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Article: Adhesion of oral Candida albicans isolates to denture acrylic following limited exposure to antifungal agents

TitleAdhesion of oral Candida albicans isolates to denture acrylic following limited exposure to antifungal agents
Authors
Issue Date1998
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 1998, v. 43 n. 12, p. 999-1007 How to Cite?
AbstractCandidal adherence to denture acrylic surfaces is implicated as the first step in the pathogenesis of Candida-associated denture stomatitis, the most prevalent form of oral candidosis in the West. This condition is treated by topically administered antifungal agents, mainly belonging to the polyenes and azoles. As the intraoral concentrations of antifungals fluctuate considerably due to the dynamics of the oral environment, the effect of short exposure to sublethal concentrations of antifungals on the adhesion of Candida albicans to denture acrylic surfaces was investigated. Seven oral C. albicans isolates were exposed to four-eight times minimum inhibitory concentrations (MIC) of five antifungal drugs, nystatin, amphotericin B, 5- fluorocytosine, ketoconazole and fluconazole, for 1 h. After removing the drug (by repeated washing) the adhesion of these isolates to acrylic strips was assessed by an in vitro adhesion assay. Exposure to antifungal agents significantly reduced the adherence of all seven C. albicans isolates to denture acrylic. The mean percentage reductions of adhesion after limited exposure to nystatin, amphotericin B, 5-fluorocytosine, ketoconazole and fluconazole were 86.48, 90.85, 66.72, 65.88 and 47.42%, respectively. These findings indicate that subtherapeutic doses of antifungals may modulate oral candidal colonization. Further, these results may have an important bearing on dosage regimens currently employed in treating oral candidosis.
Persistent Identifierhttp://hdl.handle.net/10722/66570
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorEllepola, ANBen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.date.accessioned2010-09-06T05:47:28Z-
dc.date.available2010-09-06T05:47:28Z-
dc.date.issued1998en_HK
dc.identifier.citationArchives Of Oral Biology, 1998, v. 43 n. 12, p. 999-1007en_HK
dc.identifier.issn0003-9969en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66570-
dc.description.abstractCandidal adherence to denture acrylic surfaces is implicated as the first step in the pathogenesis of Candida-associated denture stomatitis, the most prevalent form of oral candidosis in the West. This condition is treated by topically administered antifungal agents, mainly belonging to the polyenes and azoles. As the intraoral concentrations of antifungals fluctuate considerably due to the dynamics of the oral environment, the effect of short exposure to sublethal concentrations of antifungals on the adhesion of Candida albicans to denture acrylic surfaces was investigated. Seven oral C. albicans isolates were exposed to four-eight times minimum inhibitory concentrations (MIC) of five antifungal drugs, nystatin, amphotericin B, 5- fluorocytosine, ketoconazole and fluconazole, for 1 h. After removing the drug (by repeated washing) the adhesion of these isolates to acrylic strips was assessed by an in vitro adhesion assay. Exposure to antifungal agents significantly reduced the adherence of all seven C. albicans isolates to denture acrylic. The mean percentage reductions of adhesion after limited exposure to nystatin, amphotericin B, 5-fluorocytosine, ketoconazole and fluconazole were 86.48, 90.85, 66.72, 65.88 and 47.42%, respectively. These findings indicate that subtherapeutic doses of antifungals may modulate oral candidal colonization. Further, these results may have an important bearing on dosage regimens currently employed in treating oral candidosis.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_HK
dc.relation.ispartofArchives of Oral Biologyen_HK
dc.subject.meshAdhesivenessen_HK
dc.subject.meshAdministration, Topicalen_HK
dc.subject.meshAmphotericin B - administration & dosage - pharmacologyen_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshAntifungal Agents - administration & dosage - pharmacologyen_HK
dc.subject.meshCandida albicans - classification - drug effects - ultrastructureen_HK
dc.subject.meshCandidiasis, Oral - drug therapyen_HK
dc.subject.meshDenture Basesen_HK
dc.subject.meshDrug Administration Scheduleen_HK
dc.subject.meshFluconazole - administration & dosage - pharmacologyen_HK
dc.subject.meshFlucytosine - administration & dosage - pharmacologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshKetoconazole - administration & dosage - pharmacologyen_HK
dc.subject.meshMouth - microbiologyen_HK
dc.subject.meshNystatin - administration & dosage - pharmacologyen_HK
dc.subject.meshPolymethyl Methacrylate - chemistryen_HK
dc.subject.meshStomatitis, Denture - drug therapy - microbiologyen_HK
dc.subject.meshSurface Propertiesen_HK
dc.subject.meshTime Factorsen_HK
dc.titleAdhesion of oral Candida albicans isolates to denture acrylic following limited exposure to antifungal agentsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9969&volume=43&spage=999&epage=1007&date=1999&atitle=Adhesion+of+oral+Candida+albicans+isolates+to+denture+acrylic+following+limited+exposure+to+antifungal+agentsen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0003-9969(98)00075-2en_HK
dc.identifier.pmid9877331-
dc.identifier.scopuseid_2-s2.0-0032403185en_HK
dc.identifier.hkuros39499en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032403185&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume43en_HK
dc.identifier.issue12en_HK
dc.identifier.spage999en_HK
dc.identifier.epage1007en_HK
dc.identifier.isiWOS:000077551100010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridEllepola, ANB=6604060863en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK

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