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Article: The correlation of replicating cells and osteogenesis in the condyle during stepwise advancement

TitleThe correlation of replicating cells and osteogenesis in the condyle during stepwise advancement
Authors
KeywordsBone formation
Condyle
Osteoprogenitor cells
Stepwise advancement
Issue Date2003
PublisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/
Citation
Angle Orthodontist, 2003, v. 73 n. 4, p. 457-465 How to Cite?
AbstractThe aim of this study was to quantify the number of replicating mesenchymal cells and to correlate it to the amount of bone formation in the condyle during stepwise advancement of the mandible. Two hundred and fifty female Spraque-Dawley rats, 35 days old, were randomly divided into 10 control groups (n = 5) and 20 experimental groups (n = 10). Fifty rats from the stepwise experimental group relieved a two-mm advancement initially and veneers were added on day 30 with another 1.5 mm advancement. The rats were sacrificed after 3, 7, 14, 21, 30, 33, 37, 44, 51, and 60 days. One hour before death, all rats were injected with bromodeoxyuridine (BrdU) intravenously. Tissue sections of seven μm were cut through the condyle in the sagittal plane and stained with anti-BrdU antibody to evaluate the number of replicating mesenchymal cells. Haematoxylin stain was applied to observe cellular response. The results indicated that during the first advancement, replicating mesenchymal cells in the posterior region of the condyle showed the highest increase on days 7 and 14 when compared with the control. Such an increase preceded the highest level of bone formation between days 30 and 37 of advancement. In response to the second advancement, another increase of replicating cells was evident on day 44, along with a significant increase in bone formation observed on day 60. We concluded that forward positioning of mandible in a stepwise manner delivers a mechanical strain that solicits an increase in the number of replicating mesenchymal cells in the condyle. The increase in the population size of the osteoprogenitor cells subsequently leads to more bone formation.
Persistent Identifierhttp://hdl.handle.net/10722/66500
ISSN
2015 Impact Factor: 1.579
2015 SCImago Journal Rankings: 1.254
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRabie, ABMen_HK
dc.contributor.authorTsai, MJMen_HK
dc.contributor.authorHägg, Uen_HK
dc.contributor.authorDu, Xen_HK
dc.contributor.authorChou, BWen_HK
dc.date.accessioned2010-09-06T05:46:52Z-
dc.date.available2010-09-06T05:46:52Z-
dc.date.issued2003en_HK
dc.identifier.citationAngle Orthodontist, 2003, v. 73 n. 4, p. 457-465en_HK
dc.identifier.issn0003-3219en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66500-
dc.description.abstractThe aim of this study was to quantify the number of replicating mesenchymal cells and to correlate it to the amount of bone formation in the condyle during stepwise advancement of the mandible. Two hundred and fifty female Spraque-Dawley rats, 35 days old, were randomly divided into 10 control groups (n = 5) and 20 experimental groups (n = 10). Fifty rats from the stepwise experimental group relieved a two-mm advancement initially and veneers were added on day 30 with another 1.5 mm advancement. The rats were sacrificed after 3, 7, 14, 21, 30, 33, 37, 44, 51, and 60 days. One hour before death, all rats were injected with bromodeoxyuridine (BrdU) intravenously. Tissue sections of seven μm were cut through the condyle in the sagittal plane and stained with anti-BrdU antibody to evaluate the number of replicating mesenchymal cells. Haematoxylin stain was applied to observe cellular response. The results indicated that during the first advancement, replicating mesenchymal cells in the posterior region of the condyle showed the highest increase on days 7 and 14 when compared with the control. Such an increase preceded the highest level of bone formation between days 30 and 37 of advancement. In response to the second advancement, another increase of replicating cells was evident on day 44, along with a significant increase in bone formation observed on day 60. We concluded that forward positioning of mandible in a stepwise manner delivers a mechanical strain that solicits an increase in the number of replicating mesenchymal cells in the condyle. The increase in the population size of the osteoprogenitor cells subsequently leads to more bone formation.en_HK
dc.languageengen_HK
dc.publisherE H Angle Education and Research Foundation, Inc. The Journal's web site is located at http://www.angle.org/en_HK
dc.relation.ispartofAngle Orthodontisten_HK
dc.subjectBone formationen_HK
dc.subjectCondyleen_HK
dc.subjectOsteoprogenitor cellsen_HK
dc.subjectStepwise advancementen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAntimetabolites - diagnostic useen_HK
dc.subject.meshBromodeoxyuridine - diagnostic useen_HK
dc.subject.meshCell Counten_HK
dc.subject.meshCell Division - physiologyen_HK
dc.subject.meshColoring Agents - diagnostic useen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshImage Processing, Computer-Assisteden_HK
dc.subject.meshMandibular Advancement - methodsen_HK
dc.subject.meshMandibular Condyle - cytology - physiologyen_HK
dc.subject.meshMatched-Pair Analysisen_HK
dc.subject.meshMesoderm - cytology - physiologyen_HK
dc.subject.meshOsteogenesis - physiologyen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshStress, Mechanicalen_HK
dc.titleThe correlation of replicating cells and osteogenesis in the condyle during stepwise advancementen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-3219&volume=73&issue=4&spage=457&epage=465&date=2003&atitle=The+correlation+of+replicating+cells+and+osteogenesis+in+the+condyle+during+stepwise+advancementen_HK
dc.identifier.emailRabie, ABM: rabie@hku.hken_HK
dc.identifier.emailHägg, U: euohagg@hkusua.hku.hken_HK
dc.identifier.authorityRabie, ABM=rp00029en_HK
dc.identifier.authorityHägg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid12940568-
dc.identifier.scopuseid_2-s2.0-0242304956en_HK
dc.identifier.hkuros80080en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0242304956&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume73en_HK
dc.identifier.issue4en_HK
dc.identifier.spage457en_HK
dc.identifier.epage465en_HK
dc.identifier.isiWOS:000184585400020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridRabie, ABM=7007172734en_HK
dc.identifier.scopusauthoridTsai, MJM=36752458000en_HK
dc.identifier.scopusauthoridHägg, U=7006790279en_HK
dc.identifier.scopusauthoridDu, X=7402551294en_HK
dc.identifier.scopusauthoridChou, BW=7005140370en_HK

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