File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Article: Bone induction using hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors

TitleBone induction using hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
Authors
KeywordsBone morphogenetic proteins
Hydroxymethylglutaryl-CoA reductase inhibitors
Osteogenesis
Simvastatin/pharmacology
Issue Date2007
PublisherHong Kong Dental Association.
Citation
Hong Kong Dental Journal, 2007, v. 4, p. 15-21 How to Cite?
AbstractABSTRACT Objectives. The search of a non-toxic material to replace bone remains a big challenge for scientists. Previous studies examined more than 30 000 compounds from a collection of natural products and identified that statins, commonly used hydroxymethylglutaryl coenzyme A reductase inhibitors (HMGRIs), increased expression of the morphogenetic protein (BMP)-2 gene. This article summarizes our research into the use of HMGRIs to induce bone formation. Methods. Twenty-four bone defects from 12 New Zealand White rabbits were divided into four study groups (negative control, control, statin, and naringin) for quantitative assessment of new bone formation with HMGRIs, and 30 bone defects from another 15 New Zealand White rabbits divided into two groups (control and statin) for study of early healing pattern of HMGRI-induced osteogenesis. Results. Two hundred and ninety-eight percent and 490% more new bone were respectively formed by statin and naringin both mixed with a collagen carrier comparing with defects grafted with the carrier alone. Using immunolocalization studies to look into the mechanisms of the HMGRI-induced osteogenesis, it was shown that for early healing defects grafted with statin, the vascular endothelial growth factor, BMP-2, core-binding factor alpha 1 were expressed 1 day earlier than those grafted with the carrier alone. Conclusion. Statin and naringin in collagen matrix carriers had the effect of increasing new bone formation locally and may be useful as a bone graft material.
Persistent Identifierhttp://hdl.handle.net/10722/66580
ISSN

 

DC FieldValueLanguage
dc.contributor.authorWong, RWKen_HK
dc.contributor.authorRabie, ABMen_HK
dc.date.accessioned2010-09-06T05:47:33Z-
dc.date.available2010-09-06T05:47:33Z-
dc.date.issued2007en_HK
dc.identifier.citationHong Kong Dental Journal, 2007, v. 4, p. 15-21en_HK
dc.identifier.issn1727-2300en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66580-
dc.description.abstractABSTRACT Objectives. The search of a non-toxic material to replace bone remains a big challenge for scientists. Previous studies examined more than 30 000 compounds from a collection of natural products and identified that statins, commonly used hydroxymethylglutaryl coenzyme A reductase inhibitors (HMGRIs), increased expression of the morphogenetic protein (BMP)-2 gene. This article summarizes our research into the use of HMGRIs to induce bone formation. Methods. Twenty-four bone defects from 12 New Zealand White rabbits were divided into four study groups (negative control, control, statin, and naringin) for quantitative assessment of new bone formation with HMGRIs, and 30 bone defects from another 15 New Zealand White rabbits divided into two groups (control and statin) for study of early healing pattern of HMGRI-induced osteogenesis. Results. Two hundred and ninety-eight percent and 490% more new bone were respectively formed by statin and naringin both mixed with a collagen carrier comparing with defects grafted with the carrier alone. Using immunolocalization studies to look into the mechanisms of the HMGRI-induced osteogenesis, it was shown that for early healing defects grafted with statin, the vascular endothelial growth factor, BMP-2, core-binding factor alpha 1 were expressed 1 day earlier than those grafted with the carrier alone. Conclusion. Statin and naringin in collagen matrix carriers had the effect of increasing new bone formation locally and may be useful as a bone graft material.-
dc.languageengen_HK
dc.publisherHong Kong Dental Association.en_HK
dc.relation.ispartofHong Kong Dental Journalen_HK
dc.subjectBone morphogenetic proteins-
dc.subjectHydroxymethylglutaryl-CoA reductase inhibitors-
dc.subjectOsteogenesis-
dc.subjectSimvastatin/pharmacology-
dc.titleBone induction using hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitorsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1727-2300&volume=4&spage=15&epage=21&date=2007&atitle=Bone+Induction+using+HMG-CoA+reductase+inhibitors.en_HK
dc.identifier.emailWong, RWK: fyoung@hkucc.hku.hken_HK
dc.identifier.emailRabie, ABM: rabie@hkusua.hku.hken_HK
dc.identifier.authorityWong, RWK=rp00038en_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.hkuros153481en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats