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Article: Genotypic variation of Candida albicans during orthodontic therapy

TitleGenotypic variation of Candida albicans during orthodontic therapy
Authors
Issue Date2008
PublisherFrontiers in Bioscience.
Citation
Frontiers In Bioscience, 2008, v. 13 n. 10, p. 3814-3824 How to Cite?
AbstractCandida is a common oral, opportunistic pathogen. The aim of this longitudinal study was to analyze the genotypes of sequential isolates of Candida albicans in a cohort of healthy consistent candidal carriers ('carriers') during fixed orthodontic appliance therapy. 11 of 97 subjects were 'carriers'. Candida isolates from baseline samples (T0) and sequential visits after insertion (T1 to T10) were speciated and RAPD fingerprint patterns of 101 sequential Candida albicans isolates were analyzed with PCR and gel electrophoresis. A similarity coefficient (SAB) for each pair of strains was calculated and clusters of similar strains grouped using Dendrogram analysis of the RAPD gel profiles. The composite dendrogram of all isolates indicated that the Candida populations in this cohort are genotypically dissimilar although collected from the same geographic locale and, from a similar healthy, age group. Genotypes of a majority of the cohort (6 of 11 consistent carriers) show minor evolutionary variations in profile and genotypic 'shuffling', implying this may be a survival mechanism of this common, human, opportunist pathogen residing in a hostile oral environment.
Persistent Identifierhttp://hdl.handle.net/10722/66414
ISSN
2015 Impact Factor: 2.484
2015 SCImago Journal Rankings: 1.583
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, Wen_HK
dc.contributor.authorLow, BKMen_HK
dc.contributor.authorSamaranayake, LPen_HK
dc.contributor.authorHagg, Uen_HK
dc.date.accessioned2010-09-06T05:46:09Z-
dc.date.available2010-09-06T05:46:09Z-
dc.date.issued2008en_HK
dc.identifier.citationFrontiers In Bioscience, 2008, v. 13 n. 10, p. 3814-3824en_HK
dc.identifier.issn1093-9946en_HK
dc.identifier.urihttp://hdl.handle.net/10722/66414-
dc.description.abstractCandida is a common oral, opportunistic pathogen. The aim of this longitudinal study was to analyze the genotypes of sequential isolates of Candida albicans in a cohort of healthy consistent candidal carriers ('carriers') during fixed orthodontic appliance therapy. 11 of 97 subjects were 'carriers'. Candida isolates from baseline samples (T0) and sequential visits after insertion (T1 to T10) were speciated and RAPD fingerprint patterns of 101 sequential Candida albicans isolates were analyzed with PCR and gel electrophoresis. A similarity coefficient (SAB) for each pair of strains was calculated and clusters of similar strains grouped using Dendrogram analysis of the RAPD gel profiles. The composite dendrogram of all isolates indicated that the Candida populations in this cohort are genotypically dissimilar although collected from the same geographic locale and, from a similar healthy, age group. Genotypes of a majority of the cohort (6 of 11 consistent carriers) show minor evolutionary variations in profile and genotypic 'shuffling', implying this may be a survival mechanism of this common, human, opportunist pathogen residing in a hostile oral environment.en_HK
dc.languageengen_HK
dc.publisherFrontiers in Bioscience.en_HK
dc.relation.ispartofFrontiers in Bioscienceen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshCandida albicans - genetics - growth & development - isolation & purification - pathogenicityen_HK
dc.subject.meshChilden_HK
dc.subject.meshChinaen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshDNA Primersen_HK
dc.subject.meshDNA, Fungal - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenetic Variationen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshOpportunistic Infections - microbiologyen_HK
dc.subject.meshOrthodonticsen_HK
dc.subject.meshRandom Amplified Polymorphic DNA Techniqueen_HK
dc.titleGenotypic variation of Candida albicans during orthodontic therapyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1093-9946&volume=13&spage=3814&epage=3824&date=2008&atitle=Genotypic+variation+of+Candida+albicans+during+orthodontic+therapyen_HK
dc.identifier.emailSamaranayake, LP:lakshman@hku.hken_HK
dc.identifier.emailHagg, U:euohagg@hkusua.hku.hken_HK
dc.identifier.authoritySamaranayake, LP=rp00023en_HK
dc.identifier.authorityHagg, U=rp00020en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.2741/2970en_HK
dc.identifier.pmid18508476-
dc.identifier.scopuseid_2-s2.0-42649086760en_HK
dc.identifier.hkuros139820en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42649086760&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume13en_HK
dc.identifier.issue10en_HK
dc.identifier.spage3814en_HK
dc.identifier.epage3824en_HK
dc.identifier.isiWOS:000255885000051-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLee, W=24071228900en_HK
dc.identifier.scopusauthoridLow, BKM=24166942600en_HK
dc.identifier.scopusauthoridSamaranayake, LP=7102761002en_HK
dc.identifier.scopusauthoridHagg, U=7006790279en_HK

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