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Article: Effects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells

TitleEffects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cells
Authors
Issue Date2004
PublisherChinese Medical Association (中華醫學會). The Journal's web site is located at http://zhkqyx.periodicals.net.cn/default.html
Citation
Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal Of Stomatology, 2004, v. 39 n. 3, p. 197-200 How to Cite?
AbstractOBJECTIVE: To investigate the influence of baicalin on the IL-1beta induced pro-MMP-1 in HGF and the effects of baicalin on MMP-3 expression in periodontal ligament cells (PDLCs). METHODS: The amount of secreted pro-MMP-1 and MMP-3 expression was detected by ELISA and cell immunochemistry. RESULTS: (1) The amount of secreted pro-MMP-1 (3.333 +/- 0.123) microg/L increased significantly following 1 microg/L of IL-1beta, compared with control group (1.960 +/- 0.180) microg/L. Addition of baicalin to cell culture medium for 1 hour following IL-1beta decreased pro-MMP-1 secretion in a dose-dependent manner in the range of 10 approximately 1,000 microg/L. (2) 1 microg/L IL-1beta could significantly stimulate the synthesis and secretion of MMP-3 in PDLCs. (3) The baicalin could not interfere the synthesis of MMP-3, but could inhibit the release of MMP-3 from PDLCs. CONCLUSIONS: Baicalin could inhibit the secretion of pro-MMP-1 and MMP-3 expression in IL-1beta induced HGF and PDLCs, which suggests that baicalin may play an important role in preventing and treating periodontal disease.
Persistent Identifierhttp://hdl.handle.net/10722/66453
ISSN
2015 SCImago Journal Rankings: 0.121

 

DC FieldValueLanguage
dc.contributor.authorLi, CZen_HK
dc.contributor.authorCao, ZGen_HK
dc.contributor.authorYang, Ren_HK
dc.contributor.authorShang, ZHen_HK
dc.contributor.authorJin, LJen_HK
dc.contributor.authorCobert, EFen_HK
dc.date.accessioned2010-09-06T05:46:29Z-
dc.date.available2010-09-06T05:46:29Z-
dc.date.issued2004en_HK
dc.identifier.citationZhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal Of Stomatology, 2004, v. 39 n. 3, p. 197-200en_HK
dc.identifier.issn1002-0098en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66453-
dc.description.abstractOBJECTIVE: To investigate the influence of baicalin on the IL-1beta induced pro-MMP-1 in HGF and the effects of baicalin on MMP-3 expression in periodontal ligament cells (PDLCs). METHODS: The amount of secreted pro-MMP-1 and MMP-3 expression was detected by ELISA and cell immunochemistry. RESULTS: (1) The amount of secreted pro-MMP-1 (3.333 +/- 0.123) microg/L increased significantly following 1 microg/L of IL-1beta, compared with control group (1.960 +/- 0.180) microg/L. Addition of baicalin to cell culture medium for 1 hour following IL-1beta decreased pro-MMP-1 secretion in a dose-dependent manner in the range of 10 approximately 1,000 microg/L. (2) 1 microg/L IL-1beta could significantly stimulate the synthesis and secretion of MMP-3 in PDLCs. (3) The baicalin could not interfere the synthesis of MMP-3, but could inhibit the release of MMP-3 from PDLCs. CONCLUSIONS: Baicalin could inhibit the secretion of pro-MMP-1 and MMP-3 expression in IL-1beta induced HGF and PDLCs, which suggests that baicalin may play an important role in preventing and treating periodontal disease.en_HK
dc.languageengen_HK
dc.publisherChinese Medical Association (中華醫學會). The Journal's web site is located at http://zhkqyx.periodicals.net.cn/default.htmlzh_HK
dc.relation.ispartofZhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatologyen_HK
dc.subject.meshCollagenases - biosynthesis - geneticsen_HK
dc.subject.meshEnzyme Precursors - biosynthesis - geneticsen_HK
dc.subject.meshFibroblasts - enzymology - pathologyen_HK
dc.subject.meshFlavonoids - pharmacologyen_HK
dc.subject.meshGingiva - enzymology - pathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterleukin-1 - pharmacologyen_HK
dc.subject.meshInterleukin-1betaen_HK
dc.subject.meshMatrix Metalloproteinase 1en_HK
dc.subject.meshMetalloendopeptidases - biosynthesis - geneticsen_HK
dc.subject.meshPeptide Fragments - pharmacologyen_HK
dc.subject.meshPeriodontal Ligament - enzymology - pathologyen_HK
dc.subject.meshPeriodontitis - enzymology - pathologyen_HK
dc.subject.meshScutellaria - chemistryen_HK
dc.titleEffects of baicalin on the expression of pro-MMP-1 and MMP-3 in human gingival fibroblasts and periodontal ligament cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailJin, LJ:ljjin@hkucc.hku.hken_HK
dc.identifier.authorityJin, LJ=rp00028en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15196384-
dc.identifier.scopuseid_2-s2.0-21644469282en_HK
dc.identifier.hkuros88962en_HK
dc.identifier.volume39en_HK
dc.identifier.issue3en_HK
dc.identifier.spage197en_HK
dc.identifier.epage200en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridLi, CZ=15728225200en_HK
dc.identifier.scopusauthoridCao, ZG=7402432479en_HK
dc.identifier.scopusauthoridYang, R=23037764400en_HK
dc.identifier.scopusauthoridShang, ZH=8424996900en_HK
dc.identifier.scopusauthoridJin, LJ=7403328850en_HK
dc.identifier.scopusauthoridCobert, EF=8424997100en_HK

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