluconate. CONCLUSIONS: These results elucidate additional mechanisms by which chlorhexidine gluconate suppress candidal pathogenicity despite a brief period of transient exposure within the oral environment.en_HK
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1en_HK
dc.relation.ispartofOral Diseasesen_HK
dc.subject.meshAdhesivenessen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAnti-Infective Agents, Local - administration & dosage - pharmacologyen_HK
dc.subject.meshCandida albicans - cytology - drug effectsen_HK
dc.subject.meshCell Membrane - drug effects - ultrastructureen_HK
dc.subject.meshChlorhexidine - administration & dosage - analogs & derivatives - pharmacologyen_HK
dc.subject.meshColony Count, Microbialen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydrocarbonsen_HK
dc.subject.meshMouth - microbiologyen_HK
dc.subject.meshWateren_HK
dc.subject.meshWettabilityen_HK
dc.titleThe impact of chlorhexidine gluconate on the relative cell surface hydrophobicity of oral Candida albicansen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1354-523X&volume=7&spage=118&epage=122&date=2001&atitle=The+impact+of+chlorhexidine+gluconate+on+the+relative+cell+surface+hydrophobicity+of+oral+Candida+albicansen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1034/j.1601-0825.2001.0070210.xen_HK
dc.identifier.pmid11355437-
dc.identifier.scopuseid_2-s2.0-0035052657en_HK
dc.identifier.hkuros56951en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035052657&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue2en_HK
dc.identifier.spage119en_HK
dc.identifier.epage122en_HK
dc.identifier.isiWOS:000168236800010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAnil, S=7006640037en_HK
dc.identifier.scopusauthoridEllepola, ANB=6604060863en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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