File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Forward deviation of the mandibular condyle enhances endochondral ossification of condylar cartilage indicated by increased expression of type X collagen

TitleForward deviation of the mandibular condyle enhances endochondral ossification of condylar cartilage indicated by increased expression of type X collagen
Authors
KeywordsCondylar adaptation
Endochondral ossification
Type X collagen
Issue Date2006
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbio
Citation
Archives Of Oral Biology, 2006, v. 51 n. 4, p. 315-324 How to Cite?
AbstractObjective: Using type X collagen as a marker, this research was designed to examine the alteration of condylar growth in response to mandibular condylar forward positioning. Methods: One hundred female Sprague-Dawley rats with 5 weeks of age were randomly divided into five experimental and five control groups. In the experimental groups, bite jumping appliances created forward positioning of the condyle. The experimental rats, together with the age-matched controls, were sacrificed on days 3, 7, 14, 21 and 30, respectively. Tissue sections were cut in the sagittal plane through the mandibular condyle and were processed for in situ hybridization and immunostaining of type X collagen and then for quantitative imaging analyses. Results: (1) Both type X collagen mRNA in situ hybridization signals and type X collagen immunostaining were localized within the hypertrophic zone of the condylar cartilage. (2) With condylar forward positioning, the level of type X collagen mRNA signals (8541 ± 74 μm 2 at peak) was 300% higher than that in the controls (2117 ± 78 μm 2 at peak); type X collagen immunostaining in condylar advancing groups (54864 ± 134 μm 2 at peak) was 254% more than that in the controls (15470 ± 121 μm 2 at peak). (3) The amount of type X collagen mRNA signals and immunostaining in experimental and control groups reached the highest levels at day 14 and day 21, respectively, indicating that an increase in endochondral ossification occurred 21 days after condylar forward deviation. Conclusion: Condylar forward repositioning provokes an enhanced maturation of condylar chondrocytes resulting in increased synthesis of type X collagen, a extracellular protein that attributes to endochondral ossification. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/66433
ISSN
2015 Impact Factor: 1.733
2015 SCImago Journal Rankings: 0.713
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShen, Gen_HK
dc.contributor.authorRabie, ABen_HK
dc.contributor.authorZhao, ZHen_HK
dc.contributor.authorKaluarachchi, Ken_HK
dc.date.accessioned2010-09-06T05:46:19Z-
dc.date.available2010-09-06T05:46:19Z-
dc.date.issued2006en_HK
dc.identifier.citationArchives Of Oral Biology, 2006, v. 51 n. 4, p. 315-324en_HK
dc.identifier.issn0003-9969en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66433-
dc.description.abstractObjective: Using type X collagen as a marker, this research was designed to examine the alteration of condylar growth in response to mandibular condylar forward positioning. Methods: One hundred female Sprague-Dawley rats with 5 weeks of age were randomly divided into five experimental and five control groups. In the experimental groups, bite jumping appliances created forward positioning of the condyle. The experimental rats, together with the age-matched controls, were sacrificed on days 3, 7, 14, 21 and 30, respectively. Tissue sections were cut in the sagittal plane through the mandibular condyle and were processed for in situ hybridization and immunostaining of type X collagen and then for quantitative imaging analyses. Results: (1) Both type X collagen mRNA in situ hybridization signals and type X collagen immunostaining were localized within the hypertrophic zone of the condylar cartilage. (2) With condylar forward positioning, the level of type X collagen mRNA signals (8541 ± 74 μm 2 at peak) was 300% higher than that in the controls (2117 ± 78 μm 2 at peak); type X collagen immunostaining in condylar advancing groups (54864 ± 134 μm 2 at peak) was 254% more than that in the controls (15470 ± 121 μm 2 at peak). (3) The amount of type X collagen mRNA signals and immunostaining in experimental and control groups reached the highest levels at day 14 and day 21, respectively, indicating that an increase in endochondral ossification occurred 21 days after condylar forward deviation. Conclusion: Condylar forward repositioning provokes an enhanced maturation of condylar chondrocytes resulting in increased synthesis of type X collagen, a extracellular protein that attributes to endochondral ossification. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/archoralbioen_HK
dc.relation.ispartofArchives of Oral Biologyen_HK
dc.subjectCondylar adaptationen_HK
dc.subjectEndochondral ossificationen_HK
dc.subjectType X collagenen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBiological Markers - analysisen_HK
dc.subject.meshCartilage - chemistry - pathology - physiopathologyen_HK
dc.subject.meshChondrocytes - chemistryen_HK
dc.subject.meshCollagen Type X - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHypertrophyen_HK
dc.subject.meshImmunoenzyme Techniques - methodsen_HK
dc.subject.meshIn Situ Hybridization - methodsen_HK
dc.subject.meshMalocclusion - pathology - physiopathologyen_HK
dc.subject.meshMandibular Condyle - chemistry - growth & developmenten_HK
dc.subject.meshOssification, Heterotopic - physiopathologyen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRandom Allocationen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.titleForward deviation of the mandibular condyle enhances endochondral ossification of condylar cartilage indicated by increased expression of type X collagenen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0003-9969&volume=51&spage=315&epage=324&date=2006&atitle=Forward+deviation+of+the+mandibular+condyle+enhances+endochondral+ossification+of+condylar+cartilage+indicated+by+increased+expression+of+type+X+collagenen_HK
dc.identifier.emailRabie, AB: rabie@hku.hken_HK
dc.identifier.authorityRabie, AB=rp00029en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.archoralbio.2005.08.004en_HK
dc.identifier.pmid16199001-
dc.identifier.scopuseid_2-s2.0-33644836439en_HK
dc.identifier.hkuros124245en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644836439&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue4en_HK
dc.identifier.spage315en_HK
dc.identifier.epage324en_HK
dc.identifier.isiWOS:000236571200006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridShen, G=7401966958en_HK
dc.identifier.scopusauthoridRabie, AB=7007172734en_HK
dc.identifier.scopusauthoridZhao, ZH=14066852000en_HK
dc.identifier.scopusauthoridKaluarachchi, K=36905056500en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats