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Article: Correlation of replicating cells and osteogenesis in the glenoid fossa during stepwise advancement

TitleCorrelation of replicating cells and osteogenesis in the glenoid fossa during stepwise advancement
Authors
Issue Date2003
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodo
Citation
American Journal Of Orthodontics And Dentofacial Orthopedics, 2003, v. 123 n. 5, p. 521-526 How to Cite?
AbstractThe purposes of this study were to quantify the number of replicating mesenchymal cells and to correlate it with the amount of new bone formed in the glenoid fossa during stepwise advancement. We randomly divided 250 female Sprague-Dawley rats, 35 days old, into 10 control groups (n = 5) and 20 experimental groups (n = 10). Fifty rats from the stepwise experimental group received initial advancement of 2 mm and another 1.5 mm of advancement on day 30 by the addition of veeners. On days 3, 7, 14, 21, 30, 33, 37, 44, 51, and 60, the rats were killed. One hour before that, the rats were injected with bromodeoxyuridine (BrdU) intravenously. We cut 7-μm tissue sections through the glenoid fossa sagittally and stained them with anti-BrdU antibody to evaluate the number of replicating mesenchymal cells. During the first advancement, the number of replicating cells in the posterior region of the glenoid fossa showed a significant increase compared with natural growth, but a significant decrease compared with 1-step advancement. On the second advancement, however, an increase in the number of replicating cells was observed on day 37 with a subsequent and significant increase in bone formation on day 44. Mandibular advancement conducted in a stepwise fashion increases the number of replicating mesenchymal cells in the glenoid fossa. However, a minimum threshold of strain must first be exceeded before these mesenchymal cells can differentiate to ultimately form new bone.
Persistent Identifierhttp://hdl.handle.net/10722/66522
ISSN
2015 Impact Factor: 1.69
2015 SCImago Journal Rankings: 1.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorWong, Len_HK
dc.contributor.authorHägg, Uen_HK
dc.date.accessioned2010-09-06T05:47:04Z-
dc.date.available2010-09-06T05:47:04Z-
dc.date.issued2003en_HK
dc.identifier.citationAmerican Journal Of Orthodontics And Dentofacial Orthopedics, 2003, v. 123 n. 5, p. 521-526en_HK
dc.identifier.issn0889-5406en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66522-
dc.description.abstractThe purposes of this study were to quantify the number of replicating mesenchymal cells and to correlate it with the amount of new bone formed in the glenoid fossa during stepwise advancement. We randomly divided 250 female Sprague-Dawley rats, 35 days old, into 10 control groups (n = 5) and 20 experimental groups (n = 10). Fifty rats from the stepwise experimental group received initial advancement of 2 mm and another 1.5 mm of advancement on day 30 by the addition of veeners. On days 3, 7, 14, 21, 30, 33, 37, 44, 51, and 60, the rats were killed. One hour before that, the rats were injected with bromodeoxyuridine (BrdU) intravenously. We cut 7-μm tissue sections through the glenoid fossa sagittally and stained them with anti-BrdU antibody to evaluate the number of replicating mesenchymal cells. During the first advancement, the number of replicating cells in the posterior region of the glenoid fossa showed a significant increase compared with natural growth, but a significant decrease compared with 1-step advancement. On the second advancement, however, an increase in the number of replicating cells was observed on day 37 with a subsequent and significant increase in bone formation on day 44. Mandibular advancement conducted in a stepwise fashion increases the number of replicating mesenchymal cells in the glenoid fossa. However, a minimum threshold of strain must first be exceeded before these mesenchymal cells can differentiate to ultimately form new bone.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajodoen_HK
dc.relation.ispartofAmerican Journal of Orthodontics and Dentofacial Orthopedicsen_HK
dc.rightsAmerican Journal of Orthodontics and Dentofacial Orthopedics. Copyright © Mosby, Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Differentiationen_HK
dc.subject.meshCell Divisionen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMandibular Advancement - instrumentation - methodsen_HK
dc.subject.meshMesoderm - cytologyen_HK
dc.subject.meshOrthodontic Appliances, Functionalen_HK
dc.subject.meshOsteoblasts - cytologyen_HK
dc.subject.meshOsteogenesis - physiologyen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStem Cells - cytologyen_HK
dc.subject.meshTemporal Bone - cytologyen_HK
dc.subject.meshTemporomandibular Joint - cytologyen_HK
dc.titleCorrelation of replicating cells and osteogenesis in the glenoid fossa during stepwise advancementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-5406&volume=123 No5&spage=521&epage=526&date=2003&atitle=Correlation+of+replicating+cells+and+osteogenesis+in+the+glenoid+fossa+during+stepwise+advancementen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0889-5406(02)57033-5en_HK
dc.identifier.pmid12750670-
dc.identifier.scopuseid_2-s2.0-0037607316en_HK
dc.identifier.hkuros95051en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037607316&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume123en_HK
dc.identifier.issue5en_HK
dc.identifier.spage521en_HK
dc.identifier.epage526en_HK
dc.identifier.isiWOS:000183085000007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridWong, L=7402092139en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK

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