File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Temporal expression of SOX9 and type II collagen in spheno-occipital synchondrosis of mice after mechanical tension Stimuli

TitleTemporal expression of SOX9 and type II collagen in spheno-occipital synchondrosis of mice after mechanical tension Stimuli
Authors
KeywordsCartilage
SOX9
Spheno-occipital synchondrosis
Tensile stress
Type II collagen
Issue Date2008
PublisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/
Citation
Angle Orthodontist, 2008, v. 78 n. 1, p. 83-88 How to Cite?
AbstractObjective: To associate the expressions of SOX9 and type II collagen during growth in the synchondrosis with and without tensile stress in order to understand the role of these factors in the growth of cartilage in spheno-occipital synchondrosis. Materials and Methods: Sixty 1-day-old male BALB/c mice were randomly divided into experimental and control groups. Each group was subdivided again into five different time points which were 6, 24, 48, 72, and 168 hours. Each subgroup consisted of five mice. Each mouse was sacrificed using an overdose of pentobarbitone sodium. The synchondroses were aseptically removed and incubated in a 24-well plate with or without tensile stress in tissue culture. Tissue sections were stained immunohistochemically to quantitatively analyze the expression of SOX9 and type II collagen. Results: There was a statistically significant increase of 57% (P < .001) in the expression of SOX9 between the experimental and control groups at 24 hours, followed by a significant increase of 44.4% (P < .001) in the expression of type II collagen at 72 hours. Conclusions: SOX9 may play an important role for early differentiation of chondrocytes and increase the expression of type II collagen, a major component of the extracellular matrix, during the growth of cartilage in the spheno-occipital synchondrosis. © 2007 by The EH Angle Education and Research Foundation, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/66608
ISSN
2015 Impact Factor: 1.579
2015 SCImago Journal Rankings: 1.254
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCendekiawan, Ten_HK
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:47:48Z-
dc.date.available2010-09-06T05:47:48Z-
dc.date.issued2008en_HK
dc.identifier.citationAngle Orthodontist, 2008, v. 78 n. 1, p. 83-88en_HK
dc.identifier.issn0003-3219en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66608-
dc.description.abstractObjective: To associate the expressions of SOX9 and type II collagen during growth in the synchondrosis with and without tensile stress in order to understand the role of these factors in the growth of cartilage in spheno-occipital synchondrosis. Materials and Methods: Sixty 1-day-old male BALB/c mice were randomly divided into experimental and control groups. Each group was subdivided again into five different time points which were 6, 24, 48, 72, and 168 hours. Each subgroup consisted of five mice. Each mouse was sacrificed using an overdose of pentobarbitone sodium. The synchondroses were aseptically removed and incubated in a 24-well plate with or without tensile stress in tissue culture. Tissue sections were stained immunohistochemically to quantitatively analyze the expression of SOX9 and type II collagen. Results: There was a statistically significant increase of 57% (P < .001) in the expression of SOX9 between the experimental and control groups at 24 hours, followed by a significant increase of 44.4% (P < .001) in the expression of type II collagen at 72 hours. Conclusions: SOX9 may play an important role for early differentiation of chondrocytes and increase the expression of type II collagen, a major component of the extracellular matrix, during the growth of cartilage in the spheno-occipital synchondrosis. © 2007 by The EH Angle Education and Research Foundation, Inc.en_HK
dc.languageengen_HK
dc.publisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/en_HK
dc.relation.ispartofAngle Orthodontisten_HK
dc.subjectCartilageen_HK
dc.subjectSOX9en_HK
dc.subjectSpheno-occipital synchondrosisen_HK
dc.subjectTensile stressen_HK
dc.subjectType II collagenen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiation - physiologyen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshChondrocytes - physiologyen_HK
dc.subject.meshCollagen Type II - analysisen_HK
dc.subject.meshCulture Media, Serum-Freeen_HK
dc.subject.meshGrowth Plate - cytology - growth & developmenten_HK
dc.subject.meshHigh Mobility Group Proteins - analysisen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred BALB Cen_HK
dc.subject.meshOccipital Bone - cytology - growth & developmenten_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshSOX9 Transcription Factoren_HK
dc.subject.meshSphenoid Bone - cytology - growth & developmenten_HK
dc.subject.meshStress, Mechanicalen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTissue Culture Techniquesen_HK
dc.subject.meshTranscription Factors - analysisen_HK
dc.titleTemporal expression of SOX9 and type II collagen in spheno-occipital synchondrosis of mice after mechanical tension Stimulien_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-3219&volume=78 No 1&spage=83&epage=88&date=2007&atitle=Temporal+Expression+of+SOX9+and+Type+II+Collagen+in+Spheno-Occipital+Synchondrosis+of+Mice+after+Mechanical+Tension+Stimuli.+en_HK
dc.identifier.emailWong, RWK: fyoung@hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2319/012507-36.1en_HK
dc.identifier.pmid18193955-
dc.identifier.scopuseid_2-s2.0-38349042337en_HK
dc.identifier.hkuros133600en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38349042337&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume78en_HK
dc.identifier.issue1en_HK
dc.identifier.spage83en_HK
dc.identifier.epage88en_HK
dc.identifier.isiWOS:000252511100013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCendekiawan, T=23466398900en_HK
dc.identifier.scopusauthoridWong, RWK=7402127170en_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats